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12  structures 1706  species 2  interactions 3673  sequences 11  architectures

Clan: Peptidase_ML (CL0095)

Summary

Peptidase Clan ML Add an annotation

This clan contains HybD-like domains. HybD is a nickel binding endopeptidase. Structural and sequences analyses have highlighted the presence of two highly conserved motifs that are shared with germination proteases and HybD [1]. Members of this clan adopt an alpha/beta fold, comprised of a central beta sheet, surrounded by alpha helices.

This clan contains 3 families and the total number of domains in the clan is 3673. The clan was built by RD Finn.

Literature references

  1. Pei J, Grishin NV; , Protein Sci 2003;12:1131-1135.: Peptidase family U34 belongs to the superfamily of N-terminal nucleophile hydrolases. PUBMED:12717035 EPMC:12717035

Members

This clan contains the following 3 member families:

DUF1256 HycI Peptidase_A25

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HycI (PF01750) 2632 (71.7%) View
Peptidase_A25 (PF03418) 602 (16.4%) View
DUF1256 (PF06866) 439 (12.0%) View
Total: 3 Total: 3673 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
Peptidase_A25 Peptidase_A25
HycI HycI

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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