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1518  structures 7761  species 5  interactions 108830  sequences 588  architectures

Clan: ALDH-like (CL0099)


ALDH-like superfamily Add an annotation

The aldehyde dehydrogenases (ALDHs) are a superfamily of multimeric enzymes which catalyse the oxidation of a broad range of aldehydes into their corresponding carboxylic acids with the reduction of their cofactor, NAD(P) into NAD(P)H. The way that the NAD is bound is distinct from other NAD(P)-dependent oxidoreductases. The domain represented by this clan consists of two similar subdomains.

This clan contains 4 families and the total number of domains in the clan is 108830. The clan was built by RD Finn.


This clan contains the following 4 member families:

Aldedh DUF1487 Histidinol_dh LuxC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Aldedh (PF00171) 99197 (91.1%) View
Histidinol_dh (PF00815) 8423 (7.7%) View
LuxC (PF05893) 1087 (1.0%) View
DUF1487 (PF07368) 123 (0.1%) View
Total: 4 Total: 108830 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Aldedh Aldedh
Histidinol_dh Histidinol_dh
Pro_dh Aldedh
Pro_dh-DNA_bdg Aldedh


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...