Sequence alignment for CL0100

PF00229

TNF18_MOUSE/61-166-------------------------SKWHMTSP..KPHCVN..TTSDGK..LKILQSGTYLIYGQVIPV......DKKYI
TN13B_MOUSE/190-308-------------------------VPW.......LLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYT...........
TNF15_HUMAN/117-251-------------------------LHWEHELG..LAFTKNRMNYTNKF..LLIPESGDYFIYSQVTFR......GMTSE
TNF10_HUMAN/152-280-------------------------NSWESSRS..GHSFLSNLHLRNGE..LVIHEKGFYYIYSQTYFR...........
Q90WT9_CHICK/158-285-------------------------TRWEDST...IHSHLQNITYRDGR..LRVNQAGKYYVYSQIYFRYSRDGAGARVS
Q9DEP9_ONCMY/121-255-------------------------VQWRKDDG..QAFSQGGFKLQGNQ..ILIPHTGLFFVYSQASFR.......VKCN
TNFB_MOUSE/74-202-------------------------LLWRASTD..RAFLRHGFSLSNNS..LLIPTSGLYFVYSQVVFS......GESCS
TNFL8_HUMAN/113-230-------------------------LSWNKDGI......LHGVRYQDGN..LVIQFPGLYFIICQLQFL.......VQCP
TNF10_MOUSE/156-290-------------------------ESWESSRK..GHSFLNHVLFRNGE..LVIEQEGLYYIYSQTYFR......FQEAE
TNFA_SAISC/102-233-------------------------LQWLNRRA..NALLANGVELRDNQ..LVVPSDGLYLVYSQVLFK......GQGCP
TNFL4_RAT/77-185-------------------------IGTSKNEY.......ETMEVQNNS..VIINCDGLYLIHLKGSFF...........
Q69HR0_CIOIN/178-304-------------------------TDWAPPD...SHFKGFGTRHLNNDGYFTVPVAGVYFVYSQVVFN.....V.....
TNFA_MACEU/102-233-------------------------LQWLKRRA..NVLLSNGMDLVDNQ..LVVPSTGLYLVYSQLLFK......GEDCA
TNFL9_MOUSE/164-302-------------------------LNWHSQDGAGSSYLSQGLRYEEDKKELVVDSPGLYYVFLELKLSP....TFTNTG
Q8JG37_ICTPU/95-230-------------------------MQWFDNA...DQSFSSGLKLEDNE..IKILRDGLYFVYSQASYR.......LLCK
TNFB_MACEU/74-201-------------------------IHWRANTD..HAFLRHGFSLSNNS..LLVPTSGLYFVYSQVVFS......GASCS
Q800J1_CHICK/114-232-------------------------LSLTDNGV......CDNIQCKSEE..LVIRKQGLYLIYCHLNFH......FANCS
CD70_MOUSE/75-193-------------------------LRWGAGPA.LGRSFTHGPELEEGH..LRIHQDGLYRLHIQVTLA........NCS
CD70_HUMAN/73-191-------------------------LYWQGGPA.LGRSFLHGPELDKGQ..LRIHRDGIYMVHIQVTLA........ICS
Q6T9C7_DANRE/102-234-------------------------LDWRDDQD..QAFSSGGLKLVNRE..IIIPDDGIYFVYSQVSLH.......ISCT
TNFL8_MOUSE/118-235-------------------------LSWNEDGT......IHGLIYQDGN..LIVQFPGLYFIVCQLQFL.......VQCS
TNFC_MACEU/101-249-------------------------LRWVSGYE..EAFLKSGTQFLGDEGLLALPQDGIYFLYCHIGYR......GRAPS
Q6U817_LATJA/102-241-------------------------LEWKNGQG..QAFAQGGFRLVNNQ..IVIPQTGLYFVYCQASFR.......VSCS
EDA_MOUSE/272-385-------------------------NDWSR.....ITMNPKVFKLHPRSGELEVLVDGTYFIYSQVEV............
Q7T1F2_CHICK/156-290-------------------------HSWESSRR..GHSFLYNVELWNGE..LVVPQTGFYYIYSQTYFR......FRENE
Q9IB41_PAROL/83-225-------------------------LVWKNDEG..LAFTQGGFELVDNH..IIIPRSGLYSVYSQASFR.......VSCS
TNFC_HUMAN/102-243-------------------------LGWETTKE..QAFLTSGTQFSDAE.GLALPQDGLYYLYCLVGYR......GRAPP
B2RR33_MOUSE/118-252-------------------------LHWEHDLG..MAFTKNGMKYINKS..LVIPESGDYFIYSQITFR......GTTSV
CD40L_MOUSE/137-260-------------------------LQWAKKGY..YTMKSNLVMLENGK.QLTVKREGLYYVYTQVTFC......SNREP
TNFL4_RABIT/81-186-------------------------LPLQKRD........GTMEVQNNS..VVIQCDGFYLLSLKGYFS...........
TNF12_HUMAN/131-248-------------------------SGWEEARI..NSSSPLRYNRQIGE..FIVTRAGLYYLYCQVHFD.......EGKA
TNFB_HUMAN/77-205-------------------------LLWRANTD..RAFLQDGFSLSNNS..LLVPTSGIYFVYSQVVFS......GKAYS
TNFL4_HUMAN/77-182-------------------------LTSQKED........EIMKVQNNS..VIINCDGFYLISLKGYFS...........
Q6DHG9_DANRE/158-298-------------------------QSWESEK...GLAFLQNVELSDGE..LVVPQAGLYYIYSQTYFR......HTLIE
TNFC_MOUSE/168-305-------------------------LSWEASQE..EAFLRSGAQFSPTH.GLALPQDGVYYLYCHVGYR......GRTPP
Q7ZYX9_DANRE/187-315-------------------------HTWANKS...FGAHLYNMTLTNGR..LRVPQDGRYYLYSQVYFR......YPSPS
TNFA_CAPHI/103-234-------------------------LRWGDSYA..NALKANGVELKDNQ..LVVPTDGLYLIYSQVLFR......GHGCP
TNFL9_HUMAN/107-240-------------------------LSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRV..VAGEGSG
TNF11_HUMAN/185-313-------------------------SSWYHDR...GWAKISNMTFSNGK..LIVNQDGFYYLYANICFR......HHETS
CD40L_FELCA/137-260-------------------------LQWAPKGY..YTISSNLVTLENGK.QLAVKRQGLYYIYAQVTFC......SNREA
TNF14_MOUSE/110-239-------------------------LLWETRL...GLAFLRGLTYHDGA..LVTMEPGYYYVYSKVQLS......GVGCP
TNF13_HUMAN/136-250-------------------------VMW.......QPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQ........DVT
Q8IGD3_DROME/300-409-------------------------NE........RNSYQGHFQTRDGV..LTVTNTGLYYVYAQICYN...........
CD40L_CHICK/152-272-------------------------LKWMTTS...YAPTSSLISYHEGK..LKVEKAGLYYIYSQVSFC.....TKAAAS
TNFL6_RAT/157-278-------------------------LEWEDTY...GTALISGVKYKKGG..LVINEAGLYFVYSKVYFR......GQSCN
Q8AW02_CYPCA/97-231-------------------------LDWKQNQD..QAFVSGGLELVDRE..IIIPNDGIYFVYSQVSFH.......ISCK
TNFA_LAMGL/102-233-------------------------LQWEKRFA..NTLLANGVKLEDNQ..LVVPTDGLYLIYSQVLFS......GQRCP
TNFA_RABIT/105-235-------------------------LQWLSQRA..NALLANGMKLTDNQ..LVVPADGLYLIYSQVLFS......GQGCR
Q6DI63_MOUSE/142-243-------------------------NSVVTNPQ.......GHYNPSTGK..FTCEVPGLYYFVYYTSHT......ANLC.
Q8AWC9_CYPCA/103-237-------------------------LDWKKNQD..QAFTSGGLKLVERE..IIIPTDGIYFVYSQVSFH.......INCK
TNFA_TRIVU/102-233-------------------------LLWVGDVA..NTLLMNGMELVDNQ..LVLPSTGLYLVYSQLLYK......GSQCG
Q7T2Q3_CYPCA/93-227-------------------------IDWKQNQD..GAFVSGGLKLVDRE..IIIPNDGIYFIYSQVSFH.......ISCK

PF00386

MMRN2_HUMAN/827-946AFYASFSEGTAAL.Q.........TVKFNT....TYINIGSSYFPEHGY--FRAPERGVYLFAVSVE..-----------
C1QT8_HUMAN/118-246AFSVGRREGLHSS.DHFQ......AVPFDT....ELVNLDGAFDLAAGR--FLCTVPGVYFLSLNVH..-----------
C1QT6_HUMAN/126-254AFSVGRKTALHSG.EDFQ......TLLFER....VFVNLDGCFDMATGQ--FAAPLRGIYFFSLNVH..-----------
Q7T129_DANRE/91-222AFSASLLSSHNIR.YIGPYA.EDTMIVYGK....IFTNIGNAYNTTTGI--FTAPVKGVYFFNLVLF..-----------
Q7T137_DANRE/76-204AFSAGLMASGQGQ.T.GPIG.SEKTLVYKK....VFSNVGNAYDSNTGI--FTAPVKGVYYFRFYGH..-----------
MMRN2_MOUSE/821-940AFYAGSSEGATAL.Q.........MVKFNT....TSINVGSSYFPEHGY--FRAPKRGVYLFAVSIT..-----------
CAPR2_DANRE/786-911AFSAARTANFAPG.TLDQ......PIAFDL....LHTNLGDMFDTGSGR--FTCPATGAYVFIFHIL.K-----------
C1T9A_HUMAN/203-329AFTVGLTVLSKFP.SSDM......PIKFDK....ILYNEFNHYDTAAGK--FTCHIAGVYYFTYHIT..-----------
MMRN1_HUMAN/1102-1225AFFASHTYGMTIP.G.........PILFNN....LDVNYGASYTPRTGK--FRIPYLGVYVFKYTIESF-----------
Q70SH0_9EUPU/26-150AFTAVLDKNLVLENGD........TLIPNK....ILINYGGGYNDKTGI--FTAPKSGIYHLGVHAQ..-----------
C1QT4_MOUSE/30-155AFSAARTTPLEGT.SEM.......AVTFDK....VYVNIGGDFDAATGR--FRCRVPGAYFFSFTAG..-----------
C1QC_HUMAN/121-242VFTVTRQTHQPPAPNS........LIRFNA....VLTNPQGDYDTSTGK--FTCKVPGLYYFVYHAS..-----------
C1QT4_MOUSE/176-309AFSAARTRSLVGS.DAAPGP.RHRPLAFDT....ELVNIGGDFDAAAGV--FRCRLPGAYFFSFTLG..-----------
C1QA_HUMAN/116-241AFSAIRRNPPMGGN..........VVIFDT....VITNQEEPYQNHSGR--FVCTVPGYYYFTFQVLSQ-----------
C1QA_PIG/118-243AFSAVRQNPPTSGN..........VVIFDE....VITNQEGAYKSQLGQ--FICDVPGYYYFTFQVVSK-----------
Q7T126_DANRE/61-194AFSASLLTTFGPQ.SVGPFYNGLHTLIYKH....VFLNFGSNYDPNTGI--FTAPVKGVYVFTVFSKAF-----------
C1QL3_MOUSE/128-252AFYAGLKRQHEGYE..........VLKFDD....VVTNLGNHYDPTTGK--FTCSIPGIYFFTYHVLMR-----------
C1QA_MOUSE/116-241AFSAIRQNPMTLGN..........VVIFDK....VLTNQESPYQNHTGR--FICAVPGFYYFNFQVISK-----------
Q6LA35_LAMJA/119-237AFSAKVDAYKPAA.GS........PVTFNV....IITNPQ.PLQPRHGK--FTCAHPGVYYFTLYAH..-----------
Q6PP07_PIG/113-238AFSVGLETRVTVP...NM......PIRFTK....IFYNQQNHYDVTTGK--FHCNIPGLYYFSFHIT..-----------
Q6UQ16_MYTED/109-235AFSAELTHPIENI.AAEE......IAHFDK....VRVNSGHAYHADTGK--FVAPEEGFFYFSVTICTK-----------
CO8A2_MOUSE/572-696AFTAVLT..SPFP.ASGM......PVRFDR....TLYNGHSGYNPATGI--FTCPVGGVYYFAYHVH..-----------
D6R934_HUMAN/121-245AFSATRTINVPLRRDQ........TIRFDH....VITNMNNNYEPRSGK--FTCKVPGLYYFTYHAS..-----------
Q6DBS9_DANRE/118-238VFSYKKSQKLEKILQDK.......LVVFDV....PLISGIDGVLDGEGY--FDVTITGMYYISYQISFQ-----------
Q9PT14_ONCMY/45-176AFSASFMINDEHY.HLGPFG.ENTTVVYEK....VITNIGEAYNPDTGV--FTAPVRGAYYFTFTCNVG-----------
HP27_TAMSI/91-212AFAVKANELPPAPSQ.........PVIFKE....ALHDAQGHFDLATGV--FTCPVPGLYQFGFHIE..-----------
HP20_TAMSI/73-194AFTVKFSGRLPPPSE.........PVVFTE....VLYNTQRDLKESTGV--FNCVEPGNYHFSFDVE..-----------
Q6DJ45_XENTR/107-232AFSMGLSTKSSLP...NV......PIRFTK....VFYNEQRHYDDSTGK--FRCAIKGLYQFSYHLT..-----------
HP25_TAMSI/91-212AFAVKLSERPPEPFQ.........PIVFKE....ALYNQEGHFNMATGE--FSCVLPGVYNFGFDIR..-----------
Q6L7J6_CYPCA/48-176AFSAKLSESRTSPLVVGD......AVRFDK....IILNEQGDYNPETGR--FTCRVPGVYYFTVHAT..-----------
OTOL1_ONCKE/377-502AFSVGLFPSKSFP.PPGL......PVKFDK....ILYNEEEHWDPMLSK--FNCTHPGVYVFSYHIT..-----------
Q8JI26_SALFO/92-219IFSAALGGNG....HTGPID.HDTTLIYKE....VITNIGGAYNPSTGV--FAAPIAGVYYFSFFYHAG-----------
Q9GQV4_STRPU/36-175AFTVERTADMSDSTTSRD......IGAFNKNSQKIYLNIGEALDVVTGR--FKVPLEGVYYFYYSFSSE-----------
Q6QWE7_CHICK/112-237AFSVGLTERAPHP...NV......PIRFTK....IFYNEQNHYDSSTGK--FLCSIPGTYFFAYHLT..-----------
Q6PS61_CARAU/82-210AFSAGLLESGTG..HTGPFN.SVTTLVYKK....VFSNIGGAYDSKTGV--FTAPVKGAYYFKFYGHGH-----------
C1QC_MOUSE/122-243VFTVTRQTTQYPEANA........LVRFNS....VVTNPQGHYNPSTGK--FTCEVPGLYYFVYYTS..-----------
CO8A1_RABIT/617-741AFTAELT..APFP.PVGA......PIKFDR....LLYNGRQNYNPQTGI--FTCEVPGVYYFAYHVH..-----------
Q6GPX5_XENLA/123-244AFTVARLTQEHPLKNT........PILFTK....QITNDHQDYNVTSGK--FQCRIPGHYFFSFHSS..-----------
COAA1_BOVIN/547-671AFTVILS..KAYP.AIGT......PIPFDK....ILYNKQQHYDPRTGI--FTCKIPGIYYFSYHIH..-----------
Q7T128_DANRE/102-228AFSVSLASVVGPH.....SS..LHGLIYKH....IFLNSGDAYDSNTGI--FTAPIKGVYAFWLFSKAY-----------
C1QT5_MOUSE/105-232AFSAKRSESRVPP.PADT......PLPFDR....VLLNEQGHYDPTTGK--FTCQVPGVYYFAVHAT..-----------
C1QT2_HUMAN/151-275AFSVAVT..KSYP.RERL......PIKFDK....ILMNEGGHYNASSGK--FVCGVPGIYYFTYDIT..-----------
Q8R1P2_MOUSE/48-176AFSVGRKKALHSN.DYFQ......PVVFDT....EFVNLYKHFNMFTGK--FYCYVPGIYFFSLNVHTW-----------
C1QT3_MOUSE/119-242AFMASLATHFSNQ.NS........GIIFSS....VETNIGNFFDVMTGR--FGAPVSGVYFFTFSMM.K-----------
Q6NUY7_DANRE/772-890AFFASVNSILPATAK.........VVVFGQ....VLYNGQNHYNQTSGM--FLCQIPGVYEFEFSCI..-----------
C1QT7_MOUSE/149-273AFSVGIT..TSYP.EERL......PIIFNK....VLFNEGEHYNPATGK--FICAFPGIYYFSYDIT..-----------

PF00229

TNF18_MOUSE/61-166KD................NAPFVVQIYKKNDVL......---.QTLMN.....................DFQILPIGGVY
TN13B_MOUSE/190-308D................PIFAMGHVIQRKKVHVFGDELS---LVTLFRCIQNMPKTLPN............NSCYSAGIA
TNF15_HUMAN/117-251CSEIRQA......GRPNKPDSITVVITKVTDSY....PE---PTQLLMGTK.SVCEVGSN.........WFQPIYLGAMF
TNF10_HUMAN/152-280FQEEIKE......NTKND.KQMVQYIYKYTSY.....PD---PILLMKSAR.NSCWSKDAEY.......GLYSIYQGGIF
Q90WT9_CHICK/158-285...................VPQLVQCINWKTSY....SQ---PILLLKGVG.TKCWAPEAEY.......GLHALYQGGLF
Q9DEP9_ONCMY/121-255GPGE............RT.TPLSHVIWRYSDSI....GD---KGNLLSGVR.SVCQQNYGNDESNIGEGWYNAVYLSAVF
TNFB_MOUSE/74-202PRAI...........PTP.IYLAHEVQLFSSQY....PF---HVPLLSAQKSVYPGLQGP.........WVRSMYQGAVF
TNFL8_HUMAN/113-230NN...............S.VDLKLELLINKH......IK---KQALVTVCE.SGMQTKH..........VYQNLSQFLLD
TNF10_MOUSE/156-290DASKMVS.....KDKVRT.KQLVQYIY.KYTSY....PD---PIVLMKSAR.NSCWSRDAEY.......GLYSIYQGGLF
TNFA_SAISC/102-233ST...............F.TLLTHSISRIAVSY....QA---KVNLLSAIK.SPCQRETPRGAK..THPWYEPIYLGGVF
TNFL4_RAT/77-185...................QEVKINLHFRKDRS....PI---FVPMLNNGQRVVFTVVTSLA.......FKDEVYLTVNA
Q69HR0_CIOIN/178-304...................TNLPFMVSEIGVNV....DG---QSTFSRCQFSNTLTRSTPRASS..TRKRFVTCHSNGIV
TNFA_MACEU/102-233NE...............P.LLLTHTVSRVALSY....QS---KVNLLSAIK.SPCQKTVKGARE..ASPWYEPIYLGGVF
TNFL9_MOUSE/164-302HK...............V.QGWVSLVLQAKPQV....DD---FDNLALTVELFPCSMENKLVD....RSWSQLLLLKAGH
Q8JG37_ICTPU/95-230AEGDET........EGEV.MHMSHKVSRWSDSY....SS---WKPLLSATR.SACKKTTEEYQ....KYWYGAVYLGAAF
TNFB_MACEU/74-201EITP............TL.LYLSHEVLLFSSKY....QV---HVPLLSAQK.SVCSGTQGP........WMRSVYQGAVF
Q800J1_CHICK/114-232HS...............P.TDLKIELLINNE......VN---RQTLSTWCASDSCQEK...........NFKTLFQLHLT
CD70_MOUSE/75-193SPGS...........TLQ.HRATLAVGICSPA.....AH---GISLLRGRFGQDC.................TVALQRLT
CD70_HUMAN/73-191STTA...........SRH.HPTTLAVGICSPA.....SR---SISLLRLSFHQGC.................TIASQRLT
Q6T9C7_DANRE/102-234SELT...........EEQ.VLMSHAVMRFSESY....GG---KKPLFSAIR.SICTQEPESEN.....LWYNTIYLGAAF
TNFL8_MOUSE/118-235NH...............S.VDLTLQLLINSK......IK---KQTLVTVCE.SGVQSKN..........IYQNLSQFLLH
TNFC_MACEU/101-249GGEQFRS.....QAGDPG.VPVTLSSQLFRARGASGSGE---PELLLQGFETVTPPVQHARGVGQ.GPLWYATVGFGGLV
Q6U817_LATJA/102-241NGDEEG.......AGKGL.TPLSHRIWRYSDSI....GS---KASLVSAVR.SACQSTTQEDSYRAGQGWYNTIYLGAVF
EDA_MOUSE/272-385...................YYINFTDFASYEVV....VD---EKPFLQCTR.SIETGKT..........NYNTCYTAGVC
Q7T1F2_CHICK/156-290DEDSGLL.....ERIKNP.KQLVQYIYKLTNY.....PD---PILLMKSAR.TSCWSKKAEY.......GLYSVYQGGVF
Q9IB41_PAROL/83-225SDDADDGK...EAAEKHL.TSISHRVWLFTESL....GT---QVSLMSAVR.SACQKSQEDAYRD.GQGWYNAIYLGAVF
TNFC_HUMAN/102-243GGGDP.........QGRS.VTLRSSLYRAGGAYG..PGT---PELLLEGAE.TVTPVLDPARRQGYGPLWYTSVGFGGLV
B2RR33_MOUSE/118-252CGDISRG.....RRPNKP.DSITMVITKVADSY....PE---PARLLTGSK.SVCEISNN.........WFQSLYLGATF
CD40L_MOUSE/137-260SS...............Q.RPFIVGLWLKPSS.....GS---ERILLKAANTHSSSQLC..........EQQSVHLGGVF
TNFL4_RABIT/81-186...................QEVSISLHYRKG......EE---PFPILKKTKFANSNVVLKLG.......YKDKVYLNVTT
TNF12_HUMAN/131-248...................VYLKLDLL..........VD---GVLALRCLEEFSATAASSLG......PQLRLCQVSGLL
TNFB_HUMAN/77-205PKAT...........SSP.LYLAHEVQLFSSQY....PF---HVPLLSSQKMVYPGLQEP.........WLHSMYHGAAF
TNFL4_HUMAN/77-182...................QEVNISLHYQKDEE....PL---FQ..LKKVRSVNSLMVASLT.......YKDKVYLNVTT
Q6DHG9_DANRE/158-298EDESAREDEYGSMGESVRGKPMLQYVYKKVSSY....QV---PILLMKNAR.TTCWSRDSEY.......GLYSIYQAGLF
TNFC_MOUSE/168-305AGRSR..........ARS.LTLRSALYRAGGAYG..RGS---PELLLEGAE.TVTPVVDPIGYG...SLWYTSVGFGGLA
Q7ZYX9_DANRE/187-315DSDQS..........SVS.HQLVQCIYKKTSY.....LN---PIQLLKGVG.TKCWAPDAEY.......ALHSVYQGGLF
TNFA_CAPHI/103-234ST...............P.LFLTHTISRIAVSY....QT---KVNILSAIK.SPCHRETPEGAE..AKPWYEPIYQGGVF
TNFL9_HUMAN/107-240.................S.VSLALHLQPLRSA.....AG---AAALALTVDLPPASSEAR.........NSAFGFQGRLL
TNF11_HUMAN/185-313GDLA...........TEY.LQLMVYVTKTSIKI....PS---SHTLMKGGS.TKYWSGNSEF.......HFYSINVGGFF
CD40L_FELCA/137-260SS...............Q.APFIASLCLHSPS.....GS---ERVLLRAANARSSSKPC..........GQQSIHLGGVF
TNF14_MOUSE/110-239QGLA............NG.LPITHGLYKRTSRY....PK---ELELLVSRR.SPCGRANSSR......VWWDSSFLGGVV
TNF13_HUMAN/136-250...................FTMGQVVSREGQ......GR---QETLFRCIRSMPSHPDR..........AYNSCYSAGVF
Q8IGD3_DROME/300-409NS...............H.DQNGFIVF..........QG---DTPFLQCLNTVPTNMPH..........KVHTCHTSGLI
CD40L_CHICK/152-272...................APFTLYIYLYLPM.....EE---DRLLMKGLDTHSTSTALC.........ELQSIREGGVF
TNFL6_RAT/157-278.................S.QPLSHKVYMRNFKY....PG---DLVLMEEKKLNYCTTGQI.........WAHSSYLGAVF
Q8AW02_CYPCA/97-231HDMTE.........DQDV.VHMSHAVLRYSESY....GS---YKPLFSAIR.SACVHASDSED.....LWYNTIYLGAAF
TNFA_LAMGL/102-233ST...............P.VFLTHTISRLAVSY....PN---KANLLSAIK.SPCQGGTSEEAE..AKPWYEPIYLGGVF
TNFA_RABIT/105-235S................Y.VLLTHTVSRFAVSY....PN---KVNLLSAIK.SPCHRETPEEAE..PMAWYEPIYLGGVF
Q6DI63_MOUSE/142-243...................VHLNLNLARVA.........---..........SFCDHMFN.........SKQVSSGGVLL
Q8AWC9_CYPCA/103-237TNMTE.........DHDL.VHMSHTVLRYSDSY....GR---YMPLFSAIR.TACAQASNTDD.....LWYNTIYLGAAF
TNFA_TRIVU/102-233KE...............S.LVLTHKISRFTLSY....QK---KVTLLANIR.SSCRKAAEDDGE..PSAWYEPVYLAGVF
Q7T2Q3_CYPCA/93-227NDMTE.........DQEV.MHVSHAVFHYSDFF....GI---YKPLIRAAR.SACVHASNTED.....VWYDTIYLGAAF

PF00386

MMRN2_HUMAN/827-946-------------------FGPGPGTG.Q..LV----FG...GHHRTPVCTTGQGSG..----------..STATVFAMA
C1QT8_HUMAN/118-246-------------------TWNYKETYLH..IM----LN...RRPAAVLYAQPSERS..----------..VMQAQSLML
C1QT6_HUMAN/126-254-------------------SWNYKETYVH..IM----HN...QKEAVILYAQPSERS..----------..IMQSQSVML
Q7T129_DANRE/91-222-------------------THDALSAGVK..LL----KN...DDHVVGVTDNPPTED..----------KEDTASNSVSL
Q7T137_DANRE/76-204-------------------CHGGTTMAIS..LQ----KN...GVTQCSVHAWKPTSN..----------..GNGSNGVVL
MMRN2_MOUSE/821-940-------------------FGPGPGMG.Q..LV----FE...GHHRVPVYSTEQRGG..----------..STATTFAMV
CAPR2_DANRE/786-911-------------------LAISVPLYIN..LM----RN...EEVMVSAYANDGAPD..----------.HETASNHAVL
C1T9A_HUMAN/203-329-------------------.VFSRNVQVS..LV----KN...GVKILHTKDAYMSSE..----------..DQASGGIVL
MMRN1_HUMAN/1102-1225-------------------SAHISGF.....LV----VD...GIDKLAFESENINSEIH----------CDRVLTGDALL
Q70SH0_9EUPU/26-150-------------------TSLQSNLWLA..LY----HN...DNYVFSIYGRQTEYS..----------..DGGANAAIL
C1QT4_MOUSE/30-155-------------------KAPHKSLSVM..LV----RN...RDEVQALAFDEQRRPG.----------ARRAASQSAML
C1QC_HUMAN/121-242-------------------..HTANLCVL..LY----RS...GVKVVTFCGHTSKTN..----------..QVNSGGVLL
C1QT4_MOUSE/176-309-------------------KLPRKTLSVK..LM----KN...RDEVQAMIYDDGASR..----------RREMQSQSVML
C1QA_HUMAN/116-241-------------------WEICLSIVSS..SR----GQ...VRRSLGFCDTTNKGL..----------.FQVVSGGMVL
C1QA_PIG/118-243-------------------WDLCLYIMSS..RR----DQ...VQQSLGFCDFNSKGL..----------.FQVVSGGTVL
Q7T126_DANRE/61-194-------------------GNHERAVTAG..LF----KN...DQHIVSTHGHQADGF..----------..ISSSNGVSL
C1QL3_MOUSE/128-252-------------------GGDGTSMWAD..LC----KN...NQVRASAIAQDADQN..----------.YDYASNSVVL
C1QA_MOUSE/116-241-------------------WDLCLFIKSS..SG----GQ...PRDSLSFSNTNNKGL..----------.FQVLAGGTVL
Q6LA35_LAMJA/119-237-------------------.PSEQHLVIM..FM----KN...GKVISKVCGEKYNAI..----------.....SGSVVV
Q6PP07_PIG/113-238-------------------.VYLKDVKVS..LY----KK...DKAVLFTYDQYQDKN..----------.VDQASGSVLL
Q6UQ16_MYTED/109-235-------------------RDSILEMA....LH----VN...DHDEMIIHADAEHLE..----------.LGCASNSEIV
CO8A2_MOUSE/572-696-------------------.VKGTNVWVA..LY----KN...NVPATYTYDEYKKGY..----------.LDQASGGAVL
D6R934_HUMAN/121-245-------------------..SRGNLCVN..LM----RGRERAQKVVTFCDYAYNTF..----------..QVTTGGMVL
Q6DBS9_DANRE/118-238-------------------QSACLKIQVG....----.....AEEKVKFCDSPKLIS..----------...GTAASVVL
Q9PT14_ONCMY/45-176-------------------NSGKANAA....LL----KN...DVKMVAVYETANPKSG.----------IYHGGANGVTL
HP27_TAMSI/91-212-------------------.AVQRAVKVS..LM----RN...GTQVMEREAEAQDGY..----------..EHISGTAIL
HP20_TAMSI/73-194-------------------.LYHCKVKIG..LM----KN...HIQVMEKHQLSKNEY..----------..ENASGAMIM
Q6DJ45_XENTR/107-232-------------------.VYMKDVKVG..LY----RN...NKPVMFTFDQFQSNN..----------.VDQASGSVLL
HP25_TAMSI/91-212-------------------.LFQSSVKIR..LM----RD...GIQVREKEAQANDSY..----------..KHAMGSVIM
Q6L7J6_CYPCA/48-176-------------------.VYRSSLQFD..LI----KN...GHTVASYFQIFGNWS..----------KPASLSGGTLA
OTOL1_ONCKE/377-502-------------------.VRNRPLRAA..LV----IN...GVKKLRTRDSLYGQD..----------.IDQASNLALL
Q8JI26_SALFO/92-219-------------------GSQVKYIX....LF----KN...GQRMISSSDHQCSSD..----------GADNGANAVTL
Q9GQV4_STRPU/36-175-------------------TMDEETRVELFKLE----AGKDLKSATLQVFQSITPALVS----------PLDSASASVMV
Q6QWE7_CHICK/112-237-------------------.VYMTDVKVS..LY----KK...DKAVIFTYDQFQENN..----------.VDQASGSVLL
Q6PS61_CARAU/82-210-------------------GGTTMAVS....LL----KN...GKTQCSVFAWKPTSN..----------..GNGSNGVVL
C1QC_MOUSE/122-243-------------------..HTANLCVH..LN----LN...LARVASFCDHMFNSK..----------..QVSSGGALL
CO8A1_RABIT/617-741-------------------.CKGGNVWVA..LF----KN...NEPVMYTYDEYKKGF..----------.LDQASGSAVL
Q6GPX5_XENLA/123-244-------------------..HSANLCAA..LY----VD...GKATSSFCDHMSSKS..----------..QVASGGVLV
COAA1_BOVIN/547-671-------------------.VKGTHAWVG..LY----KN...GTPVMYTYDEYIKGY..----------.LDQASGSAVI
Q7T128_DANRE/102-228-------------------GSPDKAVVAG..LF----KN...GQHEISTYARQSGGF..----------..VGSSNGVSL
C1QT5_MOUSE/105-232-------------------.VYRASLQFD..LV----KN...GQSIASFFQYFGGWP..----------KPASLSGGAMV
C1QT2_HUMAN/151-275-------------------.LANKHLAIG..LV----HN...GQYRIRTFDANTGNH..----------..DVASGSTIL
Q8R1P2_MOUSE/48-176-------------------NQKETYLH....IM----KN...EEEVVILYAQVSDRS..----------..IMQSQSLMM
C1QT3_MOUSE/119-242-------------------HEDVEEVYVY..LM----HN...GNTVFSMYSYETKGK..----------.SDTSSNHAVL
Q6NUY7_DANRE/772-890-------------------.GTRSLGFVT..LK----KN...NRVELTPETVALNTR..----------..SLAEGKAVL
C1QT7_MOUSE/149-273-------------------.LANKHLAIG..LV----HN...GQYRIRTFDANTGNH..----------..DVASGSTVI

PF00229

TNF18_MOUSE/61-166ELHAGDNIYLK..FN..SK---DHIQKT....NTYWGIILM
TN13B_MOUSE/190-308RLEEGDEIQLA..IP..RE---NAQISRN.GDDTFFGALKL
TNF15_HUMAN/117-251SLQEGDKLMVN..VS..DI---SLVDYTK.EDKTFFGAFLL
TNF10_HUMAN/152-280ELKENDRIFVS..VT..NE---HLIDMD..HEASFFGAFLV
Q90WT9_CHICK/158-285ELKAGDELFVS..VS...S---LAIDYSD.AAASYFGAFRL
Q9DEP9_ONCMY/121-255QLNEGDKLWTE..TN..RL---TDVEPE..QGKNFFGVFAL
TNFB_MOUSE/74-202LLSKGDQLSTH..TD..GI---SHLHFS..PSSVFFGAFAL
TNFL8_HUMAN/113-230YLQVNTTISVN..VD..TF---QYIDTSTFPLENVLSIFLY
TNF10_MOUSE/156-290ELKKNDRIFVS..VT..NE---HLMDLD..QEASFFGAFLI
TNFA_SAISC/102-233QLEKGDRLSAE..IS..PP---DSLDLAE.SGQVYFGIIAL
TNFL4_RAT/77-185SDTLCEHLQIN..DG..EL---IIVQLTP.......NGYCA
Q69HR0_CIOIN/178-304YMKANHGVSLS..VN..PP---SVEVFLA.PQYTYFGAFLI
TNFA_MACEU/102-233QLEKGDKLSAD..TN..YP---NYLDFAE.SGQVYFGVIAL
TNFL9_MOUSE/164-302RLSVGLRAYLHGAQD..AY---RDWELSY.PNTTSFGLFLV
Q8JG37_ICTPU/95-230NLKAGDRLRTV..MDEKLL---PKVESA..GGKTFFGTFSL
TNFB_MACEU/74-201LLTQGDRLSTY..TD..GV---SHLLQS..PSSVFFGAFAL
Q800J1_CHICK/114-232YLKEEDRISST..LS..HP---KFLNEIHLPNDNVLGVLRY
CD70_MOUSE/75-193YLVHGDVLCTN......LT---LPLLPSRNADETFFGVQWI
CD70_HUMAN/73-191PLARGDTLCTN......LT---GTLLPSRNTDETFFGVQWV
Q6T9C7_DANRE/102-234HLREGDRLGTD..TTTALL---PMVEND..NGKTFFGVFGL
TNFL8_MOUSE/118-235YLQVNSTISVR..VD..NF---QYVDTNTFPLDNVLSVFLY
TNFC_MACEU/101-249QLRGGEKIYVN..VS..HL---ELVDFR..RGKTFFGAVMV
Q6U817_LATJA/102-241QLNRGDRLWTE..TN..QP---SELETD..EGKTFFGVFAL
EDA_MOUSE/272-385LLKARQKIAVK..MV..HA---DISINMS.KHTTFFGAIRL
Q7T1F2_CHICK/156-290QLKREDRIFVS..VS..NS---DIVDMD..KEASFFGAFMI
Q9IB41_PAROL/83-225QLNEGDKLWTE..TN..ML---SELETE..SGKTFFGVFAL
TNFC_HUMAN/102-243QLRRGERVYVN..IS..HP---DMVDFA..RGKTFFGAVMV
B2RR33_MOUSE/118-252SLEEGDRLMVN..VS..DI---SLVDYTK.EDKTFFGAFLL
CD40L_MOUSE/137-260ELQAGASVFVN..VT..EA---SQVIHR..VGFSSFGLLKL
TNFL4_RABIT/81-186DSASCKQLSVN..AG..EL---IVILQN.......PGGYCA
TNF12_HUMAN/131-248ALRPGSSLRIR......TL---PWAHLKAAPFLTYFGLFQV
TNFB_HUMAN/77-205QLTQGDQLSTH..TD..GI---PHLVLS..PSTVFFGAFAL
TNFL4_HUMAN/77-182DNTSLDDFHVN..GG..EL---ILIHQNP.......GEFCV
Q6DHG9_DANRE/158-298QLGSGDRVFVT..VS..NV---STIDMD..EKSSFFGAFLV
TNFC_MOUSE/168-305QLRSGERVYVN..IS..HP---DMVDYR..RGKTFFGAVMV
Q7ZYX9_DANRE/187-315ELRAGDEVFVS..VS..SP---TMVYGE..DSSSYFGAFRL
TNFA_CAPHI/103-234QLEKGDRLSAE..IN..QP---EYLDYAE.SGQVYFGIIAL
TNFL9_HUMAN/107-240HLSAGQRLGVH..LHTEAR---ARHAWQLTQGATVLGLFRV
TNF11_HUMAN/185-313KLRSGEEISIE..VS..NP---SLLDPD..QDATYFGAFKV
CD40L_FELCA/137-260ELHPGASVFVN..VT..DP---SQVSHG..TGFTSFGLLKL
TNF14_MOUSE/110-239HLEAGEEVVVR..VP..GN---RLVRPRD.GTRSYFGAFMV
TNF13_HUMAN/136-250HLHQGDILSVI..IP..RA---RAKLNLS.PHGTFLGFVKL
Q8IGD3_DROME/300-409HLERNERIHLK.DIH..ND---RNAVLREGNNRSYFGIFKV
CD40L_CHICK/152-272ELRQGDMVFVN..VT..DS---TAVNVN..PGNTYFGMFKL
TNFL6_RAT/157-278NLTVADHLYVN..IS..QL---SLINFE..ESKTFFGLYKL
Q8AW02_CYPCA/97-231NLRARDRLRTE..TTKELL---PRVESE..NGKTFFGVFAL
TNFA_LAMGL/102-233QLEKDDRLSAE..IN..MP---NYLDFAE.SGQVYFGIIAL
TNFA_RABIT/105-235QLEKGDRLSTE..VN..QP---EYLDLAE.SGQVYFGIIAL
Q6DI63_MOUSE/142-243RLQRGDEVWLS..VN..DY---NGMVGIE.GSNSVFSGFLL
Q8AWC9_CYPCA/103-237KLRAGDRLRTE..TTEELL---PSVETG..DGKTFFGVFAL
TNFA_TRIVU/102-233QLTEGDKLVVD..TN..YP---ENLDFAE.PGQLYFGAIAL
Q7T2Q3_CYPCA/93-227SLRAGDKLCTK..TTTELL---PRVETD..NAKTFFGVFAL

PF00386

MMRN2_HUMAN/827-946ELQKGERVWFE--LT--.....QGSITKRSLSGTAFGGFLM
C1QT8_HUMAN/118-246LLAAGDAVWVR--MF--QRDRDNAIYGEHGDLYITFSGHLV
C1QT6_HUMAN/126-254DLAYGDRVWVR--LF--KRQRENAIYSNDFDTYITFSGHLI
Q7T129_DANRE/91-222LLEEGDQISVK--LI--AH...RRIYTDGF.RRNTFSGHLL
Q7T137_DANRE/76-204TLEPGDQMYTK--LW--RN...TWVYDDIA.SYTSFSGFLI
MMRN2_MOUSE/821-940ELQKGERAWFE--LI--.....QGSATKGSQPGTAFGGFLM
CAPR2_DANRE/786-911QLFQGDQVWLR--LH--.....RGAIYGSSWKYSTFSGFLL
C1T9A_HUMAN/203-329QLKLGDEVWLQ--VT--GGERFNGLFADED.DDTTFTGFLL
MMRN1_HUMAN/1102-1225ELNYGQEVWLR--LA--.....KGTIPAKFPPVTTFSGYLL
Q70SH0_9EUPU/26-150PLKKGDKVHVK--AR--DK...SSLLGRPDNIYTTFTGFRL
C1QT4_MOUSE/30-155QLDYGDTVWLR--LH--.....GAPQYALGAPGATFSGYLV
C1QC_HUMAN/121-242RLQVGEEVWLA--VN--DY...YDMVGIQG.SDSVFSGFLL
C1QT4_MOUSE/176-309PLRRGDAVWLL--SH--DHDGYGA..YSNHGKYITFSGFLV
C1QA_HUMAN/116-241QLQQGDQVWVE--KD--PK...KGHIYQGSEADSVFSGFLI
C1QA_PIG/118-243QLQRGDKVWIQ--RD--PN...KGRIYQGSEADSVFSGFLI
Q7T126_DANRE/61-194LLDEGDKMKVN--LY--PG...QWIFDNGEHHHSTFSGHLL
C1QL3_MOUSE/128-252HLEPGDEVYIK--LD--G....GKAHGGNNNKYSTFSGFII
C1QA_MOUSE/116-241QLRRGDEVWIE--KD--PA...KGRIYQGTEADSIFSGFLI
Q6LA35_LAMJA/119-237SLKAGDEVWLE--LE--AP...YINFYFNVHRDSVFSGYIL
Q6PP07_PIG/113-238YLEKGDQVWLQ--AY--GDEENNGVYADNV.NDSIFTGFLL
Q6UQ16_MYTED/109-235HLQKGDHVEVV--KH--GA...DGVPPFYIHTMSTFTGFML
CO8A2_MOUSE/572-696QLRPNDQVWVQ--MP--SDQ.ANGLYSTEY.IHSSFSGFLL
D6R934_HUMAN/121-245KLEQGENVFLQ--AT--DK...NSLLGMEG.ANSIFSGFLL
Q6DBS9_DANRE/118-238KLNKGDKVSVQ--SI--GE...STVFSRD..TDCTFTGFML
Q9PT14_ONCMY/45-176DLVKGDKVNVV--LW--SG...SSMFDNS..RINMFSGYLL
HP27_TAMSI/91-212QLGMEDRVWLE--NK--L....SQTDLERGTVQAVFSGFLI
HP20_TAMSI/73-194PLRQGDKVWLE--AD--V....ETEEPDQAKVVIYFSGFLI
Q6DJ45_XENTR/107-232HLEVGDEVWLQ--IY--GDESFSGIYGDNL.NDSTFTGILL
HP25_TAMSI/91-212ALGKGDKVWLE--SK--L....KGTESEKGITHIVFFGYLL
Q6L7J6_CYPCA/48-176HLIPGDQVWVQ--MA--LGE.YTGFYSSPK.TDSTFTGFLV
OTOL1_ONCKE/377-502RLASGDQVWLE--TL--RD..WNGVYSSSE.DDSTFTGFLL
Q8JI26_SALFO/92-219QLEVGDQVFIR--LM--AN...THVWDSV..NHTTFNGFLL
Q9GQV4_STRPU/36-175ELKRDDEVFLR--LA--.....PGLLDADADRPLLFTGYLV
Q6QWE7_CHICK/112-237HLSLGDEVWLQ--VY--GEGNNNGVYADNI.NDSTFMGFLL
Q6PS61_CARAU/82-210TLEIGDQISTQ--LW--DN...TWVYDDPA.SYTSFGGFLI
C1QC_MOUSE/122-243RLQRGDEVWLS--VN--DY...NGMVGIEG.SNSVFSGFLL
CO8A1_RABIT/617-741LLRPGDRVFLQ--MP--SEQ.AAGLYAGQY.VHSSFSGYLL
Q6GPX5_XENLA/123-244SLAGGQEVWME--VN--DY...NGMIGTEG.NDSVFSGFLV
COAA1_BOVIN/547-671DLTENDQVWLQ--LP--NAG.SNGLYSPEY.VHSSFSGFLV
Q7T128_DANRE/102-228LLEKGDKVNVN--LY--SG...HWIFDNEH.HHSTFSGHLL
C1QT5_MOUSE/105-232RLEPEDQVWVQ--VG--VGD.YIGIYASIK.TDSTFSGFLV
C1QT2_HUMAN/151-275ALKQGDEVWLQ--IF--YSE.QNGLFYDPYWTDSLFTGFLI
Q8R1P2_MOUSE/48-176ELREEDEVWVR--LF--KGERENAIFSDEFDTYITFSGYLV
C1QT3_MOUSE/119-242KLAKGDEVWLR--MG--.....NGALHGDHQRFSTFAGFLL
Q6NUY7_DANRE/772-890SLQRGDRVYVE--VS--RS.......ANGIGFSSYFSGHIL
C1QT7_MOUSE/149-273YLQPEDEVWLE--IF--FND.QNGLFSDPGWADSLFSGFLL

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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