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1333  structures 7405  species 52  interactions 84398  sequences 1965  architectures

Clan: Gal_mutarotase (CL0103)


Galactose Mutarotase-like superfamily Add an annotation

This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase [1]. All these enzymes act on a sugar substrate.

This clan contains 32 families and the total number of domains in the clan is 84398. The clan was built by A Bateman.

Literature references

  1. Thoden JB, Holden HM; , J Biol Chem 2002;277:20854-20861.: High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. PUBMED:11907040 EPMC:11907040


This clan contains the following 32 member families:

Aldose_epim Bgal_small_N Cu_amine_oxid DUF1926 DUF4432 DUF4450 DUF4968 DUF5054 DUF5107 DUF5127 DUF5703_N Gal_mutarotas_2 Gal_mutarotas_3 GH97_N Glucodextran_N Glyco_hyd_65N_2 Glyco_hydr_116N Glyco_hydro_36N Glyco_hydro_38 Glyco_hydro_38C Glyco_hydro_52 Glyco_hydro_65N Glyco_hydro_81 Glyco_hydro_92N Glyco_transf_36 Hepar_II_III Lyase_8 MdoG NtCtMGAM_N Rhamnogal_lyase RhgB_N YidC_periplas

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Aldose_epim (PF01263) 14506 (17.2%) View
Gal_mutarotas_2 (PF13802) 8047 (9.5%) View
Glyco_hydro_38C (PF07748) 6279 (7.4%) View
Glyco_hydro_92N (PF17678) 5992 (7.1%) View
Cu_amine_oxid (PF01179) 5641 (6.7%) View
Bgal_small_N (PF02929) 4040 (4.8%) View
Hepar_II_III (PF07940) 3850 (4.6%) View
Glyco_hyd_65N_2 (PF14498) 3705 (4.4%) View
YidC_periplas (PF14849) 3556 (4.2%) View
Glyco_hydro_65N (PF03636) 3387 (4.0%) View
NtCtMGAM_N (PF16863) 3190 (3.8%) View
Glyco_hydro_36N (PF16875) 3031 (3.6%) View
Glyco_transf_36 (PF06165) 2726 (3.2%) View
GH97_N (PF14508) 2134 (2.5%) View
DUF4968 (PF16338) 1883 (2.2%) View
Glyco_hydr_116N (PF12215) 1728 (2.0%) View
DUF5127 (PF17168) 1523 (1.8%) View
Pfam family Num. domains Alignment
MdoG (PF04349) 1521 (1.8%) View
Glyco_hydro_81 (PF03639) 1403 (1.7%) View
Lyase_8 (PF02278) 1281 (1.5%) View
Rhamnogal_lyase (PF06045) 1166 (1.4%) View
DUF5107 (PF17128) 768 (0.9%) View
DUF4432 (PF14486) 760 (0.9%) View
RhgB_N (PF09284) 560 (0.7%) View
Glucodextran_N (PF09137) 380 (0.5%) View
Gal_mutarotas_3 (PF18080) 263 (0.3%) View
DUF5703_N (PF18961) 228 (0.3%) View
Glyco_hydro_38 (PF18438) 221 (0.3%) View
DUF1926 (PF09095) 214 (0.3%) View
DUF5054 (PF16477) 168 (0.2%) View
DUF4450 (PF14614) 130 (0.2%) View
Glyco_hydro_52 (PF03512) 117 (0.1%) View
Total: 32 Total: 84398 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...