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539  structures 4717  species 11  interactions 24927  sequences 313  architectures

Clan: Gal_mutarotase (CL0103)


Galactose Mutarotase-like superfamily Add an annotation

This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase [1]. All these enzymes act on a sugar substrate.

This clan contains 11 families and the total number of domains in the clan is 24927. The clan was built by A Bateman.

Literature references

  1. Thoden JB, Holden HM; , J Biol Chem 2002;277:20854-20861.: High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. PUBMED:11907040 EPMC:11907040


This clan contains the following 11 member families:

Aldose_epim Bgal_small_N DUF4432 Gal_mutarotas_2 Glyco_hyd_65N_2 Glyco_hydro_38C Glyco_hydro_65N Lyase_8 MdoG Rhamnogal_lyase YidC_periplas

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Aldose_epim (PF01263) 8201 (32.9%) View
Gal_mutarotas_2 (PF13802) 2671 (10.7%) View
Glyco_hydro_38C (PF07748) 2571 (10.3%) View
Bgal_small_N (PF02929) 2500 (10.0%) View
YidC_periplas (PF14849) 2338 (9.4%) View
Glyco_hydro_65N (PF03636) 1768 (7.1%) View
MdoG (PF04349) 1625 (6.5%) View
Glyco_hyd_65N_2 (PF14498) 1312 (5.3%) View
Lyase_8 (PF02278) 1067 (4.3%) View
DUF4432 (PF14486) 706 (2.8%) View
Rhamnogal_lyase (PF06045) 168 (0.7%) View
Total: 11 Total: 24927 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
MdoG MdoG
Aldose_epim Aldose_epim
Bgal_small_N Glyco_hydro_2_C
Glyco_hydro_38C Glyco_hydro_38
Lyase_8 Lyase_8_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...