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532  structures 8253  species 14  interactions 105277  sequences 392  architectures

Clan: Glyoxalase (CL0104)


VOC superfamily Add an annotation

This clan contains the VOC metalloenzyme superfamily [1]. The known types of reactions that are catalysed include isomerizations (glyoxalase I), epimerizations (methylmalonyl-CoA epimerase), oxidative cleavage of C-C bonds (extradiol dioxygenase), and nucleophilic substitutions (fosfomycin resistance proteins) [1].

This clan contains 12 families and the total number of domains in the clan is 105277. The clan was built by A Bateman.

Literature references

  1. Armstrong RN; , Biochemistry 2000;39:13625-13632.: Mechanistic diversity in a metalloenzyme superfamily. PUBMED:11076500 EPMC:11076500


This clan contains the following 12 member families:

3-dmu-9_3-mt CppA_C CppA_N DUF1338 Glyoxalase Glyoxalase_2 Glyoxalase_3 Glyoxalase_4 Glyoxalase_5 Glyoxalase_6 TxDE YecM

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glyoxalase (PF00903) 64893 (61.6%) View
Glyoxalase_6 (PF18029) 16417 (15.6%) View
Glyoxalase_4 (PF13669) 8363 (7.9%) View
3-dmu-9_3-mt (PF06983) 6659 (6.3%) View
Glyoxalase_5 (PF14696) 2924 (2.8%) View
Glyoxalase_3 (PF13468) 2448 (2.3%) View
DUF1338 (PF07063) 1726 (1.6%) View
Glyoxalase_2 (PF12681) 1266 (1.2%) View
YecM (PF06185) 332 (0.3%) View
CppA_C (PF14507) 102 (0.1%) View
CppA_N (PF14506) 81 (0.1%) View
TxDE (PF18711) 66 (0.1%) View
Total: 12 Total: 105277 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
3-dmu-9_3-mt 3-dmu-9_3-mt
CppA_C CppA_N
CppA_N CppA_C
DUF1338 DUF1338
Glyoxalase Glyoxalase
Glyoxalase_2 Glyoxalase
Glyoxalase_4 Glyoxalase
Glyoxalase_5 Glyoxalase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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