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489  structures 21563  species 58  interactions 638529  sequences 981  architectures

Clan: Hybrid (CL0105)


Barrel sandwich hybrid superfamily Add an annotation

This superfamily contains proteins with a hybrid motif [1]. This motif is embedded in structurally diverse proteins.

This clan contains 19 families and the total number of domains in the clan is 638529. The clan was built by A Bateman.

Literature references

  1. Chothia C, Murzin AG; , Structure 1993;1:217-222.: New folds for all-beta proteins. PUBMED:8081735 EPMC:8081735


This clan contains the following 19 member families:

Apocytochr_F_C Biotin_lipoyl Biotin_lipoyl_2 Complex1_51K DUF2118 DUF2254 GCV_H HlyD HlyD_2 HlyD_3 HlyD_D23 HlyD_D4 NQRA OEP Peptidase_M23 PTS_EIIA_1 PYNP_C QRPTase_N RnfC_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Biotin_lipoyl (PF00364) 114752 (18.0%) View
OEP (PF02321) 111802 (17.5%) View
Peptidase_M23 (PF01551) 74438 (11.7%) View
HlyD_D23 (PF16576) 72553 (11.4%) View
Biotin_lipoyl_2 (PF13533) 64774 (10.1%) View
HlyD_3 (PF13437) 47218 (7.4%) View
PTS_EIIA_1 (PF00358) 43733 (6.8%) View
GCV_H (PF01597) 22930 (3.6%) View
HlyD (PF00529) 20871 (3.3%) View
Complex1_51K (PF01512) 20024 (3.1%) View
PYNP_C (PF07831) 13907 (2.2%) View
QRPTase_N (PF02749) 13693 (2.1%) View
RnfC_N (PF13375) 7476 (1.2%) View
HlyD_D4 (PF16572) 3489 (0.5%) View
DUF2254 (PF10011) 3029 (0.5%) View
NQRA (PF05896) 2351 (0.4%) View
Apocytochr_F_C (PF01333) 1201 (0.2%) View
HlyD_2 (PF12700) 237 (0.0%) View
DUF2118 (PF09891) 51 (0.0%) View
Total: 19 Total: 638529 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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