Summary
Actin-like ATPase Superfamily
The actin-like ATPase domain forms an alpha/beta canonical fold. The domain can be subdivided into 1A, 1B, 2A and 2B subdomains. Subdomains 1A and 1B share the same RNAseH-like fold (a five-stranded beta-sheet decorated by a number of alpha-helices). Domains 1A and 2A are conserved in all members of this superfamily, whereas domain 1B and 2B have a variable structure and are even missing from some homologues [1]. Within the actin-like ATPase domain the ATP-binding site is highly conserved. The phosphate part of the ATP is bound in a cleft between subdomains 1A and 2A, whereas the adenosine moiety is bound to residues from domains 2A and 2B[1].
This clan contains 34 families and the total number of domains in the clan is 265249. The clan was built by RD Finn.
Literature references
- Abendroth J, Bagdasarian M, Sandkvist M, Hol WG; , J Mol Biol 2004;344:619-633.: The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily. PUBMED:15533433 EPMC:15533433
Members
This clan contains the following 34 member families:
Acetate_kinase Actin Actin_micro ALP_N AnmK BcrAD_BadFG Carbam_trans_N DDR DUF1464 DUF2229 EutA FGGY_C FGGY_N FtsA Fumble GDA1_CD39 Glucokinase Hexokinase_1 Hexokinase_2 HGD-D HSP70 Hydant_A_N Hydantoinase_A HypF_C MreB_Mbl MutL Pan_kinase Peptidase_M22 PilM_2 Ppx-GppA RACo_C_ter ROK StbA T2SSLExternal database links
CATH: | 3.30.420.40 3.40.367.20 |
SCOP: | 53067 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
HSP70 (PF00012) | 38139 (14.4%) | View |
ROK (PF00480) | 27278 (10.3%) | View |
FGGY_N (PF00370) | 25768 (9.7%) | View |
FGGY_C (PF02782) | 24861 (9.4%) | View |
Actin (PF00022) | 20085 (7.6%) | View |
Peptidase_M22 (PF00814) | 18719 (7.1%) | View |
MreB_Mbl (PF06723) | 9917 (3.7%) | View |
Ppx-GppA (PF02541) | 9563 (3.6%) | View |
FtsA (PF14450) | 9029 (3.4%) | View |
Hydantoinase_A (PF01968) | 8227 (3.1%) | View |
BcrAD_BadFG (PF01869) | 8142 (3.1%) | View |
Acetate_kinase (PF00871) | 8070 (3.0%) | View |
Hydant_A_N (PF05378) | 7799 (2.9%) | View |
Pan_kinase (PF03309) | 5535 (2.1%) | View |
Hexokinase_2 (PF03727) | 5408 (2.0%) | View |
Hexokinase_1 (PF00349) | 5127 (1.9%) | View |
GDA1_CD39 (PF01150) | 4640 (1.7%) | View |
PilM_2 (PF11104) | 4593 (1.7%) | View |
continued |
Pfam family | Num. domains | Alignment |
---|---|---|
AnmK (PF03702) | 4057 (1.5%) | View |
HGD-D (PF06050) | 3284 (1.2%) | View |
Glucokinase (PF02685) | 2753 (1.0%) | View |
Fumble (PF03630) | 2614 (1.0%) | View |
Carbam_trans_N (PF02543) | 2508 (0.9%) | View |
HypF_C (PF17788) | 1980 (0.7%) | View |
DUF2229 (PF09989) | 1737 (0.7%) | View |
RACo_C_ter (PF14574) | 1640 (0.6%) | View |
ALP_N (PF17989) | 1099 (0.4%) | View |
T2SSL (PF05134) | 1031 (0.4%) | View |
MutL (PF13941) | 650 (0.2%) | View |
EutA (PF06277) | 441 (0.2%) | View |
DDR (PF08841) | 250 (0.1%) | View |
StbA (PF06406) | 170 (0.1%) | View |
DUF1464 (PF07318) | 99 (0.0%) | View |
Actin_micro (PF17003) | 36 (0.0%) | View |
Total: 34 | Total: 265249 | Clan alignment |
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Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Interactions
There are 72 interactions for this clan. More...
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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