Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1023  structures 2460  species 19  interactions 10883  sequences 182  architectures

Clan: Calycin (CL0116)


Calycin superfamily Add an annotation

The calycin structural superfamily [1-3] includes the lipocalins, the fatty acid-binding proteins (FABPs).

This clan contains 36 families and the total number of domains in the clan is 10883. The clan was built by A Bateman.

Literature references

  1. Flower DR, North AC, Sansom CE; , Biochim Biophys Acta 2000;1482:9-24.: The lipocalin protein family: structural and sequence overview. PUBMED:11058743 EPMC:11058743
  2. Flower DR; , FEBS Lett 1993;333:99-102.: Structural relationship of streptavidin to the calycin protein superfamily. PUBMED:8224179 EPMC:8224179
  3. Flower DR, North AC, Attwood TK; , Protein Sci 1993;2:753-761.: Structure and sequence relationships in the lipocalins and related proteins. PUBMED:7684291 EPMC:7684291


This clan contains the following 36 member families:

ApoM Calycin_like CpeS CpeT CrtC DUF1794 DUF1934 DUF2147 DUF3255 DUF3598 DUF3642 DUF4488 DUF4822 DUF4847 DUF5004 His_binding Lipocalin Lipocalin_2 Lipocalin_3 Lipocalin_4 Lipocalin_5 Lipocalin_7 Lipocalin_8 Lipocalin_9 Luciferase_cat META MoaF MxiM Nitrophorin NlpE PA_decarbox Svf1 Svf1_C Triabin VDE ZinT

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lipocalin (PF00061) 2276 (20.9%) View
META (PF03724) 1287 (11.8%) View
Lipocalin_2 (PF08212) 1097 (10.1%) View
DUF1794 (PF08768) 744 (6.8%) View
DUF2147 (PF09917) 652 (6.0%) View
DUF1934 (PF09148) 533 (4.9%) View
CrtC (PF07143) 369 (3.4%) View
Lipocalin_9 (PF17186) 358 (3.3%) View
NlpE (PF04170) 341 (3.1%) View
Svf1 (PF08622) 320 (2.9%) View
Svf1_C (PF17187) 318 (2.9%) View
Lipocalin_4 (PF13648) 312 (2.9%) View
CpeT (PF06206) 253 (2.3%) View
Lipocalin_5 (PF13924) 233 (2.1%) View
CpeS (PF09367) 226 (2.1%) View
Lipocalin_7 (PF14651) 201 (1.8%) View
PA_decarbox (PF05870) 181 (1.7%) View
ZinT (PF09223) 179 (1.6%) View
DUF3598 (PF12204) 172 (1.6%) View
Pfam family Num. domains Alignment
VDE (PF07137) 126 (1.2%) View
Calycin_like (PF13944) 112 (1.0%) View
Lipocalin_8 (PF16585) 84 (0.8%) View
MoaF (PF10703) 81 (0.7%) View
ApoM (PF11032) 76 (0.7%) View
Lipocalin_3 (PF12702) 66 (0.6%) View
DUF4822 (PF16103) 61 (0.6%) View
Triabin (PF03973) 53 (0.5%) View
DUF4488 (PF14869) 37 (0.3%) View
Nitrophorin (PF02087) 33 (0.3%) View
His_binding (PF02098) 31 (0.3%) View
DUF4847 (PF16139) 28 (0.3%) View
DUF5004 (PF16395) 26 (0.2%) View
DUF3642 (PF12182) 15 (0.1%) View
MxiM (PF11441) 1 (0.0%) View
DUF3255 (PF11631) 1 (0.0%) View
Luciferase_cat (PF10285) 0 (0.0%) View
Total: 36 Total: 10883 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 19 interactions for this clan. More...

Interacting families
ApoM ApoM
CrtC CrtC
DUF1794 DUF1794
DUF3598 DUF3598
His_binding His_binding
Lipocalin fn3
Lipocalin_2 Lipocalin_2
Lipocalin_3 Lipocalin_3
Lipocalin_7 Lipocalin_7
Luciferase_3H Luciferase_cat
MACPF Lipocalin
Nitrophorin Nitrophorin
NlpE NlpE
PA_decarbox PA_decarbox
Transthyretin Lipocalin
Triabin Triabin
Trypsin Triabin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...