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269  structures 226  species 16  interactions 3521  sequences 72  architectures

Clan: uPAR_Ly6_toxin (CL0117)

Summary

uPAR/Ly6/CD59/snake toxin-receptor superfamily Add an annotation

This superfamily contains snake toxins as well as extracellular cysteine rich domains.

This clan contains 7 families and the total number of domains in the clan is 3521. The clan was built by A Bateman.

Members

This clan contains the following 7 member families:

Activin_recp BAMBI ecTbetaR2 PLA2_inh Toxin_TOLIP UPAR_LY6 UPAR_LY6_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UPAR_LY6 (PF00021) 1396 (39.6%) View
Activin_recp (PF01064) 1237 (35.1%) View
Toxin_TOLIP (PF00087) 256 (7.3%) View
UPAR_LY6_2 (PF16975) 245 (7.0%) View
ecTbetaR2 (PF08917) 143 (4.1%) View
BAMBI (PF06211) 137 (3.9%) View
PLA2_inh (PF02988) 107 (3.0%) View
Total: 7 Total: 3521 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 16 interactions for this clan. More...

Interacting families
A B
Activin_recp Activin_recp
ecTbetaR2
TGF_beta
COesterase Toxin_TOLIP
ecTbetaR2 Activin_recp
Kringle UPAR_LY6
Neur_chan_LBD Toxin_TOLIP
Somatomedin_B UPAR_LY6
TGF_beta Activin_recp
ecTbetaR2
Thiol_cytolysin UPAR_LY6
Toxin_TOLIP Neur_chan_LBD
Toxin_TOLIP
UPAR_LY6 Kringle
UPAR_LY6
V-set UPAR_LY6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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