Sequence alignment for CL0117

PF00021

LYNX1_MOUSE/59-129----------CHLCKGF...------GG--CSRP....SSCPW------------------SSTH....CV---IIATRS
LYPD3_RAT/142-224----------CYSCMGL.SR------EK--CQGAMPPVVNCYN------------------ASGRVYKGCF---DGNVTL
LY6D_HUMAN/23-93----------CHVCT...SS------SN--CKHS....VVCPA------------------SSRF....CK---TTNTVE
LY6A_MOUSE/29-105----------CYQCYGVPFE------TS--CPSI.....TCPY------------------PDGV....CV---TQEAAV
TX101_RAT/141-217----------CPTCL...AL------EP--CSSAP..SMPCAN------------------GTTQ....CY---HGKIEL
LYPD5_MOUSE/133-212----------CYACLGT.HP------ED--CSPEKSRRVQCHQ------------------DQSA....CF---QGNGRM
Q63318_RAT/29-105----------CYSCIEVPLN------AN--CSTA.....TCPY------------------SDGV....CV---SQVLEA
LY6C2_MOUSE/29-102----------CYECYGVPIE------TS--CPAV.....TCRA------------------SDGF....CI---AQNIEL
LY6G_MOUSE/6-82----------CYNCIGVPPE------TS--CNTT.....TCPF------------------SDGF....CV---ALEIEV
LY6D_MOUSE/23-93----------CHVCT...NS------AN--CKNP....QVCPS------------------NFYF....CK---TVTSVE
PSCA_HUMAN/23-93----------CYSCKAQVSN------ED--CLQV....ENCTQ------------------LGEQ....CW---TARIRA
LYPD4_HUMAN/142-233----------CPTCVGE.HM------KD--CLPNFVTTNSCPL------------------AAST....CY---SSTLKF
UPAR_HUMAN/216-294----------CYSCKGN.ST------HG--CSSEETFLIDCRG------------------PMNQ....CL---VATGTH
LY6E_MOUSE/23-99----------CFSCTDQKNN------IN--CLWP....VSCQE------------------KDHY....CI---TLSAAA
LY6I_MOUSE/29-105----------CYQCYGVPFE------TS--CPSF.....TCPY------------------PDGF....CV---AQEEEF
LY6F_MOUSE/29-105----------CYNCLGVSLG------IA--CKSI.....TCPY------------------PDAV....CI---SQQVEL
Q810N3_MOUSE/141-219----------CPVCLD..FK------GS--CNTES.NHTLCPK------------------DTK.....CY---AASLGV
UPAR_RAT/27-101----------CIQCE...SN------QD--CLVE.....ECAL------------------GQDL....CR---TTVLRE
UPAR_HUMAN/25-99----------CMQCK...TN------GD--CRVE.....ECAL------------------GQDL....CR---TTIVRL
LY6E_CHICK/23-96----------CFSCSDASSN------WA--CLTP....VKCAE------------------NEEH....CV---TTYVGV
UPAR_BOVIN/211-289----------CYSCEGN.GA------HR--CSSEETFLIDCRG------------------PMNQ....CL---EATGTK
LYPD4_MOUSE/142-233----------CPSCVGK.HD------QE--CLPSFVTTENCPF------------------AASS....CY---SSTLKF
UPAR_RAT/216-295----------CYSCEGN.ST------FG--CSYEETSLIDCRG------------------PMNQ....CL---EATGLD
LY6H_HUMAN/28-111----------CQDCTLTTNS------SH--CTPK.....QCQP------------------SDTV....CA---SVRITD
LY6E_HUMAN/23-99----------CFSCLNQKSN------LY--CLKP....TICSD------------------QDNY....CV---TVSASA
G3HYY3_CRIGR/2-74----------..QCE...DS------QN--CLVK.....ECAL------------------GQDL....CR---TTVLHE
UPAR_BOVIN/23-97----------CLQCE...NT------TS--CSVE.....ECTP------------------GQDL....CR---TTVLSV

PF00087

H9G4X1_ANOCA/21-96--------LMCFTCDNAESN------WD--CLSM----KSCAD------------------TDKY----CM...TKYFSG
F6V970_CALJA/20-87--------LSCHECSATG..------.N--CFQP----TVCRD------------------GSRY----CL....TTWTT
C3XRB6_BRAFL/33-101--------SDCKNNA.....------.S--AVAS----ETCSQ------------------NETY----CY....VLVAT
V8N389_OPHHA/3-65--------RICHK.......------.S--SFIS----ETCPD------------------GQNL----CY...LKSWCD
V8N9N7_OPHHA/22-85--------RICLTDYSK...------.V--SETI----EICPD------------------GQNF----CF....KKFPK
V8N5J6_OPHHA/76-137--------MECYRCGVT...------.G--CHLK----ITCSA------------------EETF----CY.....KWLN
H0XNS6_OTOGA/21-88--------MRCHQCIATG..------.N--CLQP----TSCQN------------------HTRY----CL....TMWNS
V8N3G9_OPHHA/22-85--------LICVKQYTI...------.F--GVTP----EICAD------------------GQNL----CY....KTWHM
V8NAR0_OPHHA/17-92--------LICITCDKVDHN------NK--CMDL----KVCDD------------------TDRY----CY...TKYFGS
G1U6Z7_RABIT/21-88--------LRCHECTAVG..------.N--CVQP----ITCQD------------------ATRY----CL....TTWNS
V8N4I1_OPHHA/22-77--------LICH........------.R--VHGL----QTCEP------------------DEKF----CFRKTTMFFPN
H0WCF0_CAVPO/21-88--------LQCHECFATE..------.D--CFQP----VSCPA------------------NTRY----CL....TTWNS

PF02988

Q9PU34_9SAUR/20-103--------HSCEICHNFGKD------CQ--SEEA----KECAS------------------PEDQ----CG---TVLMEV
Q9PTC5_PSETE/20-102--------LECDICIGLGRE------CN--T.WT----KTCDA------------------NQDA----CV---TFQTEV
PLI_CRODU/20-102--------RSCDFCHNIGKD------CD--G.YE----EECSS------------------PEDV----CG---KVLLEI
PLIB_ELAQU/20-102--------IDCEHCVVWGQN------CT--G.WK----ETCGE------------------NEDT----CV---TYQTEV
PLIA_ELAQU/20-103--------RSCEICHNVGND------CG--YDYV----EECHS------------------PEDQ----CG---KVLLEI

PF16975

U3IGH3_ANAPL/42-147-TTPFPHGFKCFTCEKAADN------YE--CNR.WAPDVYCPR------------------GTRY----CF---SQHMMK
F7E963_XENTR/52-157-PTPFPNSFKCFTCDKAKDN------YL--CNR.WAEDKWCPQ------------------HTHF----CK---TVHHFN
U3KHG3_FICAL/185-290-PTPFPNSFKCFTCDNAVDN------YN--CNR.WAEDRWCPA------------------STRY----CL---TAHLFT
LPD6B_MOUSE/58-163-PTPFPNSFKCFTCENAGDN------YN--CNR.WAEDKWCPQ------------------DTQY----CL---TVHHFT
F7GBQ8_MONDO/39-144-PTPFPNSFKCFTCENAADN------YN--CNR.WAEDKWCPQ------------------NTQY----CL---TVHHFT
M3XHD6_LATCH/2-108-.TPFLYSFKCFTCDSAPDN------YN--CNR.WAEDKWCPQ------------------DTDY----CL---TIHHFT
F7CHM5_ORNAN/40-144-TTPYPGGFKCFTCEKAADN------YD--CNR.WAPDVYCPR------------------EARY----CY---TQHTMA
F1R757_DANRE/34-138-ATPYPKSFKCFTCEQASDN------YS--CNR.WAEDVWCPQ------------------NTQY----CM---TIHHFN
F7FWP8_MACMU/40-145-TTPYPGGFKCFTCEKAADN------YE--CNR.WAPDIYCPR------------------ETRY----CY---TQHTME
A8WGG8_XENTR/40-145-TTPYPGGFKCFTCEKAADN------YD--CNR.WAPDIFCPR------------------ETRY----CY---TQHIMN
R4GHW2_CHICK/40-145-PTPFPNSFKCFTCDNAVDN------YN--CNR.WAEDRWCPE------------------STQY----CL---TVHLFT
M4A0F0_XIPMA/40-140-TTPHPGGFKCFTCQDAADN------YN--CNKSFLPD.....------------------.TSY----CY---TLHMMD
H9G7P9_ANOCA/40-145-TTPYPGGFKCFTCEQAVDN------YE--CNQ.WAPDIYCPR------------------VTRY----CY---TQHTLE
H9G7N5_ANOCA/44-149-PTPYPSSFKCFTCDNVVDN------YN--CNR.WAEDKWCPQ------------------NTQY----CL---TVHHFT
H3AJQ0_LATCH/40-145-TTPYPGGFKCFTCENASDN------YE--CNR.WAPDVYCPR------------------GTKY----CY---TQHRMD
Q66IA6_DANRE/40-145-TTPYPGGFKCFTCEDAPDN------YE--CNR.WAPDLYCPR------------------ESRY----CY---THHKMS
I3K1X6_ORENI/40-145-TTPYPGGFKCFTCQDAVDN------YD--CNR.WAPDVYCPK------------------DTKY----CS---TLHMMD
W5M046_LEPOC/2-106-.TPFPSSFKCFTCDRAADN------YD--CNR.WAEDKWCPQ------------------HTQY----CL---TVHHFG
E4X645_OIKDI/28-133-VLPYADAFRCFTCDNAVDN------YE--CNN.HAPDVFCPA------------------ETEF----CF---TEHVFK
H2LH52_ORYLA/38-143-TTPHPGGFKCFTCEDAPDN------YQ--CNR.WAPDVFCPK------------------GTKY----CY---TLHMMD
F1S0F8_PIG/49-153-QTKIFSGF.CFLNYNELGK------YS--CNE.SVRERKGGE------------------DTQY----CL---TVHHFT

PF01064

O16623_CAEEL/77-187--------VSCI.CNSDK........CN..DDSFTIPSDVVLTIPPVIKCFSQDLIEDNYCFGHY----CT---YEQEYI
O16623_CAEEL/298-408--------VSCF.CNTDK........CN..DDSFEIPTDVVLTVPPVMKCFEDDLNEDNYCYGHY----CI---YERDLT
ACV1C_RAT/26-100--------LKCV.CLL..........CD..SSN.....FTCQT...................EGA----CW---ASVMLT
Q9D7E5_MOUSE/28-111--------LRCYTCSFAK.......PCD..PVP.....RECRE...................DEV----CG---VSVGTS
Q7QGF7_ANOGA/72-163--------LTCY.CEGH.........CPGNLQN.....GTCETR.................PGGS----CF---VSVEAV
ACVR1_HUMAN/33-107--------YMCV.CEGLS........CG..NE......DHCE....................GQQ----CF---SSLSIN
BMPR2_MOUSE/32-131--------RLCAFKDPYQQD....LGIGESRISHENGTILCSK...................GST----CY---GLWEKS
O73801_TAKRU/34-111--------LRCN.CTN..........CE..KTG.....YECET...................DGA----CM---ASTYYV
BMR1B_HUMAN/30-110--------LRCK.CHHH.........CPEDSVN.....NICST...................DGY----CF---TMIEED
Q7Q709_ANOGA/56-159--------NGQEFVDDYDSYDDQPEPSD..EPVFEKNVSTVATCS...............RTAPF----CY---TLWTFD
TGFR1_RAT/30-108--------LQCF.CHL..........CT..KDN.....FTCET...................DGL----CF---VSVTET
A1Z7L9_DROME/127-204--------IKCH.CDT..........CK..ESN.....NICET...................DGF----CF---TSVEKN
A8NNV7_BRUMA/93-183--------..CY.CNYAPE......FCG.GFTN.....FTCIKH.................LEAS----CF---HFTEEI
F6SCX5_CIOIN/3-89--------LTCY.CGGSREN....PYCE..RNV.....FNCTV..................PEGV----CY---AMTEVL
F6VNM6_XENTR/11-99--------.ECIYYNANW.......ELE..KTNQS.GVESCEGEK...............DKRLH----CY---ASWRNN
K1QDS8_CRAGI/31-113--------LKCR.CSP..........CHPNAVN.....DTCIA...................KFQ----CF---TGLRLV
K1RCS7_CRAGI/7-89--------LKCY.CEE..........CT..DRN.....QTCET...................TGL----CL---TLRAYR
Q24468_DROME/35-126--------.ECEHFDEKM........CN..TT......QQCETRIEHC........KMEADKFPS----CY---VLWSVN
Q7QJY6_ANOGA/58-155--------YKCYSCEPPD........CA..DTAI..HAHYCQN...................AIQ----CW---KSRTR.
Q95SI0_DROME/15-104--------LTCY.CDGS.........CP..DNVS...NGTCETR.................PGGS----CF---SAVQQL

PF06211

Q9DFZ0_DANRE/1-107MDRLVSLWFQLELCAMAVLLTKGEIRCYCDAPHCVATGYMCKS------------------ELNA----CF---TKVLDP
BAMBI_HUMAN/4-111HSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMCKS------------------ELSA----CF---SRLLDP
Q6GQM7_DANRE/4-110NSSLVSIWLQLELCAMALLLTKGEIRCYCDAPHCVATGYMCKS------------------ELNA----CF---TRTLDP

PF08917

W5KF46_ASTMX/28-138--------NLCKWCDQSSPVCED.NICMSNCNFS----SFCML------------------TEEV----CV---AIWKKE
H3D8I2_TETNG/5-115--------KLCKFCDVRATSCTGIGSCTVGCEIT----STCAD------------------KEEV----CV---SIWRKA
W5PZA8_SHEEP/50-160--------QLCKFCDVRSSTCDNQKSCWSNCSIT----AICEK------------------PEEV----CV---AVWRKN
F6YQ99_ORNAN/145-254--------GLCKFCDVESTICTNQGVCKSNCSIT----SICEN------------------TFDI----CA---AVWRKN
H3A498_LATCH/46-156--------NLCLFCDLEPTNCEAQGSCKPTCNRT----SICED------------------PQEV----CI---AIWRKK
H3DPZ2_TETNG/1-112--------.LCRWCEASSPACLD.DVCFSNCSLS----SFCSL------------------AEEI----CI---AIWRKT
G3N4W2_GASAC/15-128--------NLCRWCEATGPLCRD.SVCFSNCSLS----SFCTA------------------TEEI----CV---AVWRKN
TGFR2_CHICK/39-148--------RLCKFCDVKATTCSNQDQCKSNCNIT----SICEK------------------NNEV----CA---AVWRRN
E7F998_DANRE/30-137--------RICSSCKPHPVNCVS.NQCFSNCSVS----TECVN------------------EQDV----CA---AVWWRD
TGFR2_RAT/49-159--------QLCKFCDVTLSTCDNQKSCMSNCSVT----SICEK------------------PQEV----CV---AVWRKN
U3KGG3_FICAL/28-138--------NLCKWCDSTAPACED.KVCYSNCNLN----SYCED------------------PYEI----CV---AIWRQD
H2MGM4_ORYLA/40-153--------NVCKWCLPSTPVCKD.NICLSNCNLS----SYCSF------------------TEEI----CI---AIWRKT
I3KGT1_ORENI/1-112--------.LCRWCEVSTPVCEG.NICSSNCNLT----SFCNT------------------TEEI----CI---AIWRKA
F6U8C1_XENTR/1-110--------.LCRFCDVKETTCENQGYCTSVCNIA----SVCEH------------------QEEV----CI---AIWRNK
W5M2T6_LEPOC/36-145--------LLCKFCDFEPSTCDGRSNCFSNCSKT----AICEK------------------PQEV----CV---SIWRKD
I3KUG9_ORENI/49-159--------KLCKFCDIQPTNCSGKGNCKVECGIT----SICPQ------------------KEDV----CV---SIWRKK
H3AP73_LATCH/29-139--------NLCKWCDESHPTCEN.NVCKSNCNFS----SFCET------------------AEEI----CV---TIWKEV
W5M4K1_LEPOC/30-140--------NFCKWCDSSSPRCEN.NVCTSNCNFS----SFCAM------------------SEEI----CV---AVWKQD
G3NFL8_GASAC/33-139--------MLCKFCDVRPTSCTGKGSCKVECEIT----AICPN------------------DEDV----CV---STWRKE
F1QAH4_DANRE/28-138--------NLCKWCDHSSPVCED.NVCMSNCSLT----SYCFL------------------AEEV----CV---AIWKKD

PF00021

LYNX1_MOUSE/59-129PISF..TDLPLVTK----MC---Y..SGC...........PD-------------------VSSLGLGPHVSI.......
LYPD3_RAT/142-224TAAN..VTVSLPVR----GC---VQDEAC...........TR-------------------DGVTGPGFTLSG.......
LY6D_HUMAN/23-93P.....LRGNLVKK----DC---A..ESC........TPSYT-------------------LQGQVSSGTSST.......
LY6A_MOUSE/29-105IVDS..QTRKVKNN----LC---L..PICP.......PNIES-------------------MEILGTKVNVKT.......
TX101_RAT/141-217SGGG..MDSVVHVK----GC---TTAIGC.........RLMA-------------------KMESVGPMTVKE.......
LYPD5_MOUSE/133-212NIGN..FSVPVYIR----TC---HR.PSC.........TTMG-------------------TTSPWTSIDLQG.......
Q63318_RAT/29-105VEGS..VRRTAKSN----LC---L..PICP.......KFPQR-------------------TEILGTVVYTKV.......
LY6C2_MOUSE/29-102IEDS..QRRKLKTR----QC---L..SFCP.......AGVP.-------------------..IKDPNIRERT.......
LY6G_MOUSE/6-82IVDS..HRSKVKSN----LC---L..PICP.......TTLDN-------------------TEITGNAVNVKT.......
LY6D_MOUSE/23-93P.....LNGNLVRK----EC---A..NSC........TSDYS-------------------QQGHVSSGSEVT.......
PSCA_HUMAN/23-93V.....GLLTVISK----GC---S..LNC...........VD-------------------DSQDYYVGKKNI.......
LYPD4_HUMAN/142-233QAGF..LNTTFLLM----GC---AREHNQ..........LLA-------------------DFHHIGSIKVTEVLNILEK
UPAR_HUMAN/216-294EPKN....QSYMVR----GC---ATASMCQ.......HAHLG-------------------DAFSMNHID..V.......
LY6E_MOUSE/23-99GFGN.VNLGYTLNK----GC---S..PIC.........PSEN-------------------VNLNLGVASVNS.......
LY6I_MOUSE/29-105IANS..QRKKVKSR----SC---H..PFCP.......DEIEK-------------------KFILDPNTKMNI.......
LY6F_MOUSE/29-105IVDS..QRRKVKNK----LC---F..PFCP.......ANLEN-------------------MEILGTTVNVNT.......
Q810N3_MOUSE/141-219HGGD..LSAIFSIS----GC---LNSSHT.........YLLN-------------------NQNTIGIISIKE.......
UPAR_RAT/27-101WEDA..EELEVVTR----GC---AHKEKT........NRTMS-------------------YRMGSVIVSLTE.......
UPAR_HUMAN/25-99WEEG..EELELVEK----SC---THSEKT........NRTLS-------------------YRTGLKITSLTE.......
LY6E_CHICK/23-96GIGG..KSGQSISK----GC---S..PVC...........PS-------------------AGINLGIAAASV.......
UPAR_BOVIN/211-289GLRN....PSYTIR----GC---AAPSWCQ.......SLHVA-------------------EAFDLTHVN..V.......
LYPD4_MOUSE/142-233QAGN..LNTTFLIM----GC---ARDSHK..........LLA-------------------DFQHIGSIRVTEVINVLDK
UPAR_RAT/216-295VLGN....RSYTVR----GC---ATASWCQ.......GSHVA-------------------DSFQ.THVNLSI.......
LY6H_HUMAN/28-111PSSS..RKDHSVNK----MC---A..SSCDFVKRHFFSDYLM-------------------GFINSGILKVDV.......
LY6E_HUMAN/23-99GIGNLVTFGHSLSK----TC---S..PAC.........PIPE-------------------.GVNVGVASMGI.......
G3HYY3_CRIGR/2-74WEDD..NELELEMR----DC---AHYEKT........NRTMS-------------------YRVNSKIISLAE.......
UPAR_BOVIN/23-97WEGG..NEMNVVRK----GC---THPDKT........NRSMS-------------------YRAADQIITLSE.......

PF00087

H9G4X1_ANOCA/21-96GVGN--SHKQSISK----GC---S--ATC---------PQGG-------------------IDLGVMAFSMK.-------
F6V970_CALJA/20-87PPD.--.HETIVIK----SC---A--YTC---------PGYQ-------------------ESLAASRAL...-------
C3XRB6_BRAFL/33-101VFT.--.ARSHVER----GC---A--STC---------SVTD-------------------NCKNIIGTGDCY-------
V8N389_OPHHA/3-65IFCG--SRGERLEF----GC---A--ATC---------PEVK-------------------PGVNIE......-------
V8N9N7_OPHHA/22-85GIP.--.FLPWVNR----GC---A--ATC---------PKPE-------------------PKVYVD......-------
V8N5J6_OPHHA/76-137KIS.--...NDRWY----GC---A--KTC---------TEQN-------------------TWRIYNK.....-------
H0XNS6_OTOGA/21-88PPG.--.HQTIVIK----SC---A--YTC---------PTLQ-------------------ESLPFSRAS...-------
V8N3G9_OPHHA/22-85VYPG--GYDH..TR----GC---A--ATC---------PKMK-------------------NHDTVH......-------
V8NAR0_OPHHA/17-92GSGE--YHKELISK----GC---S--ADC---------PEVG-------------------IDIGVMAFSMK.-------
G1U6Z7_RABIT/21-88PPG.--.QRTFVIK----SC---A--YTC---------PGYQ-------------------ESLAYSRAS...-------
V8N4I1_OPHHA/22-77HPV.--.....LLM----GC---T--YSC---------PTAK-------------------YSV.........-------
H0WCF0_CAVPO/21-88PPG.--.EKTIIIK----SC---A--YTC---------PGFQ-------------------ESLAASRAS...-------

PF02988

Q9PU34_9SAUR/20-103SSAP--ISFRTIHR----NC---FSSSLC------KLERFDI-------------------NIGHDSYLRGRI-------
Q9PTC5_PSETE/20-102IRAP--VSLSLISK----SC---GTSDTC------HLNYLET-------------------SPHNELTVKTKR-------
PLI_CRODU/20-102SSAS--LSVRTVHK----NC---FSSSIC------KLGQFDV-------------------NIGHHSYIRGRI-------
PLIB_ELAQU/20-102IRPP--LSITFTAK----TC---GTSDTC------HLDYVEA-------------------NPHTELTLRAKR-------
PLIA_ELAQU/20-103SSAP--LSIRSSHR----NC---FSSSLC------KLEHFDV-------------------NTGQETYLRGRI-------

PF16975

U3IGH3_ANAPL/42-147VTGE----SVSVTK----RC---VPLEDC------L..STGC..-----------------TYVKHEEYKVCT-------
F7E963_XENTR/52-157SQGK----STSVTK----KC---ATREEC------H..AVGC..-----------------HHRLDSGHMECV-------
U3KHG3_FICAL/185-290ARGQ----STSVTK----KC---ATGEEC------H..LVGC..-----------------HRHGDSGHTERV-------
LPD6B_MOUSE/58-163SHGR----STSITK----KC---ASKNEC------H..FVGC..-----------------RHSRDSEHTECR-------
F7GBQ8_MONDO/39-144SHGS----STSITK----KC---ASKSEC------H..FVGC..-----------------HHHQDGGQTECR-------
M3XHD6_LATCH/2-108SHGK----SKSVTK----RC---AKKEEC------H..FVGCHH-----------------HHHRDFGHTECT-------
F7CHM5_ORNAN/40-144ASGN----SVSVTK----RC---VALEDC------L..STGC..-----------------VDLEVEGHKVSS-------
F1R757_DANRE/34-138HHGK----TKFVTK----RC---AVRDEC------R..LAGC..-----------------RHHKNT.HHECV-------
F7FWP8_MACMU/40-145VTGN----SISVTK----RC---VPLEEC------L..STGC..-----------------RDSEHEGHKVCT-------
A8WGG8_XENTR/40-145ATGE----SVSVTK----RC---AALEHC------L..NSGC..-----------------RDSINKDQKVCT-------
R4GHW2_CHICK/40-145DHGK----STSVTK----KC---ATGDEC------H..FVGC..-----------------HHHRESGHTECV-------
M4A0F0_XIPMA/40-140NHGD----SVSVTK----RC---ATLEHC------R..FAGC..-----------------VNITHNGFQVCT-------
H9G7P9_ANOCA/40-145ANGK----SVSVTK----RC---VPLEDC------L..ATGC..-----------------IDLQHKGLRVCT-------
H9G7N5_ANOCA/44-149SHGR----STSVTK----KC---ATREEC------H..FVGC..-----------------RHRKETSHTECI-------
H3AJQ0_LATCH/40-145SNGM----SISVTK----QC---MSLEGC------M..STGC..-----------------SETKLEGHKVCT-------
Q66IA6_DANRE/40-145WDGN----TVSVTK----RC---VPLEDC------L..QTGC..-----------------SDIDHEGNRVCT-------
I3K1X6_ORENI/40-145RSGE----SVSVTK----RC---ATMEEC------L..FTGC..-----------------ADVADTGYQVCS-------
W5M046_LEPOC/2-106SRGR----SRWVTK----KC---AAREEC------Q..AVGC..-----------------RHHTSTGHTECV-------
E4X645_OIKDI/28-133EETD----SIRVRK----SC---MTRNKC------HEQELGC..-----------------QTDPISGHTTCK-------
H2LH52_ORYLA/38-143DNGS----SVSVTK----RC---ATLENC------Q..LTGC..-----------------VNVTRTGYQMCT-------
F1S0F8_PIG/49-153SHGR----STFITK----KC---ASRSEC------H..FVGC..-----------------HHSQDSEHTECR-------

PF01064

O16623_CAEEL/77-187RNDF--GDAYTSINSPSRGC---SDLEYA---EDLNS.PNMCRL..................L.....NGLLE-------
O16623_CAEEL/298-408RNEF--GDVFPRTAKPRRGC---SDPNYT---QDLSR.KNMCKI..................E.....NDWLQ-------
ACV1C_RAT/26-100NG..--..KEQVSK....SC---VSLPEL---NAQ....VFCHS..................SNN...VTKTE-------
Q9D7E5_MOUSE/28-111EQKE--..EEVIER...KGC---LPRAQC---PLLGHATYWSRS.................Y......SLRHQ-------
Q7QGF7_ANOGA/72-163LDEE--..TKQLVPEYSHGC---MSPEQG---GGL....LQCKV................GTVSPQLHGKSIV-------
ACVR1_HUMAN/33-107DG..--..FHVYQK....GC---FQVYEQ---GK.....MTCKT.................PPSP...GQAVE-------
BMPR2_MOUSE/32-131KGD.--..INLVKQ....GC---WSHIGD---PQECH.YEECVVT...............TTPPSIQNGTYRF-------
O73801_TAKRU/34-111ER..--..KEQHIR....IC---INRDSL---VPPGQ.PFYCLS..................AEG...LLNTH-------
BMR1B_HUMAN/30-110DSG.--..LPVVTS....GC---LGLEGS---D......FQCRD..................TPIPHQRRSIE-------
Q7Q709_ANOGA/56-159I...--..VKNVTRVVVQGC---WGSNDD---QESCS.SNECVS...................TTETPTRHFF-------
TGFR1_RAT/30-108TD..--..KVIHNS....MC---IAEIDL---IPRDR.PFVCAP.................SSKT...GAVTY-------
A1Z7L9_DROME/127-204SDG.--..SIIFSY....SC---MVVKYN---MQRSK.PFECLT.................SNERF.DTYRID-------
A8NNV7_BRUMA/93-183YDKT--..LKQIETMHLFGC---APLTRG---SGGSY..FTCKA.................HLVAHARPKSIA-------
F6SCX5_CIOIN/3-89PISK--..NILTQR....GC---FRKNRL---VPYNR.PFVCEP.................VNKS...NHQVI-------
F6VNM6_XENTR/11-99SG.F--..IELVKK....GC---WLDDFN---CY.DR..QECIA.................KEEN...PQVFF-------
K1QDS8_CRAGI/31-113VENG--EQVEIISK....GC---MSEEEN---SI.....LQCKG.................HLVPHRLPRTVE-------
K1RCS7_CRAGI/7-89KD.G--..TIKIRY....RC---IEKVDL---GPLDGDVFECLT..................SNPMASISSKL-------
Q24468_DROME/35-126ETTG--..ILRIKM...KGC---FTDMHE---CNQ....TECVT.................SAEPR.QGNIHF-------
Q7QJY6_ANOGA/58-155DPEG--..NENVQR....GC---TTEHEQ---LP.....LYCSQNQKPNTGDSGGPKKRHVSSTG...MYNIE-------
Q95SI0_DROME/15-104YDET--..TGMYEEERTYGC---MPPEDN---GGF....LMCKV.................AAVPHLHGKNIV-------

PF06211

Q9DFZ0_DANRE/1-107LNTN-----SPLTH----GC---VDSLLN--------SADVCSSKN---------------VDISSGSSSP.V-------
BAMBI_HUMAN/4-111QNSN-----SPLTH----GC---LDSLAS--------TTDICQAKQ---------------ARNHSGTTIPTL-------
Q6GQM7_DANRE/4-110QSTN-----SPLSH----GC---YDPMLN--------SGKTCHSES---------------TFDRIHGSAT.L-------

PF08917

W5KF46_ASTMX/28-138NESVSVQTMCHNPQHALENI...VLSNHS---------STECVM-----------------TPLPSENGMLFL-------
H3D8I2_TETNG/5-115GSNVTFDTVCHNPAYKLYGL...VLDDYN---------NSKCEM-----------------KEIKGMGSKFFI-------
W5PZA8_SHEEP/50-160DENITLETVCHDPKIAYHGF...VLDDAA---------SPKCIM-----------------KERKGSGETFFM-------
F6YQ99_ORNAN/145-254DENITLETICHDQRLPLHGF...DLDDIG---------SSKCMM-----------------KEKKMLGETMFM-------
H3A498_LATCH/46-156GTNVTIETVCHDPKKKLHGF...DIEDFE---------SNTCEM-----------------KEKKVPDWQVYM-------
H3DPZ2_TETNG/1-112NETTTVHTTCHNPALPLEGISPALLLNFT---------SRECHM-----------------TSQPAEGATLMV-------
G3N4W2_GASAC/15-128NDTMTVHTMCHNPTLPLEGVDPELLLNFT---------TAECHM-----------------VPQPAEDGDLMV-------
TGFR2_CHICK/39-148DENVTLETICHDPQKRLYGH...MLDDSS---------SEQCVM-----------------KEKKDDGGLMFM-------
E7F998_DANRE/30-137AGLVMVETLCHDPLKPMLGV...MVEDIL---------ISECVL-----------------QEQNIHGRHLRV-------
TGFR2_RAT/49-159DKNITLETVCHDPKFTYHGF...TLEDAT---------SPTCVM-----------------KEKKRAGETFFM-------
U3KGG3_FICAL/28-138NESIRISTLCHNPQRPIENL...MVPNYN---------TSRCTM-----------------SQQPSQDGLVYI-------
H2MGM4_ORYLA/40-153NETMTVHTMCHHPNLPLEGINPRLLLNFT---------SRECHM-----------------LPQPADEGVMMV-------
I3KGT1_ORENI/1-112NNTMTVYTMCHHPNLPLDGISPDLLRTFT---------SRECRM-----------------VPQAANDS.MMV-------
F6U8C1_XENTR/1-110DGNITEETMCHDPKKELYGY...KLDDYN---------EKECIM-----------------KEKKTSEGIMSM-------
W5M2T6_LEPOC/36-145DNNVTIETLCHDPAEKIYGL...LLDDYN---------STKCYM-----------------KEKKFPGSLFYV-------
I3KUG9_ORENI/49-159DGNVTFDTVCHNPAEKLYGL...VLKDYN---------NSECEM-----------------KELSGMGSKFFI-------
H3AP73_LATCH/29-139NGSTSVRTLCHHPRVLVENV...FVPHYN---------TNECLM-----------------TKQSTEEGLLYI-------
W5M4K1_LEPOC/30-140NESVSVRTLCHHPQETLENI...MVSNYS---------TTQCVM-----------------VQQSSDEGTVYI-------
G3NFL8_GASAC/33-139GDNFTIDTVCHNRFHKLHGL...ALEDYN---------NSKCEM-----------------KERKGMGSQFFI-------
F1QAH4_DANRE/28-138NVSVSVRTLCYDPQHMLENI...MLANYS---------SKECLM-----------------SPHPSEDGLLFI-------

PF00021

LYNX1_MOUSE/59-129....AC.CQSN-LCN--------------------
LYPD3_RAT/142-224....SC.CQGP-RCN--------------------
LY6D_HUMAN/23-93....QC.CQED-LCN--------------------
LY6A_MOUSE/29-105....SC.CQED-LCN--------------------
TX101_RAT/141-217....TC.SYQS-FLH--------------------
LYPD5_MOUSE/133-212....YC.CEGH-LCN--------------------
Q63318_RAT/29-105....SC.CNTD-LCN--------------------
LY6C2_MOUSE/29-102....SC.CSED-LCN--------------------
LY6G_MOUSE/6-82....YC.CKED-LCN--------------------
LY6D_MOUSE/23-93....QC.CQTD-LCN--------------------
PSCA_HUMAN/23-93....TC.CDTD-LCN--------------------
LYPD4_HUMAN/142-233SQIVGAASSRQ-DPA--------------------
UPAR_HUMAN/216-294....SC.CTKS-GCN--------------------
LY6E_MOUSE/23-99....YC.CQSS-FCN--------------------
LY6I_MOUSE/29-105....SC.CQED-LCN--------------------
LY6F_MOUSE/29-105....SC.CKED-LCN--------------------
Q810N3_MOUSE/141-219....TLESNVT-LSS--------------------
UPAR_RAT/27-101....TV.CATN-LCN--------------------
UPAR_HUMAN/25-99....VV.CGLD-LCN--------------------
LY6E_CHICK/23-96....YC.CDSF-LCN--------------------
UPAR_BOVIN/211-289....SC.CTGS-GCN--------------------
LYPD4_MOUSE/142-233SEAVSAGHCSQ-GIS--------------------
UPAR_RAT/216-295....SC.CNGS-GCN--------------------
LY6H_HUMAN/28-111....DC.CEKD-LCN--------------------
LY6E_HUMAN/23-99....SC.CQSF-LCN--------------------
G3HYY3_CRIGR/2-74....VV.CATD-VCN--------------------
UPAR_BOVIN/23-97....TV.CRSD-LCN--------------------

PF00087

H9G4X1_ANOCA/21-96----.C-CESS-LCN--------------------
F6V970_CALJA/20-87----.C-CNTD-LCN--------------------
C3XRB6_BRAFL/33-101----RC-CETD-NCN--------------------
V8N389_OPHHA/3-65----.C-CSTD-NCN--------------------
V8N9N7_OPHHA/22-85----.C-CARD-KCN--------------------
V8N5J6_OPHHA/76-137----.C-CTTN-LCN--------------------
H0XNS6_OTOGA/21-88----.C-CNTD-LCN--------------------
V8N3G9_OPHHA/22-85----.C-CTTD-KCN--------------------
V8NAR0_OPHHA/17-92----.C-CENS-FCN--------------------
G1U6Z7_RABIT/21-88----.C-CNTD-LCN--------------------
V8N4I1_OPHHA/22-77----.C-CSTD-KCN--------------------
H0WCF0_CAVPO/21-88----.C-CNTD-LCN--------------------

PF02988

Q9PU34_9SAUR/20-103----HC-CDEA-RCEA-------------------
Q9PTC5_PSETE/20-102----TC-CTGE-ECKT-------------------
PLI_CRODU/20-102----NC-CEKE-LCED-------------------
PLIB_ELAQU/20-102----AC-CTGD-ECQT-------------------
PLIA_ELAQU/20-103----HC-CDEK-KCEG-------------------

PF16975

U3IGH3_ANAPL/42-147----SC-CEGS-ICNLPLPRNTTDAV...FTTLSP
F7E963_XENTR/52-157----SC-CDGM-ICNVEVPTNHTNAV...FSVMKS
U3KHG3_FICAL/185-290----SC-CEGM-ICNVQIPTNATNAV...LAVLQA
LPD6B_MOUSE/58-163----SC-CEGM-ICNVELPTNHTNAV...FAVMHA
F7GBQ8_MONDO/39-144----SC-CEGM-ICNVEVPTNNTNAV...FAVIQA
M3XHD6_LATCH/2-108----SC-CEGM-ICNVDVPTNHTNAV...FAVIQS
F7CHM5_ORNAN/40-144----SA-LXGN-ICNC....DASQRVGRHFATTSP
F1R757_DANRE/34-138----SC-CEGM-VCNVELPTNHSNAV...FAQRRA
F7FWP8_MACMU/40-145----SC-CEGN-ICNLPLPRNETDAT...FATTSP
A8WGG8_XENTR/40-145----SC-CEGN-ICNLPLPRNETDAI...FATTSP
R4GHW2_CHICK/40-145----SC-CEGM-ICNVEIPTNHTNAV...FAVLHA
M4A0F0_XIPMA/40-140----SC-CHGN-ICNVLVPRNDSGAV...FSSAGP
H9G7P9_ANOCA/40-145----SC-CEGN-ICNLPLPRNASDAI...FATTTP
H9G7N5_ANOCA/44-149----SC-CEGM-ICNVDIPTNQTNAV...FAVVHT
H3AJQ0_LATCH/40-145----SC-CEGN-ICNLPLPWNASDAI...FATISP
Q66IA6_DANRE/40-145----AC-CEGN-ICNLPLPRNETDAI...FSTTSP
I3K1X6_ORENI/40-145----SC-CEGN-ICNVLVPRNDSSAI...FSSISP
W5M046_LEPOC/2-106----SC-CEGM-ACNVEVPTNRTNAV...FAMMKS
E4X645_OIKDI/28-133----EC-CQGE-ICNLPVPKTNER.....FEEMLA
H2LH52_ORYLA/38-143----SC-CEGN-ICNIMVPRNDSSAI...FSSTSP
F1S0F8_PIG/49-153----SC-CEGM-ICNVELPTNNTNAV...FAVMHA

PF01064

O16623_CAEEL/77-187----CQ-CSTP-YCNRDQPFEV-------------
O16623_CAEEL/298-408----CI-CDTE-FCNREQNIEV-------------
ACV1C_RAT/26-100----CC-F.TD-FCNNITQHLP-------------
Q9D7E5_MOUSE/28-111----CC-E.QD-LCNAAASQPP-------------
Q7QGF7_ANOGA/72-163----CC-DNED-LCNQDLQPPY-------------
ACVR1_HUMAN/33-107----CC-Q.GD-WCNRNITAQL-------------
BMPR2_MOUSE/32-131----CC-CSTD-LCNVNFTENF-------------
O73801_TAKRU/34-111----CC-Y.ED-YCNSIDLKVP-------------
BMR1B_HUMAN/30-110----CC-TERN-ECNKDLHPTL-------------
Q7Q709_ANOGA/56-159----CC-CSGD-NCNGNFSYLP-------------
TGFR1_RAT/30-108----CC-N.QD-HCNKIELPTT-------------
A1Z7L9_DROME/127-204----CC-K.SD-FCNKNE....-------------
A8NNV7_BRUMA/93-183----CC-QEGN-YCNRNLSV..-------------
F6SCX5_CIOIN/3-89----CC-K.TD-FCNHPEAME.-------------
F6VNM6_XENTR/11-99----CC-CEGN-YCNKKFTHL.-------------
K1QDS8_CRAGI/31-113----CC-NDED-YCNDFLDP..-------------
K1RCS7_CRAGI/7-89----CC-NDED-FCNKHLFPT.-------------
Q24468_DROME/35-126----CC-CKGS-RCNSNQKY..-------------
Q7QJY6_ANOGA/58-155----CC-T.GD-YCNNGSFPE.-------------
Q95SI0_DROME/15-104----CC-DKED-FCNRDLYPT.-------------

PF06211

Q9DFZ0_DANRE/1-107----EC-CHDD-MCNYRGLHD--------------
BAMBI_HUMAN/4-111----EC-CHED-MCNYRGLHD--------------
Q6GQM7_DANRE/4-110----QC-CHED-MCNYRGLQD--------------

PF08917

W5KF46_ASTMX/28-138----CS-CVREHDCNDRLIFDKGPHGFSRL-----
H3D8I2_TETNG/5-115----CS-CSTD.ECNEHIFFNPSPLATNSE-----
W5PZA8_SHEEP/50-160----CS-CSAE.ECNDHIIFSEEYTSSNPD-----
F6YQ99_ORNAN/145-254----CS-CSSE.ECNDLLYFSEE.VAANPE-----
H3A498_LATCH/46-156----CA-CLGE.ECNGDLIFTKIHGTSPEN-----
H3DPZ2_TETNG/1-112----CG-CRGEHECNDKLIFDQGAS.FSKL-----
G3N4W2_GASAC/15-128----CG-CDGEQECNDKLIFDKGANGFSKV-----
TGFR2_CHICK/39-148----CS-CTGE.ECNDVLIFSAI.DPHKPE-----
E7F998_DANRE/30-137----CS-CTGD.QCNQNLLLRKLTEEEK..-----
TGFR2_RAT/49-159----CS-CNTE.ECNDYIIFNEEYTTSSPD-----
U3KGG3_FICAL/28-138----CG-CVDEQECNDKLIFENHTNGYSML-----
H2MGM4_ORYLA/40-153----CG-CQGEQECNDKLIFDKGVSGFSRL-----
I3KGT1_ORENI/1-112----CG-CQGEHECNDKLVFDKGANGFLPL-----
F6U8C1_XENTR/1-110----CS-CRGK.LCTERFYFPPANETNIDP-----
W5M2T6_LEPOC/36-145----CS-CTEE.ECNNKLIFSPEVEPPTP.-----
I3KUG9_ORENI/49-159----CS-CSED.ECNERVFFDPTLGPTEPQ-----
H3AP73_LATCH/29-139----CG-CVEEHECNDKIIFEPERNGSTIL-----
W5M4K1_LEPOC/30-140----CG-CVEDHECNDMLVFDKHSNGYLKL-----
G3NFL8_GASAC/33-139----CS-CSED.ECNEHVFFN....SYSPH-----
F1QAH4_DANRE/28-138----CS-CVGDQECNDRLIFDKGPNGFSKL-----

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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