Sequence alignment for CL0117

PF00021

LYPD3_RAT/142-224--------------------------CYSCMGL.--------SREKCQGAMPPVVNCY-NA------------------S
CD59_CHLAE/28-95--------------------------CYNCPNP.--------.TTDCKTA....INCS-SG------------------F
CD59_RAT/25-92--------------------------CYNCLDP.--------.VSSCKTN....STCS-PN------------------L
Q9R119_CRIGR/210-288--------------------------CYSCEGN.--------STHGCSSKETSLVDCR-GP------------------M
LY6D_HUMAN/23-93--------------------------CHVCT...--------SSSNCKHS....VVCP-AS------------------S
LY6A_MOUSE/29-105--------------------------CYQCYGVP--------FETSCPSI.....TCP-YP------------------D
CD59_RABIT/28-95--------------------------CYHCLLP.--------.SPNCSTV....TNCT-PN------------------H
TX101_RAT/141-217--------------------------CPTCL...--------ALEPCSSA..PSMPCA-NG------------------T
LYPD5_MOUSE/133-212--------------------------CYACLGT.--------HPEDCSPEKSRRVQCH-QD------------------Q
Q63318_RAT/29-105--------------------------CYSCIEVP--------LNANCSTA.....TCP-YS------------------D
CD59_HUMAN/28-95--------------------------CYNCPNP.--------.TADCKTA....VNCS-SD------------------F
LY6C2_MOUSE/29-102--------------------------CYECYGVP--------IETSCPAV.....TCR-AS------------------D
LY6G_MOUSE/6-82--------------------------CYNCIGVP--------PETSCNTT.....TCP-FS------------------D
TX101_CRIGR/143-219--------------------------CPTCV...--------ALGSCSSA..PSMPCA-NS------------------T
LY6D_MOUSE/23-93--------------------------CHVCT...--------NSANCKNP....QVCP-SN------------------F
PSCA_HUMAN/23-93--------------------------CYSCKAQV--------SNEDCLQV....ENCT-QL------------------G
LYPD4_HUMAN/142-233--------------------------CPTCVGE.--------HMKDCLPNFVTTNSCP-LA------------------A
UPAR_HUMAN/216-294--------------------------CYSCKGN.--------STHGCSSEETFLIDCR-GP------------------M
LY6E_MOUSE/23-99--------------------------CFSCTDQK--------NNINCLWP....VSCQ-EK------------------D
LY6I_MOUSE/29-105--------------------------CYQCYGVP--------FETSCPSF.....TCP-YP------------------D
LYNX1_MOUSE/23-92--------------------------CHVCAY..--------NGDNCFKP....MRCP-AM------------------A
TX101_MOUSE/141-217--------------------------CPTCV...--------ALGSCSSA..PSMPCA-NG------------------T
LY6F_MOUSE/29-105--------------------------CYNCLGVS--------LGIACKSI.....TCP-YP------------------D
Q810N3_MOUSE/141-219--------------------------CPVCLD..--------FKGSCNTE.SNHTLCP-KD------------------T
UPAR_RAT/27-101--------------------------CIQCE...--------SNQDCLVE.....ECA-LG------------------Q
CD59_PIG/28-96--------------------------CYNCINP.--------.AGSCTTA....MNCS-HN------------------Q
UPAR_HUMAN/25-99--------------------------CMQCK...--------TNGDCRVE.....ECA-LG------------------Q
CD59_SHV21/22-89--------------------------CYNCSHS.--------.TMQCTTS....TSCT-SN------------------L
Q9TVA9_BOVIN/1-75--------------------------CLQCE...--------NTTSCSVE.....ECT-PG------------------Q
LY6E_CHICK/23-96--------------------------CFSCSDAS--------SNWACLTP....VKCA-EN------------------E
UPAR_BOVIN/211-289--------------------------CYSCEGN.--------GAHRCSSEETFLIDCR-GP------------------M
LYPD4_MOUSE/142-233--------------------------CPSCVGK.--------HDQECLPSFVTTENCP-FA------------------A
UPAR_RAT/216-295--------------------------CYSCEGN.--------STFGCSYEETSLIDCR-GP------------------M
Q9R119_CRIGR/21-95--------------------------CMQCE...--------DSQNCLVK.....ECA-LG------------------Q
LY6H_HUMAN/28-111--------------------------CQDCTLTT--------NSSHCTPK.....QCQ-PS------------------D
CD59A_MOUSE/26-94--------------------------CYHCFQP.--------VVSSCNMN....STCS-PD------------------Q
LY6E_HUMAN/23-99--------------------------CFSCLNQK--------SNLYCLKP....TICS-DQ------------------D
Q63316_RAT/5-82--------------------------CYNCTMIP--------FGNTCSST....ATCP-YP------------------D
CD59_AOTTR/28-95--------------------------CYSCPYP.--------.TTQCTMT....TNCT-SN------------------L
LYPD5_HUMAN/135-214--------------------------CYACIGV.--------HQDDCAIGRSRRVQCH-QD------------------Q

PF02988

Q9PU34_9SAUR/20-103------------------------HSCEICHN----------FGKDCQSE--EAKECA-SP------------------E
Q9PTC5_PSETE/20-102------------------------LECDICIG----------LGRECNT.--WTKTCD-AN------------------Q
PA2I_CRODU/20-102------------------------RSCDFCHN----------IGKDCDG.--YEEECS-SP------------------E
PLIGB_ELAQU/20-102------------------------IDCEHCVV----------WGQNCTG.--WKETCG-EN------------------E
PLIGA_ELAQU/20-103------------------------RSCEICHN----------VGNDCGYD--YVEECH-SP------------------E

PF00087

NXLH_PSEAU/22-85------------------------LTCYKG------------RD.R..SS----ETCR.SE------------------Q
NXL1_NOTSC/22-84------------------------LICYMG------------P..K..TP----RTCP.RG------------------Q
TXW1_OPHHA/22-82------------------------LICFNQ------------ETYRPETT----TTCP.DG------------------E
NXS1_BOUCH/1-61------------------------MECHNQ------------QSSQPPTT----THCS.GG------------------E
CX1_NAJMO/1-60------------------------LKCNQL------------IP.P..FW----KTCP.KG------------------K
NXLH_BUNMU/25-87------------------------KICHFD------------TC.RAGEL----KVCA.SG------------------E
NXS2_NAJHA/1-60------------------------MICHNQ------------QSSQPPTI----KTCP.GE------------------T
TX510_DENJA/1-57------------------------RICYNH------------QSNTPATT----KSC...V------------------E
NXL1_ACAAN/1-63------------------------VICYRG------------Y..N..NP----QTCP.PG------------------E
NXS1_BUNFA/1-63------------------------RICLNQ------------QQ.S..TP----EDQPTNG------------------Q
NXS1_BOUAN/1-60------------------------KICYNQ------------PSSQHPTT----KACP.GE------------------K
TXW1C_HEMHA/1-60------------------------FTCFTT------------PS.D..TS----ETCP.IG------------------N
NXLB_PSETE/1-65------------------------RTCFIT------------PD.V..KS----KPCP.PG------------------Q
NXLB1_BUNMU/22-86------------------------KTCLKT------------PS.S..TP----QTCP.QG------------------Q
NXS3_NAJMO/1-61------------------------LNCHNQ------------MSAQPPTT----TRCS.RW------------------E
NXL2_BUNFL/1-65------------------------RTCLIS------------PS.S..TS----QTCP.KG------------------Q
TXW9A_NAJKA/1-63------------------------LTCLNC------------PEMFCGKF----QICR.NG------------------E
NXS3_NAJHA/1-60------------------------MICYKQ------------QSLQFPIT----TVCP.GE------------------K
NXL1_NAJME/1-64------------------------KRCYRT------------PD.L..KS----QTCP.PG------------------E
NXS1_DENJA/1-59------------------------RICYNH------------QSTTPATT----KSC...G------------------E
CX10_NAJHA/1-60------------------------LECNQL------------IP.I..AH----KTCP.EG------------------K
NXL1_LATSE/22-84------------------------RECYLN------------P..H..DT----QTCP.SG------------------Q
TX496_DENVI/1-59------------------------MICYSH------------KTPQNSAT----ITC...E------------------E
TXM2_DENAN/22-85------------------------LTCVTT------------KSIGGVTT----EDCP.AG------------------Q
NXL1_NAJOX/1-65------------------------ITCYKT------------P..IPITS----ETCA.PG------------------Q
NXL1_DENJA/1-64------------------------RTCYKT------------YS.D..KS----KTCP.RG------------------E
CX2_NAJME/1-61------------------------IKCHNT------------L..LPFIY----KTCP.EG------------------Q
NXSC_LATSE/22-82------------------------RICFNH------------QSSQPQTT----KTCS.PG------------------E
CX11_NAJHH/1-62------------------------LKCHNT------------Q..LPFIY----KTCP.EG------------------K
TX022_DENAN/1-59------------------------RICYSH------------KASLPRAT----KTC...V------------------E
TXW2_NAJHH/1-60------------------------FTCFTT------------PS.D..TS----ETCP.DG------------------Q
TX311_DENAN/22-80------------------------RICYSH------------KLLQAKTT----KTC...E------------------E
NXL1V_BUNMU/22-87------------------------IVCHTT------------AT.SPISA----VTCP.PG------------------E
CXH_HEMHA/1-62------------------------LICHNR------------P..LPFLH----KTCP.EG------------------Q
NXL4_OPHHA/1-65------------------------TKCYKT------------GDRI..IS----EACP.PG------------------Q
NXL1_NAJHC/1-64------------------------IRCFIT------------PD.V..TS----QACP.DG------------------Q
TX48_DENJA/1-59------------------------RICYTH------------KSLQAKTT----KSC..EG------------------.
TXW5_NAJNA/1-61------------------------LTCLIC------------PEKYCNKV----HTCL.NG------------------E
NXL1_ASTST/1-63------------------------LSCYLG------------Y..K..HS----QTCP.PG------------------E
TSYL3_DENPO/1-64------------------------LTCVTS------------KSIFGITT----EDCP.DG------------------Q
CXH48_ASPSC/1-63------------------------RKCFNS------------PGRL..VS----KPCP.EG------------------N
CX1_HEMHA/1-61------------------------LKCHNK------------L..VPFLS----KTCP.EG------------------K
NXL1_ASPSC/1-63------------------------RICYIA------------P..Y..DH----KTCA.AG------------------E
TXAC_DENPO/1-60------------------------TICYSH------------TTTSRAIL----KDC...G------------------E
TXW11_NAJHH/1-64------------------------LTCLIC------------PEKYCNKV----HTCR.NG------------------E
CXH32_ASPSC/1-62------------------------RKCLNT------------P..LPLFY----KTCP.EG------------------K
NXS1_ACAAN/1-61------------------------MQCCNQ------------QSSQPKTT----TTCP.GG------------------V
TXW10_NAJNI/1-64------------------------LRCLNC------------PEVFCRNF----HTCR.NG------------------E

PF06211

Q9DFZ0_DANRE/1-107MDRLVSLWFQLELCAMAVLLTKGEIRCY-CDAPH--------CV--ATG-----YMCK-SE------------------L
BAMBI_HUMAN/4-111HSSYIFIWLQLELCAMAVLLTKGEIRCY-CDAAH--------CV--ATG-----YMCK-SE------------------L
Q68F57_XENLA/4-112QASLISLWLQLELWAMAALLSKGEIRCY-CDAPQ--------CV--ATG-----YMCK-SE------------------L
Q6GQM7_DANRE/4-110NSSLVSIWLQLELCAMALLLTKGEIRCY-CDAPH--------CV--ATG-----YMCK-SE------------------L

PF01064

O16623_CAEEL/77-187------------------------VSCI.CNSDK........CN..DDSFTIPSDVVL-TIPPVIKCFSQDLIEDNYCFG
O16623_CAEEL/298-408------------------------VSCF.CNTDK........CN..DDSFEIPTDVVL-TVPPVMKCFEDDLNEDNYCYG
ACV1C_RAT/26-100------------------------LKCV.CLL..........CD..SSN.....FTCQ-T...................E
Q24229_DROME/34-128------------------------IECEHFDEKM........CN.TTQQCETRIEHCK-MEA...............DKF
O73736_DANRE/26-99------------------------IDCM.CVGSD........CN..E.......QQCT-....................G
Q6PUB8_ANOGA/12-110------------------------YKCYSCEPPD........CA..DTAI..HAHYCQ-N...................A
Q95UF3_ANCCA/52-144------------------------NLCF.CNYEGD......ICD..AN......NTCM-KH.................SH
Q9D7E5_MOUSE/28-111------------------------LRCYTCSFAK.......PCD..PVP.....RECR-E...................D
Q8MPR1_CRAGI/23-106------------------------LKCY.CEE..........CT..DRN.....QTCE-T...................T
Q7QGF7_ANOGA/72-163------------------------LTCY.CEGH.........CPGNLQN.....GTCE-TR.................PG
O42338_XENLA/57-136------------------------LNCY.CSGY.........CPQNAVN.....NTCI-T...................N
Q91595_XENLA/28-108------------------------LKCH.CET..........CV..KEN.....HTCI-T...................D
Q86SD0_CIOIN/20-107------------------------LTCY.CGGSREN....PYCE..RNV.....FNCT-V..................PE
ACVL1_RAT/33-104------------------------VNCT.CENPH........CK..R.......PICQ-....................G
ACVR1_HUMAN/33-107------------------------YMCV.CEGLS........CG..NE......DHCE-....................G
BMPR2_MOUSE/32-131------------------------RLCAFKDPYQQD....LGIGESRISHENGTILCS-K...................G
O73801_TAKRU/34-111------------------------LRCN.CTN..........CE..KTG.....YECE-T...................D
Q7YXA1_CRAGI/31-115------------------------LKCR.CSP..........CHPNAVN.....DICI-A...................K
BMR1B_HUMAN/30-110------------------------LRCK.CHHH.........CPEDSVN.....NICS-T...................D
Q6DEV8_XENTR/28-118------------------------RECIYYNANW........EL..EKTNQSGVESCE-GEK...............DKR
Q23975_DROME/127-208------------------------IKCH.CDT..........CK..ESN.....NICE-T...................D
Q7Q709_ANOGA/56-159------------------------NGQEFVDDYDSYDDQPEPSD..EPVFEKNVSTVA-TCS...............RTA
O16149_BRUPA/78-172------------------------SFCY.CNYAPE......FCGGFKN......FTCI-KH.................LE
TGFR1_RAT/30-108------------------------LQCF.CHL..........CT..KDN.....FTCE-T...................D
Q24326_DROME/69-159------------------------LTCY.CDGS.........CPDNVSN.....GTCE-TR.................PG
Q5R5N7_PONAB/32-109------------------------LLCA.CTS..........CL..QAN.....YTCE-T...................D

PF00021

LYPD3_RAT/142-224GRVYKGCFDG------NVTLTAAN..VTVSL-PVR----GCVQDEAC...........T---------------RDGVTG
CD59_CHLAE/28-95DT....CLIA------RA..........GLQ-VYN----QCWKFANC.........NFN---------------DISTLL
CD59_RAT/25-92DA....CLVA------VS..........GKQ-VYQ----QCWRFSDC.........NAK---------------FILSRL
Q9R119_CRIGR/210-288DQ....CLEA------TGLDVLAN....RSH-TVR----GCSTASWC.......PGSHV---------------ADAFLL
LY6D_HUMAN/23-93RF....CKTT------NTVEP.....LRGNL-VKK----DCA..ESC........TPSY---------------TLQGQV
LY6A_MOUSE/29-105GV....CVTQ------EAAVIVDS..QTRKV-KNN----LCL..PIC.......PPNIE---------------SMEILG
CD59_RABIT/28-95DA....CLTA------VS..........GPR-VYR----QCWRYEDC.........NFE---------------FISNRL
TX101_RAT/141-217TQ....CYHG------KIELSGGG..MDSVV-HVK----GCTTAIGC.........RLM---------------AKMESV
LYPD5_MOUSE/133-212SA....CFQG------NGRMNIGN..FSVPV-YIR----TCHR.PSC.........TTM---------------GTTSPW
Q63318_RAT/29-105GV....CVSQ------VLEAVEGS..VRRTA-KSN----LCL..PIC.......PKFPQ---------------RTEILG
CD59_HUMAN/28-95DA....CLIT------KA..........GLQ-VYN----KCWKFEHC.........NFN---------------DVTTRL
LY6C2_MOUSE/29-102GF....CIAQ------NIELIEDS..QRRKL-KTR----QCL..SFC.......PAGVP---------------...IKD
LY6G_MOUSE/6-82GF....CVAL------EIEVIVDS..HRSKV-KSN----LCL..PIC.......PTTLD---------------NTEITG
TX101_CRIGR/143-219TQ....CYQG------KIELSGGG..MDSVL-HIK----GCTTAIGC.........RLM---------------AAITSV
LY6D_MOUSE/23-93YF....CKTV------TSVEP.....LNGNL-VRK----ECA..NSC........TSDY---------------SQQGHV
PSCA_HUMAN/23-93EQ....CWTA------RIRAV.....GLLTV-ISK----GCS..LNC...........V---------------DDSQDY
LYPD4_HUMAN/142-233ST....CYSS------TLKFQAGF..LNTTF-LLM----GCAREHNQ..........LL---------------ADFHHI
UPAR_HUMAN/216-294NQ....CLVA------TGTHEPKN....QSY-MVR----GCATASMC.......QHAHL---------------GDAFSM
LY6E_MOUSE/23-99HY....CITL------SAAAGFGN.VNLGYT-LNK----GCS..PIC.........PSE---------------NVNLNL
LY6I_MOUSE/29-105GF....CVAQ------EEEFIANS..QRKKV-KSR----SCH..PFC.......PDEIE---------------KKFILD
LYNX1_MOUSE/23-92TY....CMTT------RTYFT.....PYRMK-VRK----SCV..PSC..........FE---------------TVYDGY
TX101_MOUSE/141-217TQ....CYQG------RLEFSGGG..MDATV-QVK----GCTTTIGC.........RLM---------------AMIDSV
LY6F_MOUSE/29-105AV....CISQ------QVELIVDS..QRRKV-KNK----LCF..PFC.......PANLE---------------NMEILG
Q810N3_MOUSE/141-219K.....CYAA------SLGVHGGD..LSAIF-SIS----GCLNSSHT.........YLL---------------NNQNTI
UPAR_RAT/27-101DL....CRTT------VLREWEDA..EELEV-VTR----GCAHKEKT........NRTM---------------SYRMGS
CD59_PIG/28-96DA....CIFV------EAV.........PPK-TYY----QCWRFDEC.........NFD---------------FISRNL
UPAR_HUMAN/25-99DL....CRTT------IVRLWEEG..EELEL-VEK----SCTHSEKT........NRTL---------------SYRTGL
CD59_SHV21/22-89DS....CLIA------KA..........GSG-VYY----RCWKFDDC.........SFK---------------RISNQL
Q9TVA9_BOVIN/1-75DL....CRTT------VLSVWEGG..NEMNV-VRK----GCTHPDKT........NRSM---------------SYRAAD
LY6E_CHICK/23-96EH....CVTT------YVGVGIGG..KSGQS-ISK----GCS..PVC...........P---------------SAGINL
UPAR_BOVIN/211-289NQ....CLEA------TGTKGLRN....PSY-TIR----GCAAPSWC.......QSLHV---------------AEAFDL
LYPD4_MOUSE/142-233SS....CYSS------TLKFQAGN..LNTTF-LIM----GCARDSHK..........LL---------------ADFQHI
UPAR_RAT/216-295NQ....CLEA------TGLDVLGN....RSY-TVR----GCATASWC.......QGSHV---------------ADSFQ.
Q9R119_CRIGR/21-95DL....CRTT------VLHEWEDD..NELEL-EMR----DCAHYEKT........NRTM---------------SYRVNS
LY6H_HUMAN/28-111TV....CASV------RITDPSSS..RKDHS-VNK----MCA..SSCDFVKRHFFSDYL---------------MGFINS
CD59A_MOUSE/26-94DS....CLYA------VA..........GMQ-VYQ----RCWKQSDC.........HGE---------------IIMDQL
LY6E_HUMAN/23-99NY....CVTV------SASAGIGNLVTFGHS-LSK----TCS..PAC.........PIP---------------E.GVNV
Q63316_RAT/5-82GV....CAIQ------VAEVVMSS..VRQKV-KDH----ICL..PVC.......PTSPQ---------------TTEILG
CD59_AOTTR/28-95DS....CLIA------KA..........GSR-VYY----RCWKFEDC.........TFS---------------RVSNQL
LYPD5_HUMAN/135-214TA....CFQG------NGRMTVGN..FSVPV-YIR----TCHR.PSC.........TTE---------------GTTSPW

PF02988

Q9PU34_9SAUR/20-103DQ----CGTV------LMEVSSAP--ISFRT-IHR----NCFSSSLC------KLERFD---------------INIGHD
Q9PTC5_PSETE/20-102DA----CVTF------QTEVIRAP--VSLSL-ISK----SCGTSDTC------HLNYLE---------------TSPHNE
PA2I_CRODU/20-102DV----CGKV------LLEISSAS--LSVRT-VHK----NCFSSSIC------KLGQFD---------------VNIGHH
PLIGB_ELAQU/20-102DT----CVTY------QTEVIRPP--LSITF-TAK----TCGTSDTC------HLDYVE---------------ANPHTE
PLIGA_ELAQU/20-103DQ----CGKV------LLEISSAP--LSIRS-SHR----NCFSSSLC------KLEHFD---------------VNTGQE

PF00087

NXLH_PSEAU/22-85EL----CCTK......TW.CDQWCQ.DRGPR.LEM----GCT--ATC------------------------------PRR
NXL1_NOTSC/22-84NL----CYTK......TW.CDAFCS.SRGKV.VEL----GCA--ATC------------------------------PIA
TXW1_OPHHA/22-82DT----CYST......FW.ND...H..HGVK.IER----GCG--..C------------------------------PRV
NXS1_BOUCH/1-61TN----CYEK......RW.HD...H..RGTI.IER----GCG--..C------------------------------PTV
CX1_NAJMO/1-60NL----CY.K......MT.MR...A.APMVP.VKR----GCI--DVC------------------------------P.K
NXLH_BUNMU/25-87KY----CFKE......SW.RE...A..RGTR.IER----GCA--ATC------------------------------PKG
NXS2_NAJHA/1-60N.----CYKK......RW.RD...H..RGTI.IER----GCG--..C------------------------------PSV
TX510_DENJA/1-57NS----CYKS......IW.AD...H..RGTI.IKR----GCG--..C------------------------------PRV
NXL1_ACAAN/1-63NV----CFTR......TW.CDAFCS.SRGKV.VEL----GCA--ATC------------------------------PIV
NXS1_BUNFA/1-63..----CYIKTDCQNKTW.NT...H..RGSR.TDR----GCG--..C------------------------------PKV
NXS1_BOUAN/1-60N.----CYRK......QW.SD...H..RGTI.IER----GCG--..C------------------------------PTV
TXW1C_HEMHA/1-60NI----CYEK......RW.SG...H...GMQ.IEK----GCV--ASC------------------------------PSF
NXLB_PSETE/1-65EV----CYTE......TW.CDGFCG.IRGKR.VEL----GCA--ATC------------------------------PTP
NXLB1_BUNMU/22-86DI----CFLK......VS.CEQFC.PIRGPV.IEQ----GCA--ATC------------------------------PEF
NXS3_NAJMO/1-61TN----CYKK......RW.RD...H..RGYK.TER----GCG--..C------------------------------PTV
NXL2_BUNFL/1-65DI----CFTK......AF.CDRWCS.SRGPV.IEQ----GCA--ATC------------------------------PEF
TXW9A_NAJKA/1-63KI----CFKK......LH.QR...R..PLSR.YIR----GCA--DTC------------------------------PVG
NXS3_NAJHA/1-60N.----CYKK......QW.SG...H..RGTI.IER----GCG--..C------------------------------PSV
NXL1_NAJME/1-64DL----CYTK......KW.CADWCT.SRGKV.IEL----GCV--ATC------------------------------PKV
NXS1_DENJA/1-59NS----CYKK......TW.SD...H..RGTI.IER----GCG--..C------------------------------PKV
CX10_NAJHA/1-60NL----CY.K......MF.MV...S.TSTVP.VKR----GCI--DVC------------------------------P.K
NXL1_LATSE/22-84EI----CYVK......SW.CNAWCS.SRGKV.LEF----GCA--ATC------------------------------PSV
TX496_DENVI/1-59KT----CY.K.......F.VT...K.LPGVI.LAR----GCG--..C------------------------------PKK
TXM2_DENAN/22-85NV----CF.K......RWHYV...T.PKNYD.IIK----GCA--ATC------------------------------PKV
NXL1_NAJOX/1-65NL----CYTK......TW.CDAWCG.SRGKV.IEL----GCA--ATC------------------------------PTV
NXL1_DENJA/1-64DI----CYTK......TW.CDGFCS.QRGKR.VEL----GCA--ATC------------------------------PKV
CX2_NAJME/1-61NL----CF.K......GT.LK...F.PKKTT.YNR----GCA--ATC------------------------------P.K
NXSC_LATSE/22-82SS----CYHK......QW.SD...F..RGTI.IER----GCG--..C------------------------------PTV
CX11_NAJHH/1-62NL----CF.K......TT.LK..KL.PLKIP.IKR----GCA--ATC------------------------------P.K
TX022_DENAN/1-59NS----CY.K......MF.IR...T.SPDYI.SDR----GCG--..C------------------------------PTA
TXW2_NAJHH/1-60NI----CYEK......RW.NS...H..QGVE.IK.----GCV--ASC------------------------------PEF
TX311_DENAN/22-80NS----CY.K......RS.LP...K.IPLII.IGR----GCG--..C------------------------------PLT
NXL1V_BUNMU/22-87NL----CYRK......MW.CDVFCS.SRGKV.VEL----GCA--ATC------------------------------PSK
CXH_HEMHA/1-62NI----CY.K......MT.LK...K.TPMKLSVKR----GCA--ATC------------------------------PSE
NXL4_OPHHA/1-65DL----CYMK......TW.CDVFCG.TRGRV.IEL----GCT--ATC------------------------------PTV
NXL1_NAJHC/1-64NI----CYTK......TW.CDNFCG.MRGKR.VDL----GCA--ATC------------------------------PTV
TX48_DENJA/1-59NT----CY.K......MF.IR...T.SREYI.SER----GCG--..C------------------------------PTA
TXW5_NAJNA/1-61NI----CF.K......RF.NR...I..LGKR.YDL----GCA--ATC------------------------------PTV
NXL1_ASTST/1-63NV----CFVK......TW.CDGFCN.TRGER.IIM----GCA--ATC------------------------------PTA
TSYL3_DENPO/1-64NL----CFKR......RH.YV...V.PKIYD.ITR----GCV--ATC------------------------------PIP
CXH48_ASPSC/1-63NL----CY.K......MS.NR..MY.PPGFN.VRR----GCA--ETC------------------------------PRR
CX1_HEMHA/1-61NL----CY.K......MT.ML...K.MPKIP.IKR----GCT--DAC------------------------------P.K
NXL1_ASPSC/1-63NI----CYLK......AW.CDAWCS.SRGKK.LEF----GCA--ATC------------------------------PTV
TXAC_DENPO/1-60NS----CY.R......KS.RR...H.PPKMV.LGR----GCG--..C------------------------------PPG
TXW11_NAJHH/1-64NQ----CF.K......RF.NE..RK.LLGKR.YTR----GCA--ATC------------------------------PEA
CXH32_ASPSC/1-62DL----CY.K......MN.FK..LL.PKKLS.IKR----GCT--DTC------------------------------P.K
NXS1_ACAAN/1-61SS----CYKK......TW.RD...H..RGTI.IER----GCG--..C------------------------------PRV
TXW10_NAJNI/1-64KI----CF.K......RFDQR...K.LLGKR.YTR----GCA--VTC------------------------------PVA

PF06211

Q9DFZ0_DANRE/1-107NA----CFTK------VLDPLNT-----NSP-LTH----GCVDSLLNSADVCSSKNVDI-----------------SSGS
BAMBI_HUMAN/4-111SA----CFSR------LLDPQNS-----NSP-LTH----GCLDSLASTTDICQAKQARN-----------------HSGT
Q68F57_XENLA/4-112NA----CFTK------LLYPQNS-----NSP-LTH----GCLDSLGSTTEPCKASAEHN-----------------HT.V
Q6GQM7_DANRE/4-110NA----CFTR------TLDPQST-----NSP-LSH----GCYDPMLNSGKTCHSESTFD-----------------RIHG

PF01064

O16623_CAEEL/77-187HY----CTYE------QEYIRNDF--GDAYT-SINSPSRGCSDLEYAEDLNS.PNMCRL..................L..
O16623_CAEEL/298-408HY----CIYE------RDLTRNEF--GDVFP-RTAKPRRGCSDPNYTQDLSR.KNMCKI..................E..
ACV1C_RAT/26-100GA----CWAS------VMLTNG..--..KEQ-VSK....SCVSLPELNAQ....VFCHS..................SNN
Q24229_DROME/34-128PS----CYVL------WSVNE...--..TTG-ILRIKMKGCFTDMHECNQ....TECVT..................SAE
O73736_DANRE/26-99DQ----CYTS------VIISND..--..VTT-FKR....GCLIGPASKR.....MTCSA.................TASA
Q6PUB8_ANOGA/12-110IQ----CWKS------RTR.DPEG--..NEN-VQR....GCTTEHEQLP.....LYCSQNQKPNTGDSGGPKKRHVSSTG
Q95UF3_ANCCA/52-144AA----CFHF------MKEVYNSE--..LRR-METVHQYGCATLEKGSSASH..LTCNS.................FRSP
Q9D7E5_MOUSE/28-111EV----CGVS------VGTSEQKE--..EEV-IER...KGCLPRAQCPLLGHATYWSRS.................Y...
Q8MPR1_CRAGI/23-106GL----CLTL------RAYRKDG.--..TIK-IRY....RCIEKVDLGPLDGDVFECLT..................SNP
Q7QGF7_ANOGA/72-163GS----CFVS------VEAVLDEE--..TKQ-LVPEYSHGCMSPEQGGGL....LQCKVG................TVSP
O42338_XENLA/57-136GQ----CFAM------IEEDDHG.--..DII-LTS....GCMKMEGSD......FQCKD..................SPK
Q91595_XENLA/28-108GM----CLVS------IFVKDG..--..IET-HNS....ECVANSKLVPVDR.PIMCEP..................FPS
Q86SD0_CIOIN/20-107GV----CYAM------TEVLPISK--..NIL-TQR....GCFRKNRLVPYNR.PFVCEP.................VNKS
ACVL1_RAT/33-104AW----CTVV------LVREQGR.--..HPQ-VYR....GCGSLNQ........ELCLG.................RPTE
ACVR1_HUMAN/33-107QQ----CFSS------LSINDG..--..FHV-YQK....GCFQVYEQGK.....MTCKT.................PPSP
BMPR2_MOUSE/32-131ST----CYGL------WEKSKGD.--..INL-VKQ....GCWSHIGDPQECH.YEECVVT...............TTPPS
O73801_TAKRU/34-111GA----CMAS------TYYVER..--..KEQ-HIR....ICINRDSLVPPGQ.PFYCLS..................AEG
Q7YXA1_CRAGI/31-115FQ----CFTG------LRLVVENG--EQVEI-ISK....GCMSEEENSI.....LQCKG.................HLVP
BMR1B_HUMAN/30-110GY----CFTM------IEEDDSG.--..LPV-VTS....GCLGLEGSD......FQCRD..................TPI
Q6DEV8_XENTR/28-118LH----CYAS------WRNNSGF.--..IEL-VKK....GCWLDDFNCYDR...QECIA.................KEEN
Q23975_DROME/127-208GF----CFTS------VEKNSDG.--..SII-FSY....SCMVVKYNMQRSK.PSECLT..................SNE
Q7Q709_ANOGA/56-159PF----CYTL------WTFDI...--..VKN-VTRVVVQGCWGSNDDQESCS.SNECVS...................TT
O16149_BRUPA/78-172AS----CFHF------TEEIYDKT--..LKQ-VETMHLFGCAPLTRGSGGSY..FTCKA.................HLVA
TGFR1_RAT/30-108GL----CFVS------VTETTD..--..KVI-HNS....MCIAEIDLIPRDR.PFVCAP.................SSKT
Q24326_DROME/69-159GS----CSSA------VQQLYDET--..TGM-YEEERTYGCMPPEDNGGF....LMCKV.................AAVP
Q5R5N7_PONAB/32-109GA----CMVS------IFNLDG..--..MEH-HVR....TCIPKVELVPAGK.PFYCLS..................SED

PF00021

LYPD3_RAT/142-224PGFTLSG...........SC.C-QG-PRCN-------
CD59_CHLAE/28-95KESELQY...........FC.C-KK-DLCN-------
CD59_RAT/25-92EIANVQY...........RC.C-QA-DLCN-------
Q9R119_CRIGR/210-288SHPN..I...........SC.C-DG-SGCN-------
LY6D_HUMAN/23-93SSGTSST...........QC.C-QE-DLCN-------
LY6A_MOUSE/29-105TKVNVKT...........SC.C-QE-DLCN-------
CD59_RABIT/28-95EENSLKY...........NC.C-RK-DLCN-------
TX101_RAT/141-217GPMTVKE...........TC.S-YQ-SFLH-------
LYPD5_MOUSE/133-212TSIDLQG...........YC.C-EG-HLCN-------
Q63318_RAT/29-105TVVYTKV...........SC.C-NT-DLCN-------
CD59_HUMAN/28-95RENELTY...........YC.C-KK-DLCN-------
LY6C2_MOUSE/29-102PNIRERT...........SC.C-SE-DLCN-------
LY6G_MOUSE/6-82NAVNVKT...........YC.C-KE-DLCN-------
TX101_CRIGR/143-219GPMTVKE...........TC.S-YH-SLLQ-------
LY6D_MOUSE/23-93SSGSEVT...........QC.C-QT-DLCN-------
PSCA_HUMAN/23-93YVGKKNI...........TC.C-DT-DLCN-------
LYPD4_HUMAN/142-233GSIKVTEVLNILEKSQIVGAAS-SR-QDPA-------
UPAR_HUMAN/216-294NHID..V...........SC.C-TK-SGCN-------
LY6E_MOUSE/23-99GVASVNS...........YC.C-QS-SFCN-------
LY6I_MOUSE/29-105PNTKMNI...........SC.C-QE-DLCN-------
LYNX1_MOUSE/23-92SKHASAT...........SC.C-QY-YLCN-------
TX101_MOUSE/141-217GPMTVKE...........TC.S-YQ-SFLQ-------
LY6F_MOUSE/29-105TTVNVNT...........SC.C-KE-DLCN-------
Q810N3_MOUSE/141-219GIISIKE...........TLES-NV-TLSS-------
UPAR_RAT/27-101VIVSLTE...........TV.C-AT-NLCN-------
CD59_PIG/28-96AEKKLKY...........NC.C-RK-DLCN-------
UPAR_HUMAN/25-99KITSLTE...........VV.C-GL-DLCN-------
CD59_SHV21/22-89SETQLKY...........HC.C-KK-NLCN-------
Q9TVA9_BOVIN/1-75QIITLSE...........TV.C-RS-DLCN-------
LY6E_CHICK/23-96GIAAASV...........YC.C-DS-FLCN-------
UPAR_BOVIN/211-289THVN..V...........SC.C-TG-SGCN-------
LYPD4_MOUSE/142-233GSIRVTEVINVLDKSEAVSAGH-CS-QGIS-------
UPAR_RAT/216-295THVNLSI...........SC.C-NG-SGCN-------
Q9R119_CRIGR/21-95KIISLAE...........VV.C-AT-DVCN-------
LY6H_HUMAN/28-111GILKVDV...........DC.C-EK-DLCN-------
CD59A_MOUSE/26-94EETKLKF...........RC.C-QF-NLCN-------
LY6E_HUMAN/23-99GVASMGI...........SC.C-QS-FLCN-------
Q63316_RAT/5-82TVVDMKI...........SC.C-NT-DLCN-------
CD59_AOTTR/28-95SENELKY...........YC.C-KK-NLCN-------
LYPD5_HUMAN/135-214TAIDLQG...........SC.C-EG-YLCN-------

PF02988

Q9PU34_9SAUR/20-103SYLRGRI-----------HC-C-DE-ARCEA------
Q9PTC5_PSETE/20-102LTVKTKR-----------TC-C-TG-EECKT------
PA2I_CRODU/20-102SYIRGRI-----------NC-C-EK-ELCED------
PLIGB_ELAQU/20-102LTLRAKR-----------AC-C-TG-DECQT------
PLIGA_ELAQU/20-103TYLRGRI-----------HC-C-DE-KKCEG------

PF00087

NXLH_PSEAU/22-85MP.GLDF-----------TC-C.TT.DNCN-------
NXL1_NOTSC/22-84KS.YEDV-----------TC-C.ST.DNCN-------
TXW1_OPHHA/22-82NP.PISI-----------IC-C.KT.DKCN-------
NXS1_BOUCH/1-61KP.GVKL-----------NC-C.TT.DKCN-------
CX1_NAJMO/1-60SSLLIKY-----------MC-C.NT.NKCN-------
NXLH_BUNMU/25-87SVYGLYV-----------LC-C.TT.DDCN-------
NXS2_NAJHA/1-60KK.GVGI-----------YC-C.KT.NKCN-------
TX510_DENJA/1-57KS...KI-----------KC-C.KS.DNCN-------
NXL1_ACAAN/1-63KS.YNEV-----------KC-C.ST.DKCN-------
NXS1_BUNFA/1-63KP.GINL-----------RC-C.KT.DKCN-------
NXS1_BOUAN/1-60KP.GVKL-----------HC-C.TT.EKCN-------
TXW1C_HEMHA/1-60ESHYKFL-----------LC-C.RI.ENCN-------
NXLB_PSETE/1-65KKTGIDI-----------QC-C.ST.DDCN-------
NXLB1_BUNMU/22-86RSNDRSL-----------LC-C.TT.DNCN-------
NXS3_NAJMO/1-61KK.GIQL-----------HC-C.TS.DNCN-------
NXL2_BUNFL/1-65TSRYKSL-----------LC-C.TT.DNCN-------
TXW9A_NAJKA/1-63YP.KEMI-----------EC-C.ST.DKCN-------
NXS3_NAJHA/1-60KK.GIEI-----------NC-C.TT.DKCN-------
NXL1_NAJME/1-64KP.YEQI-----------TC-C.ST.DNCN-------
NXS1_DENJA/1-59KQ.GIHL-----------HC-C.QS.DKCN-------
CX10_NAJHA/1-60NSALVKY-----------VC-C.NT.DRCN-------
NXL1_LATSE/22-84NT.GTEI-----------KC-C.SA.DKCN-------
TX496_DENVI/1-59EIFRKSI-----------HC-C.RS.DKCN-------
TXM2_DENAN/22-85DN.NDPI-----------RC-C.GT.DKCN-------
NXL1_NAJOX/1-65ES.YQDI-----------KC-C.ST.DDCN-------
NXL1_DENJA/1-64KT.GVEI-----------KC-C.ST.DYCN-------
CX2_NAJME/1-61SSLLVKY-----------VC-C.NT.NKCN-------
NXSC_LATSE/22-82KP.GINL-----------SC-C.ES.EVCN-------
CX11_NAJHH/1-62SSALLKV-----------VC-C.ST.DKCN-------
TX022_DENAN/1-59MW.PYQT-----------AC-C.KG.DRCN-------
TXW2_NAJHH/1-60ESRFRYL-----------LC-C.RI.DNCN-------
TX311_DENAN/22-80LP.FLRI-----------KC-C.TS.DKCN-------
NXL1V_BUNMU/22-87KP.YEEV-----------TC-C.ST.DKCN-------
CXH_HEMHA/1-62RP.LVQV-----------EC-C.KT.DKCN-------
NXL4_OPHHA/1-65KP.HEQI-----------TC-C.ST.DNCN-------
NXL1_NAJHC/1-64KP.GVDI-----------KC-C.ST.DNCN-------
TX48_DENJA/1-59MW.PYQT-----------EC-C.KG.DRCN-------
TXW5_NAJNA/1-61KT.GI.V-----------QC-C.ST.DKCN-------
NXL1_ASTST/1-63KS.GVHI-----------AC-C.ST.DNCN-------
TSYL3_DENPO/1-64EN.YDSI-----------HC-C.KT.EKCN-------
CXH48_ASPSC/1-63NR.LLEV-----------VC-CCDT.DNCN-------
CX1_HEMHA/1-61SSLLVKV-----------VC-C.NK.DKCN-------
NXL1_ASPSC/1-63KP.GVDI-----------SC-C.DT.DNCN-------
TXAC_DENPO/1-60DD.YLEV-----------KC-C.TSPDKCN-------
TXW11_NAJHH/1-64KP.REIV-----------EC-C.TT.DRCN-------
CXH32_ASPSC/1-62SSLLVKV-----------VC-C.DT.DKCN-------
NXS1_ACAAN/1-61KP.GIRL-----------IC-C.KT.DECN-------
TXW10_NAJNI/1-64KP.REIV-----------EC-C.ST.DGCN-------

PF06211

Q9DFZ0_DANRE/1-107SSP...V-----------EC-CH-D-DMCNYRGLHD-
BAMBI_HUMAN/4-111TIPT..L-----------EC-CH-E-DMCNYRGLHD-
Q68F57_XENLA/4-112AVPTLRL-----------EC-CH-E-DMCNYRGLHD-
Q6GQM7_DANRE/4-110SAT...L-----------QC-CH-E-DMCNYRGLQD-

PF01064

O16623_CAEEL/77-187...NGLL-----------EC-QCST-PYCNRDQPFEV
O16623_CAEEL/298-408...NDWL-----------QC-ICDT-EFCNREQNIEV
ACV1C_RAT/26-100...VTKT-----------EC-CF.T-DFCNNITQHLP
Q24229_DROME/34-128PRQGNIH-----------FC-CCKG-SRCNSNQKYIK
O73736_DANRE/26-99...SHVV-----------EC-CS.Q-HMCNANVSKET
Q6PUB8_ANOGA/12-110...MYNI-----------EC-CT.G-DYCNNGSFPEL
Q95UF3_ANCCA/52-144HRTPKSI-----------AC-CYEG-NYCNLNITPPP
Q9D7E5_MOUSE/28-111...SLRH-----------QC-CE.Q-DLCNAAASQPP
Q8MPR1_CRAGI/23-106MASISSK-----------LC-CNDE-DFCNKHLFPTF
Q7QGF7_ANOGA/72-163QLHGKSI-----------VC-CDNE-DLCNQDLQPPY
O42338_XENLA/57-136ALSRRTI-----------EC-CR.T-DFCNRDLEPTL
Q91595_XENLA/28-108TAIYIKV-----------DC-CE.T-DFCNKKLPSPT
Q86SD0_CIOIN/20-107...NHQV-----------IC-CK.T-DFCNHPEAMEA
ACVL1_RAT/33-104...FVNH-----------HC-CY.R-SFCNHNVSLML
ACVR1_HUMAN/33-107...GQAV-----------EC-CQ.G-DWCNRNITAQL
BMPR2_MOUSE/32-131IQNGTYR-----------FC-CCST-DLCNVNFTENF
O73801_TAKRU/34-111...LLNT-----------HC-CY.E-DYCNSIDLKVP
Q7YXA1_CRAGI/31-115HRLPRTV-----------EC-CNDE-DYCNDFLDPVY
BMR1B_HUMAN/30-110PHQRRSI-----------EC-CTER-NECNKDLHPTL
Q6DEV8_XENTR/28-118...PQVF-----------FC-CCEG-NYCNKKFTHLP
Q23975_DROME/127-208RFDTYRI-----------DC-CK.S-DFCNKNENMKR
Q7Q709_ANOGA/56-159ETPTRHF-----------FC-CCSG-DNCNGNFSYLP
O16149_BRUPA/78-172HARPKSI-----------AC-CQEG-NYCNRNLSVPA
TGFR1_RAT/30-108...GAVT-----------YC-CN.Q-DHCNKIELPTT
Q24326_DROME/69-159HLHGKNI-----------VC-CDKE-DFCNRDLYPTY
Q5R5N7_PONAB/32-109...LRNT-----------HC-CY.T-DYCNRIDLRVP

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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