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5240  structures 9026  species 0  interactions 119635  sequences 3238  architectures

Clan: Peptidase_PA (CL0124)


Peptidase clan PA Add an annotation

This clan contains a diverse set of peptidases with the trypsin fold.

This clan contains 26 families and the total number of domains in the clan is 119635. The clan was built by A Bateman.


This clan contains the following 26 member families:

DUF1986 DUF316 Mycop_pep_DUF31 Peptidase_C107 Peptidase_C24 Peptidase_C3 Peptidase_C30 Peptidase_C37 Peptidase_C3G Peptidase_C4 Peptidase_C62 Peptidase_S29 Peptidase_S3 Peptidase_S30 Peptidase_S31 Peptidase_S32 Peptidase_S39 Peptidase_S46 Peptidase_S55 Peptidase_S6 Peptidase_S64 Peptidase_S7 Peptidase_S76 Pico_P2A Trypsin Trypsin_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Trypsin (PF00089) 76462 (63.9%) View
Trypsin_2 (PF13365) 38513 (32.2%) View
Peptidase_S46 (PF10459) 1744 (1.5%) View
Peptidase_S55 (PF05580) 1336 (1.1%) View
DUF316 (PF03761) 330 (0.3%) View
Mycop_pep_DUF31 (PF01732) 282 (0.2%) View
Peptidase_S64 (PF08192) 191 (0.2%) View
DUF1986 (PF09342) 147 (0.1%) View
Peptidase_S6 (PF02395) 134 (0.1%) View
Peptidase_C30 (PF05409) 115 (0.1%) View
Peptidase_C3 (PF00548) 111 (0.1%) View
Peptidase_S39 (PF02122) 106 (0.1%) View
Peptidase_S7 (PF00949) 37 (0.0%) View
Peptidase_S32 (PF05579) 33 (0.0%) View
Pfam family Num. domains Alignment
Peptidase_C3G (PF12381) 27 (0.0%) View
Peptidase_C107 (PF17222) 12 (0.0%) View
Peptidase_S3 (PF00944) 9 (0.0%) View
Pico_P2A (PF00947) 8 (0.0%) View
Peptidase_C4 (PF00863) 8 (0.0%) View
Peptidase_C62 (PF12380) 7 (0.0%) View
Peptidase_S30 (PF01577) 6 (0.0%) View
Peptidase_C37 (PF05416) 5 (0.0%) View
Peptidase_C24 (PF03510) 5 (0.0%) View
Peptidase_S76 (PF13611) 3 (0.0%) View
Peptidase_S31 (PF05578) 2 (0.0%) View
Peptidase_S29 (PF02907) 2 (0.0%) View
Total: 26 Total: 119635 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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