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3069  structures 22609  species 99  interactions 154021  sequences 1696  architectures

Clan: Peptidase_PA (CL0124)

Summary

Peptidase clan PA Add an annotation

This clan contains a diverse set of peptidases with the trypsin fold.

This clan contains 24 families and the total number of domains in the clan is 154021. The clan was built by A Bateman.

Members

This clan contains the following 24 member families:

DUF1986 DUF31 DUF316 Peptidase_C24 Peptidase_C3 Peptidase_C30 Peptidase_C37 Peptidase_C3G Peptidase_C4 Peptidase_C62 Peptidase_S29 Peptidase_S3 Peptidase_S30 Peptidase_S31 Peptidase_S32 Peptidase_S39 Peptidase_S46 Peptidase_S55 Peptidase_S6 Peptidase_S7 Peptidase_S76 Pico_P2A Trypsin Trypsin_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Trypsin_2 (PF13365) 62642 (40.7%) View
Trypsin (PF00089) 45666 (29.6%) View
Peptidase_S29 (PF02907) 17261 (11.2%) View
Peptidase_C3 (PF00548) 5564 (3.6%) View
Peptidase_S7 (PF00949) 4286 (2.8%) View
Peptidase_S6 (PF02395) 3984 (2.6%) View
Pico_P2A (PF00947) 2892 (1.9%) View
Peptidase_S30 (PF01577) 1862 (1.2%) View
Peptidase_S55 (PF05580) 1627 (1.1%) View
Peptidase_C4 (PF00863) 1471 (1.0%) View
Peptidase_S46 (PF10459) 1393 (0.9%) View
Peptidase_S3 (PF00944) 1093 (0.7%) View
Peptidase_C30 (PF05409) 1017 (0.7%) View
continued
Pfam family Num. domains Alignment
Peptidase_C37 (PF05416) 836 (0.5%) View
Peptidase_S39 (PF02122) 571 (0.4%) View
DUF31 (PF01732) 532 (0.3%) View
Peptidase_S32 (PF05579) 481 (0.3%) View
Peptidase_S31 (PF05578) 304 (0.2%) View
DUF316 (PF03761) 189 (0.1%) View
Peptidase_C24 (PF03510) 142 (0.1%) View
Peptidase_S76 (PF13611) 105 (0.1%) View
Peptidase_C3G (PF12381) 50 (0.0%) View
DUF1986 (PF09342) 40 (0.0%) View
Peptidase_C62 (PF12380) 13 (0.0%) View
Total: 24 Total: 154021 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 99 interactions for this clan. More...

Interacting families
A B
A2M Trypsin
A2M_N Trypsin
A2M_recep Trypsin
Alpha_E1_glycop Peptidase_S3
Alpha_E2_glycop Peptidase_S3
Bowman-Birk_leg Trypsin
CLIP Trypsin
Ecotin Trypsin
EGF Trypsin
Flavi_NS2B Peptidase_S7
FXa_inhibition Trypsin
Globin Trypsin
HCV_NS4a Peptidase_S29
Hepsin-SRCR Trypsin
Kringle Trypsin
Kunitz_BPTI Trypsin
Kunitz_legume Trypsin
Ldl_recept_a Trypsin
LRR_8 Trypsin
MHC_I Peptidase_S29
NGF Trypsin
Omptin Trypsin
Pacifastin_I Trypsin
PAN_1 Trypsin
PDZ Trypsin
Trypsin_2
PDZ_2 Trypsin_2
Peptidase_C3 Peptidase_C3
Peptidase_C30 Peptidase_C30
Peptidase_C37 Peptidase_C37
Peptidase_C4 Peptidase_C4
Peptidase_M14 Trypsin
Peptidase_S29 Flavi_DEAD
HCV_NS4a
HCV_NS5a_C
Peptidase_S29
Peptidase_S3 Alpha_E1_glycop
Alpha_E2_glycop
Peptidase_S3
Peptidase_S32 Peptidase_S32
Peptidase_S6 Peptidase_S6
Pertactin
Peptidase_S7 Flavi_DEAD
Flavi_NS2B
Kunitz_BPTI
Peptidase_S7
Pertactin Peptidase_S6
Pico_P2A Pico_P2A
Pro_Al_protease Trypsin
Propep_M14 Trypsin
Serpin Trypsin
Sushi Trypsin
Thrombin_light Trypsin
Tissue_fac Trypsin
Trypsin A2M_recep
Anophelin
Antistasin
Bowman-Birk_leg
Coagulase
CompInhib_SCIN
Ecotin
EGF
Fib_alpha
FXa_inhibition
Haemadin
Hepsin-SRCR
Hirudin
Kazal_1
Kazal_2
Kringle
Kunitz_BPTI
Kunitz_legume
LRR_8
NGF
Pacifastin_I
PDZ
PDZ_2
potato_inhibit
Pro_Al_protease
Prot_inhib_II
Sema
Serpin
SH3_1
Squash
SSI
Staphylokinase
Sushi
Thrombin_light
TIL
Tissue_fac
Triabin
Trypsin
WAP
Trypsin_2 Citrate_synt
Lys
PDZ
PDZ_2
Trypsin_2
VWA Trypsin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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