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981  structures 6188  species 24  interactions 88418  sequences 1676  architectures

Clan: Peptidase_MA (CL0126)

Summary

Peptidase clan MA Add an annotation

Clan MA is one of two zinc-dependent metallopeptidases that contain the HEXXH motif. The two histidines are zinc ligands. The structures of this clan show the active site is between its two sub-domains.

This clan contains 54 families and the total number of domains in the clan is 88418. The clan was built by A Bateman.

Members

This clan contains the following 54 member families:

Aspzincin_M35 Astacin BSP DUF1570 DUF2201_N DUF2268 DUF3152 DUF3633 DUF3810 DUF4157 DUF45 DUF955 Enhancin HRXXH M60-like Peptidase_M1 Peptidase_M10 Peptidase_M11 Peptidase_M13 Peptidase_M2 Peptidase_M27 Peptidase_M3 Peptidase_M30 Peptidase_M32 Peptidase_M35 Peptidase_M36 Peptidase_M4 Peptidase_M41 Peptidase_M43 Peptidase_M48 Peptidase_M4_C Peptidase_M50 Peptidase_M50B Peptidase_M54 Peptidase_M56 Peptidase_M57 Peptidase_M6 Peptidase_M61 Peptidase_M64 Peptidase_M66 Peptidase_M7 Peptidase_M8 Peptidase_M9 Peptidase_M91 Peptidase_MA_2 Peptidase_U49 Reprolysin Reprolysin_2 Reprolysin_3 Reprolysin_4 Reprolysin_5 SprT-like WLM Zn_peptidase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M48 (PF01435) 10571 (12.0%) View
Peptidase_M50 (PF02163) 8451 (9.6%) View
Peptidase_M3 (PF01432) 8043 (9.1%) View
Peptidase_M1 (PF01433) 7280 (8.2%) View
Peptidase_M41 (PF01434) 7039 (8.0%) View
DUF955 (PF06114) 5058 (5.7%) View
DUF45 (PF01863) 3481 (3.9%) View
Peptidase_M13 (PF01431) 3320 (3.8%) View
Peptidase_M10 (PF00413) 3213 (3.6%) View
Reprolysin (PF01421) 3201 (3.6%) View
SprT-like (PF10263) 2631 (3.0%) View
Astacin (PF01400) 2029 (2.3%) View
Peptidase_M4_C (PF02868) 1990 (2.3%) View
Peptidase_MA_2 (PF13485) 1955 (2.2%) View
Peptidase_M4 (PF01447) 1948 (2.2%) View
Peptidase_M56 (PF05569) 1807 (2.0%) View
Zn_peptidase (PF04228) 1671 (1.9%) View
Peptidase_M32 (PF02074) 1205 (1.4%) View
Peptidase_M8 (PF01457) 1086 (1.2%) View
Peptidase_M6 (PF05547) 820 (0.9%) View
M60-like (PF13402) 818 (0.9%) View
Peptidase_M2 (PF01401) 802 (0.9%) View
Peptidase_M61 (PF05299) 668 (0.8%) View
Peptidase_M50B (PF13398) 639 (0.7%) View
Enhancin (PF03272) 631 (0.7%) View
Peptidase_M9 (PF01752) 608 (0.7%) View
Peptidase_M43 (PF05572) 563 (0.6%) View
DUF2268 (PF10026) 528 (0.6%) View
continued
Pfam family Num. domains Alignment
DUF2201_N (PF13203) 492 (0.6%) View
DUF4157 (PF13699) 470 (0.5%) View
Reprolysin_5 (PF13688) 463 (0.5%) View
Peptidase_M36 (PF02128) 458 (0.5%) View
Reprolysin_2 (PF13574) 431 (0.5%) View
WLM (PF08325) 403 (0.5%) View
DUF3152 (PF11350) 313 (0.4%) View
Reprolysin_3 (PF13582) 288 (0.3%) View
Reprolysin_4 (PF13583) 268 (0.3%) View
Peptidase_M54 (PF07998) 267 (0.3%) View
BSP (PF04450) 266 (0.3%) View
Peptidase_M66 (PF10462) 252 (0.3%) View
Peptidase_M64 (PF09471) 251 (0.3%) View
Peptidase_M35 (PF02102) 234 (0.3%) View
Aspzincin_M35 (PF14521) 226 (0.3%) View
Peptidase_M11 (PF05548) 219 (0.2%) View
Peptidase_M27 (PF01742) 216 (0.2%) View
DUF3810 (PF12725) 206 (0.2%) View
DUF3633 (PF12315) 151 (0.2%) View
Peptidase_M91 (PF14891) 118 (0.1%) View
HRXXH (PF13933) 85 (0.1%) View
Peptidase_M7 (PF02031) 82 (0.1%) View
Peptidase_M30 (PF10460) 71 (0.1%) View
Peptidase_M57 (PF12388) 69 (0.1%) View
DUF1570 (PF07607) 34 (0.0%) View
Peptidase_U49 (PF10463) 29 (0.0%) View
Total: 54 Total: 88418 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 24 interactions for this clan. More...

Interacting families
A B
Peptidase_M2 Peptidase_M2
Peptidase_M13 Peptidase_M13_N
Reprolysin Disintegrin
Reprolysin
ADAM_CR
Peptidase_M50 Peptidase_M50
Peptidase_M3 Peptidase_M3
Peptidase_M3_N
Peptidase_M4 Peptidase_M4
Peptidase_M4_C
Peptidase_M41 AAA
Peptidase_M41
Peptidase_M4_C Peptidase_M4
Peptidase_M4_C
Peptidase_M1 Leuk-A4-hydro_C
Peptidase_M10 fn2
Hemopexin
Peptidase_M10
PG_binding_1
Inh
Peptidase_M10_C
Peptidase_M27 Peptidase_M27
Toxin_trans
Peptidase_M32 Peptidase_M32

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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