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1231  structures 21350  species 70  interactions 327829  sequences 2389  architectures

Clan: Peptidase_MA (CL0126)

Summary

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M48 (PF01435) 42051 (12.8%) View
Peptidase_M3 (PF01432) 32995 (10.1%) View
Peptidase_M50 (PF02163) 30618 (9.3%) View
DUF955 (PF06114) 26827 (8.2%) View
Peptidase_M41 (PF01434) 24536 (7.5%) View
Peptidase_M1 (PF01433) 20246 (6.2%) View
SprT-like (PF10263) 12366 (3.8%) View
DUF45 (PF01863) 11694 (3.6%) View
Peptidase_M56 (PF05569) 11410 (3.5%) View
DUF3267 (PF11667) 9359 (2.9%) View
Peptidase_M4_C (PF02868) 8811 (2.7%) View
Peptidase_M4 (PF01447) 8752 (2.7%) View
Zn_peptidase (PF04228) 8671 (2.6%) View
Peptidase_M13 (PF01431) 8596 (2.6%) View
Zn_peptidase_2 (PF04298) 6863 (2.1%) View
Peptidase_M10 (PF00413) 6707 (2.0%) View
DUF2268 (PF10026) 6021 (1.8%) View
Peptidase_M50B (PF13398) 5149 (1.6%) View
Reprolysin (PF01421) 4366 (1.3%) View
Peptidase_M60 (PF13402) 3855 (1.2%) View
Astacin (PF01400) 3536 (1.1%) View
Peptidase_M32 (PF02074) 3395 (1.0%) View
Peptidase_Mx (PF15887) 2433 (0.7%) View
Peptidase_M61 (PF05299) 2257 (0.7%) View
DUF3152 (PF11350) 2180 (0.7%) View
Peptidase_M6 (PF05547) 1951 (0.6%) View
Peptidase_M8 (PF01457) 1724 (0.5%) View
Peptidase_M9 (PF01752) 1535 (0.5%) View
DUF4953 (PF16313) 1215 (0.4%) View
Peptidase_M2 (PF01401) 1204 (0.4%) View
continued
Pfam family Num. domains Alignment
Peptidase_M43 (PF05572) 1181 (0.4%) View
DUF2201_N (PF13203) 1041 (0.3%) View
Peptidase_M36 (PF02128) 1017 (0.3%) View
DUF4157 (PF13699) 1012 (0.3%) View
Peptidase_M66 (PF10462) 921 (0.3%) View
WLM (PF08325) 919 (0.3%) View
Reprolysin_4 (PF13583) 908 (0.3%) View
Reprolysin_2 (PF13574) 904 (0.3%) View
Reprolysin_3 (PF13582) 880 (0.3%) View
Aspzincin_M35 (PF14521) 850 (0.3%) View
Reprolysin_5 (PF13688) 846 (0.3%) View
DUF3810 (PF12725) 794 (0.2%) View
Peptidase_M64 (PF09471) 703 (0.2%) View
BSP (PF04450) 599 (0.2%) View
Peptidase_M35 (PF02102) 513 (0.2%) View
Peptidase_M54 (PF07998) 472 (0.1%) View
Peptidase_Mx1 (PF15890) 469 (0.1%) View
Peptidase_M91 (PF14891) 431 (0.1%) View
DUF3633 (PF12315) 361 (0.1%) View
DUF4344 (PF14247) 340 (0.1%) View
Peptidase_M11 (PF05548) 320 (0.1%) View
Peptidase_M27 (PF01742) 248 (0.1%) View
HRXXH (PF13933) 178 (0.1%) View
Peptidase_M7 (PF02031) 155 (0.0%) View
Peptidase_M30 (PF10460) 144 (0.0%) View
Peptidase_M57 (PF12388) 123 (0.0%) View
DUF1570 (PF07607) 119 (0.0%) View
Peptidase_U49 (PF10463) 58 (0.0%) View
Total: 58 Total: 327829 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

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Species distribution

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Interactions

There are 70 interactions for this clan. More...

Interacting families
A B
AAA Peptidase_M41
ADAM_CR Reprolysin
Aspzincin_M35 Aspzincin_M35
Astacin MAM
MATH
ERAP1_C Peptidase_M1
fn2 Peptidase_M10
FTP Peptidase_M4_C
Hemopexin Peptidase_M10
PDZ Peptidase_M50
PepSY Peptidase_M4
Peptidase_M4_C
Peptidase_M1 Corona_S1
DUF3458
ERAP1_C
Leuk-A4-hydro_C
Peptidase_M1
Tachykinin
Peptidase_M10 Collagen
fn2
Hemopexin
Inh
Peptidase_M10
Peptidase_M10_C
TIMP
Peptidase_M13 Peptidase_M13
Peptidase_M13_N
Peptidase_M13_N Peptidase_M13
Peptidase_M2 Corona_S1
Peptidase_M2
Spike_rec_bind
Peptidase_M27 Peptidase_M27
SNARE
Synaptobrevin
Toxin_R_bind_C
Toxin_R_bind_N
Toxin_trans
Peptidase_M3 Peptidase_M3
Peptidase_M3_N
Peptidase_M32 Peptidase_M32
Peptidase_M3_N Peptidase_M3
Peptidase_M4 PepSY
Peptidase_M4_C
TIL
Peptidase_M41 AAA
Peptidase_M41
Peptidase_M43 Peptidase_M43
Peptidase_M48 Peptidase_M48
Peptidase_M4_C FTP
PepSY
Peptidase_M4
Peptidase_M4_C
TIL
Peptidase_M50 PDZ
Peptidase_M50
Peptidase_M61 PDZ_2
Peptidase_M64 Peptidase_M64
Peptidase_M7 SSI
Peptidase_M9_N Peptidase_M9
PG_binding_1 Peptidase_M10
Reprolysin ADAM_CR
Disintegrin
Reprolysin
Reprolysin_2 Inh
Peptidase_M10_C
Reprolysin_5 Reprolysin_5
TIMP
TIMP Peptidase_M10
Toxin_R_bind_C Peptidase_M27
Toxin_trans Peptidase_M27

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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