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736  structures 8304  species 0  interactions 130729  sequences 4518  architectures

Clan: vWA-like (CL0128)

Summary

von Willebrand factor type A Add an annotation

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This clan contains 19 families and the total number of domains in the clan is 130729. The clan was built by RD Finn.

Literature references

  1. Whittaker CA, Hynes RO; , Mol Biol Cell 2002;13:3369-3387.: Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. PUBMED:12388743 EPMC:12388743

Members

This clan contains the following 19 member families:

CobT_C Copine DUF1194 DUF2201 DUF444 DUF58 Integrin_beta ivWA Ku_N Med25_VWA Sec23_trunk Ssl1 Ste5_C Tfb4 VWA vWA-TerF-like VWA_2 VWA_3 VWA_CoxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
VWA (PF00092) 51876 (39.7%) View
VWA_2 (PF13519) 15074 (11.5%) View
DUF58 (PF01882) 13604 (10.4%) View
Sec23_trunk (PF04811) 9077 (6.9%) View
Copine (PF07002) 7750 (5.9%) View
VWA_3 (PF13768) 7494 (5.7%) View
VWA_CoxE (PF05762) 5796 (4.4%) View
Integrin_beta (PF00362) 4224 (3.2%) View
Ku_N (PF03731) 3155 (2.4%) View
DUF444 (PF04285) 2834 (2.2%) View
Tfb4 (PF03850) 1797 (1.4%) View
Ssl1 (PF04056) 1749 (1.3%) View
CobT_C (PF11775) 1524 (1.2%) View
DUF2201 (PF09967) 1322 (1.0%) View
DUF1194 (PF06707) 1284 (1.0%) View
Med25_VWA (PF11265) 1087 (0.8%) View
vWA-TerF-like (PF10138) 1040 (0.8%) View
Ste5_C (PF12194) 27 (0.0%) View
ivWA (PF19997) 15 (0.0%) View
Total: 19 Total: 130729 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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