Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
172  structures 3248  species 14  interactions 18743  sequences 56  architectures

Clan: Plasmid-antitox (CL0136)

Summary

Plasmid toxin-antitoxin system Add an annotation

The families in this clan are plasmid encoded anti-toxins involved in plasmid maintenance. The plasmid encodes both a toxin and an antitoxin. Upon loss of the plasmid the antitoxin is inactivated more rapidly than the toxin. This allows the toxin to interact with its target thus killing the cell or impeding growth.

This clan contains 12 families and the total number of domains in the clan is 18743. The clan was built by J Mistry.

Literature references

  1. Anantharaman V, Aravind L; , Genome Biol 2003;4:R81.: New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. PUBMED:14659018 EPMC:14659018
  2. Tian QB, Ohnishi M, Tabuchi A, Terawaki Y; , Biochem Biophys Res Commun 1996;220:280-284.: A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1. PUBMED:8645296 EPMC:8645296
  3. Grady R, Hayes F; , Mol Microbiol 2003;47:1419-1432.: Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. PUBMED:12603745 EPMC:12603745

Members

This clan contains the following 12 member families:

BrnT_toxin Gp49 HigB-like_toxin MqsR_toxin ParE-like_toxin ParE_toxin PHD_like PhdYeFM_antitox REGB_T4 RelE YafQ_toxin YoeB_toxin

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PhdYeFM_antitox (PF02604) 5831 (31.1%) View
ParE_toxin (PF05016) 5615 (30.0%) View
Gp49 (PF05973) 1893 (10.1%) View
BrnT_toxin (PF04365) 1275 (6.8%) View
YoeB_toxin (PF06769) 1162 (6.2%) View
HigB-like_toxin (PF05015) 1074 (5.7%) View
YafQ_toxin (PF15738) 931 (5.0%) View
RelE (PF06296) 556 (3.0%) View
ParE-like_toxin (PF15781) 202 (1.1%) View
MqsR_toxin (PF15723) 138 (0.7%) View
PHD_like (PF12910) 65 (0.3%) View
REGB_T4 (PF10715) 1 (0.0%) View
Total: 12 Total: 18743 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
Fic PhdYeFM_antitox
ParE_toxin ParD_antitoxin
ParE_toxin
PhdYeFM_antitox
RelB
PHD_like PHD_like
PhdYeFM_antitox Fic
ParE_toxin
PhdYeFM_antitox
PIN
YoeB_toxin
RelB ParE_toxin
Ribosom_S12_S23 ParE_toxin
YoeB_toxin YoeB_toxin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...