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1038  structures 22180  species 26  interactions 484933  sequences 1368  architectures

Clan: HAD (CL0137)

Summary

HAD superfamily Add an annotation

This clan represents the haloacid dehalogenase (HAD) superfamily that includes a diverse range of enzymes that use an asp carboxylate as a nucleophile [1].

This clan contains 22 families and the total number of domains in the clan is 484933. The clan was built by A Bateman.

Literature references

  1. Koonin EV, Tatusov RL; , J Mol Biol 1994;244:125-132.: Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. PUBMED:7966317 EPMC:7966317
  2. Aravind L, Galperin MY, Koonin EV; , Trends Biochem Sci 1998;23:127-129.: The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold. PUBMED:9584613 EPMC:9584613

Members

This clan contains the following 22 member families:

5_nucleotid Acid_phosphat_B Acid_PPase Cation_ATPase DUF2608 DUF705 HAD HAD_2 Hydrolase Hydrolase_3 Hydrolase_6 Hydrolase_like LNS2 NIF NT5C PGP_phosphatase PMM PNK3P Put_Phosphatase S6PP Trehalose_PPase UMPH-1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Hydrolase (PF00702) 137966 (28.5%) View
HAD_2 (PF13419) 112320 (23.2%) View
Hydrolase_3 (PF08282) 95943 (19.8%) View
Hydrolase_like (PF13242) 40384 (8.3%) View
HAD (PF12710) 25601 (5.3%) View
Hydrolase_6 (PF13344) 18937 (3.9%) View
Trehalose_PPase (PF02358) 10776 (2.2%) View
Acid_phosphat_B (PF03767) 10639 (2.2%) View
Cation_ATPase (PF13246) 5806 (1.2%) View
NT5C (PF06941) 5573 (1.1%) View
S6PP (PF05116) 5372 (1.1%) View
NIF (PF03031) 5368 (1.1%) View
continued
Pfam family Num. domains Alignment
PNK3P (PF08645) 3178 (0.7%) View
PMM (PF03332) 1287 (0.3%) View
5_nucleotid (PF05761) 1172 (0.2%) View
LNS2 (PF08235) 1052 (0.2%) View
Put_Phosphatase (PF06888) 874 (0.2%) View
PGP_phosphatase (PF09419) 759 (0.2%) View
DUF2608 (PF11019) 644 (0.1%) View
Acid_PPase (PF12689) 621 (0.1%) View
UMPH-1 (PF05822) 554 (0.1%) View
DUF705 (PF05152) 107 (0.0%) View
Total: 22 Total: 484933 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 26 interactions for this clan. More...

Interacting families
A B
AAA_33 PNK3P
Acid_phosphat_B Acid_phosphat_B
Acid_PPase Acid_PPase
Cation_ATPase_N Hydrolase
E1-E2_ATPase Hydrolase
HAD HAD
HAD_2 HAD_2
HMA Hydrolase
Hydrolase Cation_ATPase_C
E1-E2_ATPase
Hydrolase
Hydrolase_3 Hydrolase_3
Hydrolase_6 Hydrolase_6
Hydrolase_like
Hydrolase_like Hydrolase_6
Hydrolase_like
NIF NIF
PTCB-BRCT
RNA_pol_Rpb1_R
NT5C NT5C
PMM PMM
PNK3P AAA_33
PNK3P
S6PP S6PP
ubiquitin NIF
UMPH-1 UMPH-1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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