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305  structures 12397  species 12  interactions 32115  sequences 433  architectures

Clan: B_Fructosidase (CL0143)


Beta fructosidase superfamily Add an annotation

This beta fructosidase superfamily [4] is composed of glycosyl hydrolase families. The members of this clan adopt a five-bladed beta-propeller fold [2-3]. The beta-fructosidase superfamily is also known as furanosidase superfamily [4].

This clan contains 5 families and the total number of domains in the clan is 32115. The clan was built by J Mistry.

Literature references

  1. Hettwer U, Jaeckel FR, Boch J, Meyer M, Rudolph K, Ullrich MS; , Appl Environ Microbiol 1998;64:3180-3187.: Cloning, nucleotide sequence, and expression in Escherichia coli of levansucrase genes from the plant pathogens Pseudomonas syringae pv. glycinea and P. syringae pv. phaseolicola. PUBMED:9726857 EPMC:9726857
  2. Nurizzo D, Turkenburg JP, Charnock SJ, Roberts SM, Dodson EJ, McKie VA, Taylor EJ, Gilbert HJ, Davies GJ; , Nat Struct Biol 2002;9:665-668.: Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold. PUBMED:12198486 EPMC:12198486
  3. Alberto F, Bignon C, Sulzenbacher G, Henrissat B, Czjzek M; , J Biol Chem 2004;279:18903-18910.: The three-dimensional structure of invertase (beta-fructosidase) from Thermotoga maritima reveals a bimodular arrangement and an evolutionary relationship between retaining and inverting glycosidases. PUBMED:14973124 EPMC:14973124
  4. Naumoff DG; , Proteins. 2001;42:66-76.: beta-fructosidase superfamily: homology with some alpha-L-arabinases and beta-D-xylosidases. PUBMED:11093261 EPMC:11093261


This clan contains the following 5 member families:

DUF377 Glyco_hydro_32N Glyco_hydro_43 Glyco_hydro_62 Glyco_hydro_68

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Glyco_hydro_32N (PF00251) 15155 (47.2%) View
Glyco_hydro_43 (PF04616) 13723 (42.7%) View
DUF377 (PF04041) 2146 (6.7%) View
Glyco_hydro_68 (PF02435) 764 (2.4%) View
Glyco_hydro_62 (PF03664) 327 (1.0%) View
Total: 5 Total: 32115 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
DUF3357 Glyco_hydro_32N
DUF377 DUF377
Glyco_hydro_32C Glyco_hydro_32N
Glyco_hydro_32N DUF3357
Glyco_hydro_43 AbfB
Glyco_hydro_68 Glyco_hydro_68
PMEI Glyco_hydro_32N


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...