Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
7  structures 628  species 4  interactions 4016  sequences 49  architectures

Clan: Traffic (CL0147)


Trafficking protein Add an annotation

The members of this clan are involved in protein trafficking. The Sec20 family are integral membrane proteins involved in ER to Golgi transport [1] and V-SNARES are involved in membrane fusion [2].

This clan contains 3 families and the total number of domains in the clan is 4016. The clan was built by J Mistry.

Literature references

  1. Fischer von Mollard G, Stevens TH; , Mol Biol Cell 1999;10:1719-1732.: The Saccharomyces cerevisiae v-SNARE Vti1p is required for multiple membrane transport pathways to the vacuole. PUBMED:10359592 EPMC:10359592
  2. Sweet DJ, Pelham HR; , EMBO J 1993;12:2831-2840.: The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. PUBMED:8334998 EPMC:8334998


This clan contains the following 3 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
V-SNARE_C (PF12352) 2370 (59.0%) View
V-SNARE (PF05008) 915 (22.8%) View
Sec20 (PF03908) 731 (18.2%) View
Total: 3 Total: 4016 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
Synaptobrevin V-SNARE_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...