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2195  structures 180  species 11  interactions 3996  sequences 348  architectures

Clan: Viral_Gag (CL0148)


Viral Gag protein Add an annotation

This clan contains Gag proteins which are involved in viral assembly and replication [1][2].

This clan contains 3 families and the total number of domains in the clan is 3996. The clan was built by J Mistry.

Literature references

  1. Hsu HW, Schwartzberg P, Goff SP; , Virology 1985;142:211-214.: Point mutations in the P30 domain of the gag gene of Moloney murine leukemia virus. PUBMED:2414902 EPMC:2414902
  2. Wehrly K, Chesebro B; , Methods 1997;12:288-293.: p24 antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagents. PUBMED:9245608 EPMC:9245608


This clan contains the following 3 member families:

Gag_p24 Gag_p30 SCAN

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SCAN (PF02023) 3309 (82.8%) View
Gag_p30 (PF02093) 448 (11.2%) View
Gag_p24 (PF00607) 239 (6.0%) View
Total: 3 Total: 3996 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
Gag_p17 Gag_p24
Gag_p24 Gag_p17
Gag_p30 Gag_p30
MHC_I Gag_p24
MHC_II_alpha Gag_p24
MHC_II_beta Gag_p24
Pro_isomerase Gag_p24
RVP Gag_p24
V-set Gag_p24


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...