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221  structures 19174  species 13  interactions 169235  sequences 3221  architectures

Clan: CoA-acyltrans (CL0149)

Summary

CoA-dependent acyltransferase superfamily Add an annotation

All characterised families in this clan are involved in CoA-dependent acyltransferase. All families have a characteristic HXXXD motif.

This clan contains 7 families and the total number of domains in the clan is 169235. The clan was built by RD Finn.

Members

This clan contains the following 7 member families:

2-oxoacid_dh AATase Carn_acyltransf CAT Condensation Transferase WES_acyltransf

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Condensation (PF00668) 84068 (49.7%) View
2-oxoacid_dh (PF00198) 48007 (28.4%) View
WES_acyltransf (PF03007) 24645 (14.6%) View
Transferase (PF02458) 6696 (4.0%) View
Carn_acyltransf (PF00755) 2776 (1.6%) View
CAT (PF00302) 2220 (1.3%) View
AATase (PF07247) 823 (0.5%) View
Total: 7 Total: 169235 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 13 interactions for this clan. More...

Interacting families
A B
2-oxoacid_dh 2-oxoacid_dh
E1_dh
Carn_acyltransf Carn_acyltransf
CAT CAT
Condensation AMP-binding
AMP-binding_C
Condensation
HxxPF_rpt
PP-binding
Thioesterase
NO_synthase CAT
PP-binding Condensation
Transferase Transferase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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