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299  structures 944  species 23  interactions 47752  sequences 1339  architectures

Clan: C2 (CL0154)

Summary

C2 superfamily Add an annotation

This superfamily includes C2 domains and C2-like domains.

This clan contains 10 families and the total number of domains in the clan is 47752. The clan was built by A Bateman.

Literature references

  1. Ponting CP, Parker PJ; , Protein Sci 1996;5:162-166.: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin. PUBMED:8771209 EPMC:8771209
  2. Zhang D, Aravind L;, Gene. 2010;469:18-30.: Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes. PUBMED:20713135 EPMC:20713135

Members

This clan contains the following 10 member families:

Aida_C2 B9-C2 C2 C2-C2_1 CC2D2AN-C2 CEP76-C2 DOCK-C2 NT-C2 PI3K_C2 PTEN_C2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
C2 (PF00168) 40417 (84.6%) View
DOCK-C2 (PF14429) 1733 (3.6%) View
PI3K_C2 (PF00792) 1416 (3.0%) View
PTEN_C2 (PF10409) 1375 (2.9%) View
NT-C2 (PF10358) 1355 (2.8%) View
B9-C2 (PF07162) 673 (1.4%) View
C2-C2_1 (PF11618) 266 (0.6%) View
CC2D2AN-C2 (PF15625) 197 (0.4%) View
Aida_C2 (PF14186) 178 (0.4%) View
CEP76-C2 (PF15627) 142 (0.3%) View
Total: 10 Total: 47752 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 23 interactions for this clan. More...

Interacting families
A B
Aida_C2 Aida_C2
C2 C2
EF-hand_like
FGF
FYVE_2
PI-PLC-X
PI-PLC-Y
PLA2_B
S_100
DOCK-C2 DOCK-C2
DSPc PTEN_C2
EF-hand_10 C2
EF-hand_like C2
FGF C2
Ion_trans PTEN_C2
PI-PLC-X C2
PI-PLC-Y C2
PI3K_C2 PI3_PI4_kinase
PI3Ka
SH2
PTEN_C2 PTEN_C2
S_100 C2
SH2 C2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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