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16  structures 7126  species 3  interactions 8337  sequences 38  architectures

Clan: Kleisin (CL0157)


Kleisin superfamily Add an annotation

The kleisin superfamily includes ScpA, Scc1, Rec8, and Barren [1]. Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure [1].

This clan contains 2 families and the total number of domains in the clan is 8337. The clan was built by A Bateman.

Literature references

  1. Schleiffer A, Kaitna S, Maurer-Stroh S, Glotzer M, Nasmyth K, Eisenhaber F; , Mol Cell 2003;11:571-575.: Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. PUBMED:12667442 EPMC:12667442


This clan contains the following 2 member families:

Rad21_Rec8 SMC_ScpA

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SMC_ScpA (PF02616) 6352 (76.2%) View
Rad21_Rec8 (PF04824) 1985 (23.8%) View
Total: 2 Total: 8337 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
SMC_N Rad21_Rec8


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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