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1072  structures 6497  species 63  interactions 213896  sequences 9593  architectures

Clan: E-set (CL0159)


Ig-like fold superfamily (E-set) Add an annotation

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

This clan contains 63 families and the total number of domains in the clan is 213896. The clan was built by RD Finn and A Bateman.


This clan contains the following 63 member families:

A2M_N Alpha_adaptinC2 Big_1 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_4 Big_5 BiPBP_C BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_pro CARDB CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N CHU_C Coatamer_beta_C COP-gamma_platf CopC DUF1034 DUF11 DUF1973 DUF2271 DUF4165 DUF4625 DUF916 EpoR_lig-bind Filamin FixG_C FlgD_ig fn3 Fn3_assoc He_PIG HYR IFNGR1 IL6Ra-bind Integrin_alpha2 Interfer-bind Invasin_D3 MG1 Mo-co_dimer Neurexophilin NPCBM_assoc PapD_N PKD PPC Qn_am_d_aIII REJ Rib SoxZ SprB SWM_repeat T2SS-T3SS_pil_N TIG Tissue_fac Transglut_C TRAP_beta Y_Y_Y

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
fn3 (PF00041) 58087 (27.2%) View
Cadherin (PF00028) 41902 (19.6%) View
TIG (PF01833) 8379 (3.9%) View
Filamin (PF00630) 7961 (3.7%) View
PapD_N (PF00345) 7954 (3.7%) View
Big_3_4 (PF13754) 7056 (3.3%) View
DUF11 (PF01345) 6559 (3.1%) View
Big_2 (PF02368) 5992 (2.8%) View
Big_1 (PF02369) 5706 (2.7%) View
PKD (PF00801) 5437 (2.5%) View
SWM_repeat (PF13753) 4913 (2.3%) View
Y_Y_Y (PF07495) 2976 (1.4%) View
A2M_N (PF01835) 2926 (1.4%) View
Mo-co_dimer (PF03404) 2673 (1.2%) View
Cadherin_2 (PF08266) 2331 (1.1%) View
Big_3 (PF07523) 2232 (1.0%) View
He_PIG (PF05345) 2176 (1.0%) View
PPC (PF04151) 2040 (1.0%) View
FlgD_ig (PF13860) 1909 (0.9%) View
Big_4 (PF07532) 1839 (0.9%) View
HYR (PF02494) 1816 (0.8%) View
Big_3_2 (PF12245) 1694 (0.8%) View
CopC (PF04234) 1651 (0.8%) View
Rib (PF08428) 1574 (0.7%) View
Big_5 (PF13205) 1557 (0.7%) View
Integrin_alpha2 (PF08441) 1499 (0.7%) View
Alpha_adaptinC2 (PF02883) 1431 (0.7%) View
CARDB (PF07705) 1259 (0.6%) View
CHB_HEX_C (PF03174) 1239 (0.6%) View
BiPBP_C (PF06832) 1158 (0.5%) View
FixG_C (PF11614) 1156 (0.5%) View
CHU_C (PF13585) 1085 (0.5%) View
Pfam family Num. domains Alignment
MG1 (PF11974) 1084 (0.5%) View
REJ (PF02010) 1075 (0.5%) View
Transglut_C (PF00927) 1042 (0.5%) View
T2SS-T3SS_pil_N (PF13629) 1023 (0.5%) View
SprB (PF13573) 1000 (0.5%) View
DUF916 (PF06030) 922 (0.4%) View
DUF1034 (PF06280) 863 (0.4%) View
Tissue_fac (PF01108) 788 (0.4%) View
Interfer-bind (PF09294) 681 (0.3%) View
Cadherin-like (PF12733) 661 (0.3%) View
NPCBM_assoc (PF10633) 604 (0.3%) View
IL6Ra-bind (PF09240) 523 (0.2%) View
EpoR_lig-bind (PF09067) 520 (0.2%) View
Neurexophilin (PF06312) 508 (0.2%) View
SoxZ (PF08770) 444 (0.2%) View
COP-gamma_platf (PF08752) 438 (0.2%) View
Cadherin_pro (PF08758) 421 (0.2%) View
ChitinaseA_N (PF08329) 378 (0.2%) View
DUF2271 (PF10029) 357 (0.2%) View
Coatamer_beta_C (PF07718) 351 (0.2%) View
DUF1973 (PF09315) 287 (0.1%) View
Fn3_assoc (PF13287) 282 (0.1%) View
Invasin_D3 (PF09134) 269 (0.1%) View
TRAP_beta (PF05753) 254 (0.1%) View
CHB_HEX_C_1 (PF13290) 225 (0.1%) View
Big_3_3 (PF13750) 166 (0.1%) View
BsuPI (PF12690) 149 (0.1%) View
DUF4625 (PF15418) 136 (0.1%) View
IFNGR1 (PF07140) 134 (0.1%) View
DUF4165 (PF13752) 99 (0.0%) View
Qn_am_d_aIII (PF09099) 45 (0.0%) View
Total: 63 Total: 213896 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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