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31  structures 190  species 4  interactions 13225  sequences 892  architectures

Clan: CUB (CL0164)


CUB clan Add an annotation

This clan contains the CUB domain [1,2].

This clan contains 2 families and the total number of domains in the clan is 13225. The clan was built by A Bateman.

Literature references

  1. Bork P, Beckmann G; , J Mol Biol 1993;231:539-545.: The CUB domain. A widespread module in developmentally regulated proteins. PUBMED:8510165 EPMC:8510165
  2. Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ; , Nat Struct Biol 1997;4:783-788.: The crystal structures of two spermadhesins reveal the CUB domain fold. PUBMED:9334740 EPMC:9334740


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CUB (PF00431) 12961 (98.0%) View
CUB_2 (PF02408) 264 (2.0%) View
Total: 2 Total: 13225 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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