Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
41  structures 300  species 10  interactions 17897  sequences 1203  architectures

Clan: CUB (CL0164)

Summary

CUB clan Add an annotation

This clan contains the CUB domain [1,2].

This clan contains 2 families and the total number of domains in the clan is 17897. The clan was built by A Bateman.

Literature references

  1. Bork P, Beckmann G; , J Mol Biol 1993;231:539-545.: The CUB domain. A widespread module in developmentally regulated proteins. PUBMED:8510165 EPMC:8510165
  2. Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ; , Nat Struct Biol 1997;4:783-788.: The crystal structures of two spermadhesins reveal the CUB domain fold. PUBMED:9334740 EPMC:9334740

Members

This clan contains the following 2 member families:

CUB CUB_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CUB (PF00431) 17627 (98.5%) View
CUB_2 (PF02408) 270 (1.5%) View
Total: 2 Total: 17897 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 10 interactions for this clan. More...

Interacting families
A B
Cobalamin_bind CUB
CUB CUB
EGF_CA
F5_F8_type_C
FXa_inhibition
Sushi
EGF_CA CUB
F5_F8_type_C CUB
FXa_inhibition CUB
Sema CUB

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...