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45  structures 9684  species 6  interactions 38105  sequences 560  architectures

Clan: Cache (CL0165)


Cache-like domain Add an annotation

The Cache domain an extracellular domain that is thought to have a role in small-molecule recognition in a wide range of proteins, including the animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors [1].

This clan contains 6 families and the total number of domains in the clan is 38105. The clan was built by RD Finn.

Literature references

  1. Anantharaman V, Aravind L; , Trends Biochem Sci 2000;25:535-537.: Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. PUBMED:11084361 EPMC:11084361


This clan contains the following 6 member families:

Cache_1 Cache_2 Cache_3 DUF4153 DUF4173 YkuI_C

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cache_1 (PF02743) 16061 (42.1%) View
Cache_3 (PF14827) 12292 (32.3%) View
Cache_2 (PF08269) 5096 (13.4%) View
DUF4153 (PF13687) 3313 (8.7%) View
YkuI_C (PF10388) 765 (2.0%) View
DUF4173 (PF13777) 578 (1.5%) View
Total: 6 Total: 38105 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
Cache_1 Cache_1
Cache_3 Cache_3
MCP_N Cache_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...