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81  structures 12512  species 10  interactions 30857  sequences 209  architectures

Clan: Peptidase_MD (CL0170)


Peptidase MD Add an annotation

This clan is comprised of carboxypeptidases and the N-terminal domain from Sonic hedgehog proteins. The structure of the latter is similar to the peptidases, but the N-terminal domain of hedgehog has been demonstrate not to be involved in peptidase activity, but is more likely involved in signal transduction [1].

This clan contains 7 families and the total number of domains in the clan is 30857. The clan was built by RD Finn.

Literature references

  1. Fuse N, Maiti T, Wang B, Porter JA, Hall TM, Leahy DJ, Beachy PA; , Proc Natl Acad Sci U S A 1999;96:10992-10999.: Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. PUBMED:10500113 EPMC:10500113


This clan contains the following 7 member families:

HH_signal Peptidase_M15 Peptidase_M15_2 Peptidase_M15_3 Peptidase_M15_4 Peptidase_M74 VanY

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_M15 (PF01427) 8248 (26.7%) View
VanY (PF02557) 6592 (21.4%) View
Peptidase_M15_2 (PF05951) 4589 (14.9%) View
Peptidase_M74 (PF03411) 4158 (13.5%) View
Peptidase_M15_4 (PF13539) 3907 (12.7%) View
Peptidase_M15_3 (PF08291) 2875 (9.3%) View
HH_signal (PF01085) 488 (1.6%) View
Total: 7 Total: 30857 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
fn3 HH_signal
GSDH HH_signal
HH_signal fn3
Peptidase_M15 Peptidase_M15
Peptidase_M74 Peptidase_M74
PG_binding_1 Peptidase_M15_3
VanY VanY


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...