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525  structures 6336  species 25  interactions 74094  sequences 199  architectures

Clan: TetR_C (CL0174)

Summary

TetR protein, C-terminal domain-like Add an annotation

This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].

This clan contains 36 families and the total number of domains in the clan is 74094. The clan was built by M Fenech.

Literature references

  1. Rouch DA, Cram DS, DiBerardino D, Littlejohn TG, Skurray RA; , Mol Microbiol 1990;4:2051-2062.: Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. PUBMED:2089219 EPMC:2089219
  2. Grkovic S, Brown MH, Roberts NJ, Paulsen IT, Skurray RA; , J Biol Chem 1998;273:18665-18673.: QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA. PUBMED:9660841 EPMC:9660841
  3. Godsey MH, Zheleznova Heldwein EE, Brennan RG; , J Biol Chem 2002;277:40169-40172.: Structural biology of bacterial multidrug resistance gene regulators. PUBMED:12186881 EPMC:12186881
  4. Hillen W, Berens C; , Annu Rev Microbiol 1994;48:345-369.: Mechanisms underlying expression of Tn10 encoded tetracycline resistance. PUBMED:7826010 EPMC:7826010

Members

This clan contains the following 36 member families:

TetR_C_1 TetR_C_10 TetR_C_11 TetR_C_13 TetR_C_14 TetR_C_15 TetR_C_16 TetR_C_17 TetR_C_18 TetR_C_19 TetR_C_2 TetR_C_20 TetR_C_21 TetR_C_22 TetR_C_23 TetR_C_24 TetR_C_25 TetR_C_26 TetR_C_27 TetR_C_28 TetR_C_29 TetR_C_3 TetR_C_30 TetR_C_31 TetR_C_32 TetR_C_33 TetR_C_34 TetR_C_35 TetR_C_36 TetR_C_37 TetR_C_4 TetR_C_5 TetR_C_6 TetR_C_7 TetR_C_8 TetR_C_9

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TetR_C_24 (PF17932) 8098 (10.9%) View
TetR_C_33 (PF13305) 7957 (10.7%) View
TetR_C_6 (PF13977) 7477 (10.1%) View
TetR_C_1 (PF02909) 7013 (9.5%) View
TetR_C_11 (PF16859) 6479 (8.7%) View
TetR_C_7 (PF14246) 4732 (6.4%) View
TetR_C_8 (PF14278) 3807 (5.1%) View
TetR_C_14 (PF17754) 3616 (4.9%) View
TetR_C_13 (PF16925) 2903 (3.9%) View
TetR_C_16 (PF17920) 2122 (2.9%) View
TetR_C_29 (PF17938) 1849 (2.5%) View
TetR_C_31 (PF17940) 1818 (2.5%) View
TetR_C_30 (PF17939) 1607 (2.2%) View
TetR_C_3 (PF08362) 1523 (2.1%) View
TetR_C_28 (PF17937) 1306 (1.8%) View
TetR_C_15 (PF17918) 1140 (1.5%) View
TetR_C_20 (PF17925) 1075 (1.5%) View
TetR_C_22 (PF17928) 1007 (1.4%) View
TetR_C_27 (PF17935) 970 (1.3%) View
continued
Pfam family Num. domains Alignment
TetR_C_4 (PF08359) 955 (1.3%) View
TetR_C_2 (PF08361) 937 (1.3%) View
TetR_C_32 (PF09209) 772 (1.0%) View
TetR_C_23 (PF17931) 735 (1.0%) View
TetR_C_21 (PF17926) 725 (1.0%) View
TetR_C_34 (PF17929) 628 (0.8%) View
TetR_C_35 (PF18556) 595 (0.8%) View
TetR_C_10 (PF16295) 481 (0.6%) View
TetR_C_25 (PF17933) 371 (0.5%) View
TetR_C_19 (PF17924) 270 (0.4%) View
TetR_C_17 (PF17922) 217 (0.3%) View
TetR_C_5 (PF08360) 215 (0.3%) View
TetR_C_36 (PF18598) 193 (0.3%) View
TetR_C_18 (PF17923) 170 (0.2%) View
TetR_C_9 (PF14514) 136 (0.2%) View
TetR_C_26 (PF17934) 106 (0.1%) View
TetR_C_37 (PF18665) 89 (0.1%) View
Total: 36 Total: 74094 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 25 interactions for this clan. More...

Interacting families
A B
TetR_C_1 TetR_C_1
TetR_N
TetR_C_2 TetR_C_2
TetR_N
TetR_C_3 TetR_C_3
TetR_C_32 TetR_C_32
TetR_N
TetR_C_33 TetR_C_33
TetR_N
TetR_C_4 TetR_C_4
TetR_N
TetR_C_5 TetR_C_5
TetR_N
TetR_C_6 TetR_C_6
TetR_N
TetR_C_7 TetR_C_7
TetR_C_9 TetR_C_9
TetR_N TetR_C_1
TetR_C_2
TetR_C_3
TetR_C_32
TetR_C_33
TetR_C_4
TetR_C_5
TetR_C_6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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