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355  structures 2771  species 25  interactions 18308  sequences 75  architectures

Clan: TetR_C (CL0174)


TetR protein, C-terminal domain-like Add an annotation

This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].

This clan contains 13 families and the total number of domains in the clan is 18308. The clan was built by M Fenech.

Literature references

  1. Rouch DA, Cram DS, DiBerardino D, Littlejohn TG, Skurray RA; , Mol Microbiol 1990;4:2051-2062.: Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. PUBMED:2089219 EPMC:2089219
  2. Grkovic S, Brown MH, Roberts NJ, Paulsen IT, Skurray RA; , J Biol Chem 1998;273:18665-18673.: QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA. PUBMED:9660841 EPMC:9660841
  3. Godsey MH, Zheleznova Heldwein EE, Brennan RG; , J Biol Chem 2002;277:40169-40172.: Structural biology of bacterial multidrug resistance gene regulators. PUBMED:12186881 EPMC:12186881
  4. Hillen W, Berens C; , Annu Rev Microbiol 1994;48:345-369.: Mechanisms underlying expression of Tn10 encoded tetracycline resistance. PUBMED:7826010 EPMC:7826010


This clan contains the following 13 member families:

DUF1956 TetR_C TetR_C_10 TetR_C_11 TetR_C_13 TetR_C_2 TetR_C_3 TetR_C_4 TetR_C_5 TetR_C_6 TetR_C_7 TetR_C_9 WHG

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TetR_C_6 (PF13977) 3503 (19.1%) View
WHG (PF13305) 3239 (17.7%) View
TetR_C (PF02909) 3165 (17.3%) View
TetR_C_11 (PF16859) 2904 (15.9%) View
TetR_C_13 (PF16925) 1256 (6.9%) View
TetR_C_7 (PF14246) 1202 (6.6%) View
TetR_C_4 (PF08359) 956 (5.2%) View
TetR_C_3 (PF08362) 685 (3.7%) View
TetR_C_2 (PF08361) 469 (2.6%) View
DUF1956 (PF09209) 413 (2.3%) View
TetR_C_10 (PF16295) 255 (1.4%) View
TetR_C_5 (PF08360) 133 (0.7%) View
TetR_C_9 (PF14514) 128 (0.7%) View
Total: 13 Total: 18308 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 25 interactions for this clan. More...

Interacting families
DUF1956 DUF1956
TetR_C TetR_C
TetR_C_2 TetR_C_2
TetR_C_3 TetR_C_3
TetR_C_4 TetR_C_4
TetR_C_5 TetR_C_5
TetR_C_6 TetR_C_6
TetR_C_7 TetR_C_7
TetR_C_9 TetR_C_9
TetR_N DUF1956


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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