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244  structures 2464  species 12  interactions 10523  sequences 37  architectures

Clan: TetR_C (CL0174)

Summary

TetR protein, C-terminal domain-like Add an annotation

This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].

This clan contains 9 families and the total number of domains in the clan is 10523. The clan was built by M Fenech.

Literature references

  1. Rouch DA, Cram DS, DiBerardino D, Littlejohn TG, Skurray RA; , Mol Microbiol 1990;4:2051-2062.: Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins. PUBMED:2089219 EPMC:2089219
  2. Grkovic S, Brown MH, Roberts NJ, Paulsen IT, Skurray RA; , J Biol Chem 1998;273:18665-18673.: QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA. PUBMED:9660841 EPMC:9660841
  3. Godsey MH, Zheleznova Heldwein EE, Brennan RG; , J Biol Chem 2002;277:40169-40172.: Structural biology of bacterial multidrug resistance gene regulators. PUBMED:12186881 EPMC:12186881
  4. Hillen W, Berens C; , Annu Rev Microbiol 1994;48:345-369.: Mechanisms underlying expression of Tn10 encoded tetracycline resistance. PUBMED:7826010 EPMC:7826010

Members

This clan contains the following 9 member families:

DUF1956 TetR_C TetR_C_2 TetR_C_3 TetR_C_4 TetR_C_5 TetR_C_6 TetR_C_7 TetR_C_9

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TetR_C_6 (PF13977) 2956 (28.1%) View
TetR_C (PF02909) 1930 (18.3%) View
TetR_C_2 (PF08361) 1463 (13.9%) View
TetR_C_7 (PF14246) 1183 (11.2%) View
TetR_C_3 (PF08362) 1091 (10.4%) View
DUF1956 (PF09209) 836 (7.9%) View
TetR_C_4 (PF08359) 631 (6.0%) View
TetR_C_5 (PF08360) 259 (2.5%) View
TetR_C_9 (PF14514) 174 (1.7%) View
Total: 9 Total: 10523 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 12 interactions for this clan. More...

Interacting families
A B
TetR_C_4 TetR_N
TetR_C_4
TetR_C TetR_N
TetR_C
TetR_C_5 TetR_N
TetR_C_5
DUF1956 TetR_N
DUF1956
TetR_C_3 TetR_N
TetR_C_3
TetR_C_2 TetR_N
TetR_C_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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