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214  structures 19511  species 25  interactions 64268  sequences 295  architectures

Clan: PUA (CL0178)

Summary

PUA/ASCH superfamily Add an annotation

This clan consists of the RNA binding PUA domain and ASCH domain. It also contains uncharacterised protein families.

This clan contains 10 families and the total number of domains in the clan is 64268. The clan was built by A Bateman.

Literature references

  1. Ishitani R, Nureki O, Fukai S, Kijimoto T, Nameki N, Watanabe M, Kondo H, Sekine M, Okada N, Nishimura S, Yokoyama S; , J Mol Biol 2002;318:665-677.: Crystal structure of archaeosine tRNA-guanine transglycosylase. PUBMED:12054814 EPMC:12054814
  2. Iyer LM, Burroughs AM, Aravind L; , Bioinformatics. 2005; [Epub ahead of print]DR SCOP; 88697;: The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism. PUBMED:16322048 EPMC:16322048

Members

This clan contains the following 10 member families:

ASCH DUF3850 EVE LON_substr_bdg PUA PUA_2 TruB-C_2 TruB_C UPF0113 YTH

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LON_substr_bdg (PF02190) 17569 (27.3%) View
PUA (PF01472) 13962 (21.7%) View
ASCH (PF04266) 10915 (17.0%) View
EVE (PF01878) 7465 (11.6%) View
TruB-C_2 (PF09157) 6364 (9.9%) View
TruB_C (PF09142) 2295 (3.6%) View
PUA_2 (PF14306) 2286 (3.6%) View
YTH (PF04146) 1751 (2.7%) View
DUF3850 (PF12961) 1007 (1.6%) View
UPF0113 (PF03657) 654 (1.0%) View
Total: 10 Total: 64268 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 25 interactions for this clan. More...

Interacting families
A B
AA_kinase PUA
APS_kinase PUA_2
ASCH ASCH
ATP-sulfurylase PUA_2
DKCLD PUA
DUF1947 PUA
EVE EVE
LON_substr_bdg LON_substr_bdg
Methyltrans_SAM PUA
PUA AA_kinase
DKCLD
Methyltrans_SAM
PUA
SHQ1
PUA_2 APS_kinase
ATP-sulfurylase
PUA_2
SHQ1 PUA
TGT PUA
TGT_C1 PUA
TGT_C2 PUA
TruB_N PUA
TruB-C_2
TruB_C
UPF0113 UPF0113

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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