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504  structures 24239  species 41  interactions 250896  sequences 708  architectures

Clan: ATP-grasp (CL0179)

Summary

ATP-grasp superfamily Add an annotation

The ATP-grasp domain is found in a wide variety of carboxylate-amine/thiol ligases [1]. It is composed of two subdomains, with ATP being bound in the cleft between the two.

This clan contains 21 families and the total number of domains in the clan is 250896. The clan was built by A Bateman.

Literature references

  1. Galperin MY, Koonin EV; , Protein Sci 1997;6:2639-2643.: A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. PUBMED:9416615 EPMC:9416615

Members

This clan contains the following 21 member families:

ATP-grasp ATP-grasp_2 ATP-grasp_3 ATP-grasp_4 ATP-grasp_5 ATPgrasp_ST ATPgrasp_Ter ATPgrasp_TupA ATPgrasp_YheCD CP_ATPgrasp_1 CP_ATPgrasp_2 CPSase_L_D2 Dala_Dala_lig_C DUF1297 GARS_A GSH-S_ATP GSP_synth Ins134_P3_kin RimK Synapsin_C TTL

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CPSase_L_D2 (PF02786) 93493 (37.3%) View
Dala_Dala_lig_C (PF07478) 25607 (10.2%) View
ATP-grasp (PF02222) 25413 (10.1%) View
GARS_A (PF01071) 19597 (7.8%) View
ATP-grasp_4 (PF13535) 18683 (7.4%) View
ATP-grasp_2 (PF08442) 17502 (7.0%) View
GSP_synth (PF03738) 11528 (4.6%) View
ATP-grasp_5 (PF13549) 7449 (3.0%) View
RimK (PF08443) 7327 (2.9%) View
CP_ATPgrasp_2 (PF14403) 7182 (2.9%) View
GSH-S_ATP (PF02955) 6921 (2.8%) View
continued
Pfam family Num. domains Alignment
TTL (PF03133) 3670 (1.5%) View
ATPgrasp_YheCD (PF14398) 1257 (0.5%) View
ATPgrasp_ST (PF14397) 1237 (0.5%) View
ATPgrasp_TupA (PF14305) 1103 (0.4%) View
ATPgrasp_Ter (PF15632) 960 (0.4%) View
Ins134_P3_kin (PF05770) 588 (0.2%) View
ATP-grasp_3 (PF02655) 581 (0.2%) View
Synapsin_C (PF02750) 450 (0.2%) View
DUF1297 (PF06973) 291 (0.1%) View
CP_ATPgrasp_1 (PF04174) 57 (0.0%) View
Total: 21 Total: 250896 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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