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0  structures 4842  species 0  interactions 49966  sequences 126  architectures

Clan: IT (CL0182)


IT (Ion Transporter) superfamily Add an annotation

This superfamily of secondary carriers specific for cationic and anionic compounds, has been termed the ion transporter (IT) superfamily [1].

This clan contains 17 families and the total number of domains in the clan is 49966. The clan was built by A Bateman.

Literature references

  1. Prakash S, Cooper G, Singhi S, Saier MH Jr; , Biochim Biophys Acta 2003;1618:79-92.: The ion transporter superfamily. PUBMED:14643936 EPMC:14643936


This clan contains the following 17 member families:

ABG_transport ArsB CitMHS DctM DcuA_DcuB DcuC DUF1504 DUF1646 DUF401 GntP_permease Lactate_perm MatC_N Na_H_antiport_2 Na_H_antiporter Na_sulph_symp NhaB SCFA_trans

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Na_H_antiporter (PF03553) 7404 (14.8%) View
CitMHS (PF03600) 7280 (14.6%) View
DctM (PF06808) 7152 (14.3%) View
Na_sulph_symp (PF00939) 6208 (12.4%) View
GntP_permease (PF02447) 5095 (10.2%) View
DcuC (PF03606) 3902 (7.8%) View
Lactate_perm (PF02652) 3338 (6.7%) View
DcuA_DcuB (PF03605) 2671 (5.3%) View
ArsB (PF02040) 1841 (3.7%) View
ABG_transport (PF03806) 1493 (3.0%) View
Na_H_antiport_2 (PF13726) 1096 (2.2%) View
NhaB (PF06450) 838 (1.7%) View
SCFA_trans (PF02667) 740 (1.5%) View
MatC_N (PF07158) 578 (1.2%) View
DUF1504 (PF07399) 138 (0.3%) View
DUF401 (PF04165) 109 (0.2%) View
DUF1646 (PF07854) 83 (0.2%) View
Total: 17 Total: 49966 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...