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442  structures 20907  species 20  interactions 248885  sequences 10410  architectures

Clan: PAS_Fold (CL0183)

Summary

PAS domain clan Add an annotation

This clan contains PAS domains that are found in a wide variety of bacterial signaling proteins.

This clan contains 14 families and the total number of domains in the clan is 248885. The clan was built by A Bateman.

Literature references

  1. Zhulin IB, Taylor BL, Dixon R; , Trends Biochem Sci 1997;22:331-333.: PAS domain S-boxes in archaea, bacteria and sensors for oxygen and redox. PUBMED:9301332 EPMC:9301332
  2. Borgstahl GE, Williams DR, Getzoff ED; , Biochemistry 1995;34:6278-6287.: 1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore. PUBMED:7756254 EPMC:7756254
  3. Ponting CP, Aravind L; , Curr Biol 1997;7:674-677.: PAS: a multifunctional domain family comes to light. PUBMED:9382818 EPMC:9382818
  4. Hefti MH, Francoijs KJ, de Vries SC, Dixon R, Vervoort J; , Eur J Biochem 2004;271:1198-1208.: The PAS fold: a redefination of the PAS domain based upon structural prediction. PUBMED:15009198 EPMC:15009198

Members

This clan contains the following 14 member families:

CpxA_peri MEKHLA PAS PAS_10 PAS_11 PAS_12 PAS_2 PAS_3 PAS_4 PAS_5 PAS_6 PAS_7 PAS_8 PAS_9

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PAS (PF00989) 54454 (21.9%) View
PAS_9 (PF13426) 51304 (20.6%) View
PAS_3 (PF08447) 47117 (18.9%) View
PAS_4 (PF08448) 44229 (17.8%) View
PAS_8 (PF13188) 21816 (8.8%) View
PAS_6 (PF08348) 7663 (3.1%) View
PAS_7 (PF12860) 7329 (2.9%) View
PAS_10 (PF13596) 3844 (1.5%) View
CpxA_peri (PF16527) 3501 (1.4%) View
PAS_2 (PF08446) 2498 (1.0%) View
PAS_11 (PF14598) 2292 (0.9%) View
PAS_12 (PF16736) 1394 (0.6%) View
PAS_5 (PF07310) 758 (0.3%) View
MEKHLA (PF08670) 686 (0.3%) View
Total: 14 Total: 248885 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 20 interactions for this clan. More...

Interacting families
A B
GAF PAS_2
HLH PAS
PAS HATPase_c
HisKA
PAS
PAS_11
Response_reg
PAS_10 PAS_10
PAS_11 PAS
PAS_11
STAT6_C
PAS_2 GAF
PHY
PAS_3 PAS_3
PAS_4 PAS_4
PAS_8 PAS_8
PAS_9 GerE
PAS_9
Ras
PHY PAS_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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