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12  structures 5620  species 0  interactions 114318  sequences 341  architectures

Clan: DMT (CL0184)


Drug/Metabolite transporter superfamily Add an annotation

This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit [1]. Many of these families contain a characteristic glycine rich motif close to the C-terminus.

This clan contains 20 families and the total number of domains in the clan is 114318. The clan was built by A Bateman.

Literature references

  1. Jack DL, Yang NM, Saier MH Jr; , Eur J Biochem 2001;268:3620-3639.: The drug/metabolite transporter superfamily. PUBMED:11432728 EPMC:11432728
  2. Vastermark A, Almen MS, Simmen MW, Fredriksson R, Schioth HB;, BMC Evol Biol. 2011;11:123.: Functional specialization in nucleotide sugar transporters occurred through differentiation of the gene cluster EamA (DUF6) before the radiation of Viridiplantae. PUBMED:21569384 EPMC:21569384


This clan contains the following 20 member families:

Cation_efflux CRCB CRT-like DUF1632 DUF486 DUF606 DUF914 EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp RhaT Sugar_transport TPT UAA UPF0060 UPF0546 Ureide_permease Zip

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EamA (PF00892) 66028 (57.8%) View
Cation_efflux (PF01545) 12806 (11.2%) View
Multi_Drug_Res (PF00893) 6822 (6.0%) View
Zip (PF02535) 6416 (5.6%) View
CRCB (PF02537) 5746 (5.0%) View
DUF606 (PF04657) 2941 (2.6%) View
TPT (PF03151) 2906 (2.5%) View
EmrE (PF13536) 1585 (1.4%) View
UAA (PF08449) 1443 (1.3%) View
Mg_trans_NIPA (PF05653) 1396 (1.2%) View
UPF0060 (PF02694) 1396 (1.2%) View
Sugar_transport (PF06800) 1288 (1.1%) View
Nuc_sug_transp (PF04142) 1158 (1.0%) View
RhaT (PF06379) 639 (0.6%) View
DUF486 (PF04342) 583 (0.5%) View
DUF914 (PF06027) 558 (0.5%) View
UPF0546 (PF10639) 235 (0.2%) View
DUF1632 (PF07857) 180 (0.2%) View
Ureide_permease (PF07168) 165 (0.1%) View
CRT-like (PF08627) 27 (0.0%) View
Total: 20 Total: 114318 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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