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4448  structures 8912  species 0  interactions 1800257  sequences 31302  architectures

Clan: Beta_propeller (CL0186)

Summary

Beta propeller clan Add an annotation

This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled. The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.

This clan contains 112 families and the total number of domains in the clan is 1800257. The clan was built by A Bateman.

Literature references

  1. Murzin AG; , Proteins. 1992;14:191-201.: Structural principles for the propeller assembly of beta-sheets: the preference for seven-fold symmetry. PUBMED:1409568 EPMC:1409568

Members

This clan contains the following 112 member families:

ANAPC1 ANAPC4_WD40 Arylesterase Arylsulfotran_2 Arylsulfotrans B_lectin BBS2_Mid BBS2_N Beta_propel Coatomer_WDAD CPSF_A CyRPA Cytochrom_D1 DCAF17 Dpp_8_9_N DPPIV_N DPPIV_rep DUF1513 DUF1668 DUF2415 DUF346 DUF3466 DUF3616 DUF3748 DUF4221 DUF4374 DUF4394 DUF4623 DUF4784 DUF4915 DUF4933 DUF4934 DUF5046 DUF5050 DUF5122 DUF5128 DUF5711 DUF839 eIF2A FG-GAP FG-GAP_2 FG-GAP_3 Frtz Ge1_WD40 Glu_cyclase_2 Glyoxal_oxid_N Gmad1 GSDH Helveticin_J HPS3_N HPS6 Hyd_WA IKI3 Itfg2 Kelch_1 Kelch_2 Kelch_3 Kelch_4 Kelch_5 Kelch_6 Lactonase Ldl_recept_b LGFP Lgl_C LVIVD Me-amine-dh_H MgpC MRJP Nbas_N NBCH_WD40 Neisseria_PilC NHL nos_propeller nos_propeller_2 Nucleoporin_N Nup160 Nup88 P1_N PALB2_WD40 PD40 Pectate_lyase22 Peptidase_S9_N PHTB1_N Phytase-like PQQ PQQ_2 PQQ_3 RAB3GAP2_N RAG2 RCC1 RCC1_2 Reg_prop RPE65 SBBP SBP56 SdiA-regulated Sema SGL SSL_N Str_synth TcdB_toxin_midN Tectonin TolB_like VID27 Vps16_N WD40 WD40_2 WD40_3 WD40_4 WD40_like WDCP YmzC

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
WD40 (PF00400) 938410 (52.1%) View
Kelch_1 (PF01344) 114744 (6.4%) View
RCC1 (PF00415) 111186 (6.2%) View
Ldl_recept_b (PF00058) 61764 (3.4%) View
PD40 (PF07676) 56921 (3.2%) View
FG-GAP_3 (PF13517) 45403 (2.5%) View
PQQ_2 (PF13360) 35766 (2.0%) View
NHL (PF01436) 31567 (1.8%) View
FG-GAP (PF01839) 25269 (1.4%) View
Reg_prop (PF07494) 24168 (1.3%) View
ANAPC4_WD40 (PF12894) 22646 (1.3%) View
Kelch_4 (PF13418) 22327 (1.2%) View
Sema (PF01403) 18177 (1.0%) View
B_lectin (PF01453) 17751 (1.0%) View
RCC1_2 (PF13540) 16393 (0.9%) View
GSDH (PF07995) 14715 (0.8%) View
Kelch_3 (PF13415) 13912 (0.8%) View
SGL (PF08450) 13692 (0.8%) View
DPPIV_N (PF00930) 11909 (0.7%) View
Peptidase_S9_N (PF02897) 10230 (0.6%) View
Lactonase (PF10282) 10170 (0.6%) View
RPE65 (PF03055) 9447 (0.5%) View
Kelch_6 (PF13964) 9150 (0.5%) View
Kelch_5 (PF13854) 7851 (0.4%) View
CPSF_A (PF03178) 6413 (0.4%) View
eIF2A (PF08662) 6072 (0.3%) View
DUF839 (PF05787) 5912 (0.3%) View
LVIVD (PF08309) 5909 (0.3%) View
WD40_4 (PF16300) 5667 (0.3%) View
DUF5122 (PF17164) 5594 (0.3%) View
WD40_2 (PF19056) 5318 (0.3%) View
Coatomer_WDAD (PF04053) 5285 (0.3%) View
PQQ (PF01011) 5079 (0.3%) View
FG-GAP_2 (PF14312) 4875 (0.3%) View
LGFP (PF08310) 4847 (0.3%) View
Phytase-like (PF13449) 4348 (0.2%) View
NBCH_WD40 (PF20426) 4074 (0.2%) View
Str_synth (PF03088) 3933 (0.2%) View
Kelch_2 (PF07646) 3885 (0.2%) View
Nucleoporin_N (PF08801) 3235 (0.2%) View
Glyoxal_oxid_N (PF07250) 3212 (0.2%) View
SSL_N (PF20067) 3185 (0.2%) View
MRJP (PF03022) 2837 (0.2%) View
Arylsulfotran_2 (PF14269) 2782 (0.2%) View
Nup160 (PF11715) 2639 (0.1%) View
IKI3 (PF04762) 2631 (0.1%) View
Tectonin (PF19193) 2614 (0.1%) View
Hyd_WA (PF06462) 2480 (0.1%) View
Lgl_C (PF08596) 2436 (0.1%) View
PQQ_3 (PF13570) 2387 (0.1%) View
DUF1668 (PF07893) 2372 (0.1%) View
SBP56 (PF05694) 2191 (0.1%) View
Vps16_N (PF04841) 2151 (0.1%) View
DUF5128 (PF17170) 2023 (0.1%) View
Glu_cyclase_2 (PF05096) 1980 (0.1%) View
SBBP (PF06739) 1947 (0.1%) View
Cytochrom_D1 (PF02239) 1934 (0.1%) View
continued
Pfam family Num. domains Alignment
DUF5050 (PF16472) 1745 (0.1%) View
Nup88 (PF10168) 1550 (0.1%) View
Ge1_WD40 (PF16529) 1498 (0.1%) View
Gmad1 (PF10647) 1482 (0.1%) View
ANAPC1 (PF12859) 1454 (0.1%) View
Neisseria_PilC (PF05567) 1414 (0.1%) View
VID27 (PF08553) 1328 (0.1%) View
RAB3GAP2_N (PF14655) 1322 (0.1%) View
Arylesterase (PF01731) 1214 (0.1%) View
Dpp_8_9_N (PF19520) 1183 (0.1%) View
Arylsulfotrans (PF05935) 1113 (0.1%) View
PHTB1_N (PF14727) 991 (0.1%) View
DUF4394 (PF14339) 908 (0.1%) View
nos_propeller (PF18764) 893 (0.0%) View
DUF2415 (PF10313) 892 (0.0%) View
Beta_propel (PF09826) 855 (0.0%) View
Itfg2 (PF15907) 845 (0.0%) View
DUF1513 (PF07433) 797 (0.0%) View
DUF346 (PF03984) 785 (0.0%) View
BBS2_Mid (PF14783) 780 (0.0%) View
WD40_3 (PF15911) 737 (0.0%) View
BBS2_N (PF14781) 710 (0.0%) View
Frtz (PF11768) 694 (0.0%) View
SdiA-regulated (PF06977) 694 (0.0%) View
Nbas_N (PF15492) 656 (0.0%) View
TcdB_toxin_midN (PF12256) 616 (0.0%) View
DCAF17 (PF15802) 593 (0.0%) View
HPS3_N (PF14761) 582 (0.0%) View
DUF3616 (PF12275) 561 (0.0%) View
DUF5711 (PF18975) 486 (0.0%) View
WDCP (PF15390) 463 (0.0%) View
nos_propeller_2 (PF18793) 463 (0.0%) View
DUF4915 (PF16261) 452 (0.0%) View
DUF4374 (PF14298) 430 (0.0%) View
PALB2_WD40 (PF16756) 398 (0.0%) View
Pectate_lyase22 (PF14583) 374 (0.0%) View
DPPIV_rep (PF18811) 369 (0.0%) View
DUF4221 (PF13970) 316 (0.0%) View
TolB_like (PF15869) 309 (0.0%) View
DUF3466 (PF11949) 259 (0.0%) View
HPS6 (PF15702) 253 (0.0%) View
RAG2 (PF03089) 250 (0.0%) View
Me-amine-dh_H (PF06433) 220 (0.0%) View
DUF3748 (PF12566) 202 (0.0%) View
Helveticin_J (PF17312) 58 (0.0%) View
WD40_like (PF17005) 57 (0.0%) View
CyRPA (PF18638) 52 (0.0%) View
DUF4934 (PF16288) 38 (0.0%) View
DUF4623 (PF15416) 31 (0.0%) View
DUF4933 (PF16287) 20 (0.0%) View
P1_N (PF12378) 16 (0.0%) View
DUF4784 (PF16023) 16 (0.0%) View
MgpC (PF05220) 9 (0.0%) View
DUF5046 (PF16465) 5 (0.0%) View
YmzC (PF14157) 4 (0.0%) View
Total: 112 Total: 1800257
No alignment ℹ
 

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Family relationships

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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