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294  structures 8729  species 8  interactions 54873  sequences 1130  architectures

Clan: LysM (CL0187)


LysM-like domain Add an annotation

The LysM domain (Pfam:PF01476) is thought to be a general peptidoglycan-binding module. Although originally described in bacterial proteins, it has been also found in some eukaryotic sequences. It takes up a beta-alpha-alpha-beta conformation, with the beta strands forming an antiparallel beta sheet and the two alpha helices packing on one side of this sheet [1].

This clan contains 7 families and the total number of domains in the clan is 54873. The clan was built by M Fenech.

Literature references

  1. Bateman A, Bycroft M; , J Mol Biol 2000;299:1113-1119.: The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD). PUBMED:10843862 EPMC:10843862


This clan contains the following 7 member families:

gp37_C LysM OapA Phage-Gp8 Phage_gp53 Phage_tail_X T4_gp9_10

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LysM (PF01476) 52751 (96.1%) View
OapA (PF04225) 940 (1.7%) View
Phage_tail_X (PF05489) 758 (1.4%) View
Phage_gp53 (PF11246) 129 (0.2%) View
T4_gp9_10 (PF07880) 127 (0.2%) View
Phage-Gp8 (PF09215) 86 (0.2%) View
gp37_C (PF12604) 82 (0.1%) View
Total: 7 Total: 54873 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
gp37_C gp37_C
LysM LysM
OapA Peptidase_M23
Phage-Gp8 Phage-Gp8
T4_gp9_10 T4_gp9_10
YkuD LysM


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...