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107  structures 512  species 2  interactions 11687  sequences 636  architectures

Clan: CH (CL0188)


Calponin homology domain Add an annotation

The calponin homology (CH) domain is found in a variety of contexts, ranging from proteins involved in signalling pathways to cytoskeletal proteins. They seem to have diverse cellular functions, which are thought to include actin binding, involvement in the MAP kinase signalling pathway, and regulation of GEF activity in Rho family GTPase pathways. Structurally, they are organised into three layers, with two parallel alpha helices in the core being sandwiched between another two helices, one on each side [1].

This clan contains 4 families and the total number of domains in the clan is 11687. The clan was built by M Fenech.

Literature references

  1. Gimona M, Djinovic-Carugo K, Kranewitter WJ, Winder SJ; , FEBS Lett 2002;513:98-106.: Functional plasticity of CH domains. PUBMED:11911887 EPMC:11911887


This clan contains the following 4 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CH (PF00307) 10780 (92.2%) View
DUF1042 (PF06294) 395 (3.4%) View
CAMSAP_CH (PF11971) 382 (3.3%) View
CDC24 (PF06395) 130 (1.1%) View
Total: 4 Total: 11687 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
CH Actin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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