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20  structures 4568  species 1  interaction 5628  sequences 27  architectures

Clan: Endonuclease (CL0189)

Summary

Endonuclease V-like superfamily Add an annotation

This clan contains DNA repair proteins. In E. coli endonuclease V initiates DNA repair of deaminated DNA bases and has similarity to motifs required for the catalytic activity of the UvrC endonuclease [1].

This clan contains 2 families and the total number of domains in the clan is 5628. The clan was built by A Wuster.

Literature references

  1. Moe A, Ringvoll J, Nordstrand LM, Eide L, Bjoras M, Seeberg E, Rognes T, Klungland A; , Nucleic Acids Res 2003;31:3893-3900.: Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V. PUBMED:12853604 EPMC:12853604

Members

This clan contains the following 2 member families:

Endonuclease_5 UvrC_HhH_N

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UvrC_HhH_N (PF08459) 4453 (79.1%) View
Endonuclease_5 (PF04493) 1175 (20.9%) View
Total: 2 Total: 5628 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
UvrC_HhH_N UvrC_HhH_N

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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