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356  structures 4665  species 10  interactions 118601  sequences 515  architectures

Clan: MBB (CL0193)


Outer membrane beta-barrel protein superfamily Add an annotation

This clan gathers together a large set of beta barrel membrane proteins.Although these proteins have different numbers of beta strands in the barrel they have significant sequence similarity between families.

This clan contains 54 families and the total number of domains in the clan is 118601. The clan was built by A Bateman.


This clan contains the following 54 member families:

Ail_Lom Autotransporter Bac_surface_Ag Campylo_MOMP Channel_Tsx CopB DUF1302 DUF1597 DUF2320 DUF2490 DUF2860 DUF3078 DUF3138 DUF3187 DUF3308 DUF3374 DUF3575 DUF4289 DUF481 DUF560 Gcw_chp HP_OMP HP_OMP_2 KdgM LamB Legionella_OMP MipA OMP_b-brl OMP_b-brl_2 OMP_b-brl_3 OmpA_membrane Omptin OmpW Opacity OpcA OprB OprD OprF OstA_C PagL Phenol_MetA_deg Porin_1 Porin_2 Porin_4 Porin_O_P Porin_OmpG ShlB Surface_Ag_2 Toluene_X TonB_dep_Rec TraF_2 TSA Usher YfaZ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TonB_dep_Rec (PF00593) 34093 (28.7%) View
Autotransporter (PF03797) 8209 (6.9%) View
OMP_b-brl (PF13505) 7576 (6.4%) View
Usher (PF00577) 6892 (5.8%) View
Bac_surface_Ag (PF01103) 6186 (5.2%) View
Porin_1 (PF00267) 5868 (4.9%) View
Porin_4 (PF13609) 4742 (4.0%) View
Surface_Ag_2 (PF01617) 3846 (3.2%) View
Toluene_X (PF03349) 2710 (2.3%) View
HP_OMP (PF01856) 2354 (2.0%) View
OMP_b-brl_3 (PF14905) 2158 (1.8%) View
OprD (PF03573) 2107 (1.8%) View
OstA_C (PF04453) 2046 (1.7%) View
OmpW (PF03922) 1853 (1.6%) View
OMP_b-brl_2 (PF13568) 1717 (1.4%) View
MipA (PF06629) 1671 (1.4%) View
LamB (PF02264) 1601 (1.3%) View
Channel_Tsx (PF03502) 1502 (1.3%) View
Ail_Lom (PF06316) 1349 (1.1%) View
OprB (PF04966) 1348 (1.1%) View
OmpA_membrane (PF01389) 1301 (1.1%) View
ShlB (PF03865) 1287 (1.1%) View
DUF481 (PF04338) 1242 (1.0%) View
Phenol_MetA_deg (PF13557) 1206 (1.0%) View
KdgM (PF06178) 1133 (1.0%) View
Porin_O_P (PF07396) 1073 (0.9%) View
Opacity (PF02462) 799 (0.7%) View
Gcw_chp (PF09694) 705 (0.6%) View
Pfam family Num. domains Alignment
PagL (PF09411) 691 (0.6%) View
YfaZ (PF07437) 659 (0.6%) View
DUF3575 (PF12099) 605 (0.5%) View
DUF3308 (PF11751) 599 (0.5%) View
Porin_2 (PF02530) 586 (0.5%) View
DUF560 (PF04575) 575 (0.5%) View
CopB (PF05275) 554 (0.5%) View
TraF_2 (PF13729) 545 (0.5%) View
DUF2320 (PF10082) 519 (0.4%) View
Campylo_MOMP (PF05538) 514 (0.4%) View
Omptin (PF01278) 512 (0.4%) View
HP_OMP_2 (PF02521) 419 (0.4%) View
DUF1597 (PF07642) 396 (0.3%) View
TSA (PF03249) 365 (0.3%) View
DUF1302 (PF06980) 345 (0.3%) View
Porin_OmpG (PF09381) 299 (0.3%) View
DUF3078 (PF11276) 294 (0.2%) View
DUF2860 (PF11059) 262 (0.2%) View
DUF2490 (PF10677) 262 (0.2%) View
OprF (PF05736) 245 (0.2%) View
DUF4289 (PF14121) 213 (0.2%) View
Legionella_OMP (PF05150) 182 (0.2%) View
DUF3187 (PF11383) 149 (0.1%) View
DUF3374 (PF11854) 127 (0.1%) View
OpcA (PF07239) 56 (0.0%) View
DUF3138 (PF11336) 54 (0.0%) View
Total: 54 Total: 118601 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
PagL PagL
OmpW OmpW
LamB LamB
Porin_O_P Porin_O_P
TonB_dep_Rec TonB_dep_Rec
Porin_1 Porin_1


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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