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1142  structures 8009  species 19  interactions 41924  sequences 589  architectures

Clan: DSRM (CL0196)


DSRM-like clan Add an annotation

This clan contains RNA-binding domains.

This clan contains 9 families and the total number of domains in the clan is 41924. The clan was built by A Bateman.


This clan contains the following 9 member families:

Dicer_dimer Dicer_N DND1_DSRM dsRBD2 dsrm LIX1 Rad52_Rad22 Ribosomal_S5 Staufen_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
dsrm (PF00035) 23846 (56.9%) View
Ribosomal_S5 (PF00333) 10331 (24.6%) View
Dicer_dimer (PF03368) 2719 (6.5%) View
DND1_DSRM (PF14709) 1598 (3.8%) View
Rad52_Rad22 (PF04098) 1579 (3.8%) View
Staufen_C (PF16482) 1161 (2.8%) View
LIX1 (PF14954) 463 (1.1%) View
dsRBD2 (PF17842) 225 (0.5%) View
Dicer_N (PF17895) 2 (0.0%) View
Total: 9 Total: 41924 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 19 interactions for this clan. More...

Interacting families
dsrm dsrm
Rad52_Rad22 Rad52_Rad22
Ribonucleas_3_3 dsrm
Ribonuclease_3 dsrm
Ribosomal_S2 Ribosomal_S5
Ribosomal_S21e Ribosomal_S5
Ribosomal_S28e Ribosomal_S5
Ribosomal_S3_C Ribosomal_S5
Ribosomal_S4 Ribosomal_S5
Ribosomal_S5 RF-1
WD40 Ribosomal_S5


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...