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330  structures 1778  species 39  interactions 22748  sequences 404  architectures

Clan: UBC (CL0208)

Summary

Ubiquitin conjugating enzyme like superfamily Add an annotation

This superfamily includes a diverse set of proteins that bind to ubiquitin [1].

This clan contains 9 families and the total number of domains in the clan is 22748. The clan was built by A Bateman.

Literature references

  1. Andersen KM, Hofmann K, Hartmann-Petersen R; , Essays Biochem 2005;41:49-67.: Ubiquitin-binding proteins: similar, but different. PUBMED:16250897 EPMC:16250897

Members

This clan contains the following 9 member families:

Prok-E2_A Prok-E2_B Prok-E2_C Prok-E2_D Prok-E2_E RWD UEV UFC1 UQ_con

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
UQ_con (PF00179) 17227 (75.7%) View
RWD (PF05773) 3457 (15.2%) View
UEV (PF05743) 822 (3.6%) View
Prok-E2_B (PF14461) 341 (1.5%) View
Prok-E2_D (PF14460) 321 (1.4%) View
UFC1 (PF08694) 303 (1.3%) View
Prok-E2_A (PF14457) 151 (0.7%) View
Prok-E2_E (PF14462) 99 (0.4%) View
Prok-E2_C (PF14459) 27 (0.1%) View
Total: 9 Total: 22748 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 39 interactions for this clan. More...

Interacting families
A B
Cbl_N2 UQ_con
E1_UFD UQ_con
E2_bind UQ_con
HECT UQ_con
Peptidase_C65 UQ_con
Rad60-SLD UQ_con
RanGAP1_C UQ_con
SopA UQ_con
SopA_C UQ_con
ThiF UQ_con
UBA UQ_con
UBA_e1_thiolCys UQ_con
ubiquitin UQ_con
UEV Gag_p6
ubiquitin
UEV
UFC1 UFC1
UQ_con E2_bind
HECT
IBN_N
IR1-M
Peptidase_C65
Peroxin-22
Rad60-SLD
RanGAP1_C
U-box
UBA
ubiquitin
UQ_con
Xpo1
zf-A20
zf-C3HC4
zf-C3HC4_3
zf-RING_2
zf-RING_4
zf-C3HC4 UQ_con
zf-C3HC4_2 UQ_con
zf-C3HC4_3 UQ_con
zf-RING_2 UQ_con

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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