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30  structures 376  species 3  interactions 9917  sequences 353  architectures

Clan: ShK-like (CL0213)


Sea anemone toxin k like Add an annotation

Members of this clan include the Crisp domain which is involved in ryanodine receptor Ca2+ signalling, and the ShK domain which is named after the ShK channel inhibitor toxin. Both domains are cysteine rich and contain multiple disulphide bonds [1][2][3].

This clan contains 2 families and the total number of domains in the clan is 9917. The clan was built by J Mistry.

Literature references

  1. Tudor JE, Pallaghy PK, Pennington MW, Norton RS; , Nat Struct Biol. 1996;3:317-320.: Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone. PUBMED:8599755 EPMC:8599755
  2. Gibbs GM, Scanlon MJ, Swarbrick J, Curtis S, Gallant E, Dulhunty A, O'bryan MK; , J Biol Chem. 2005; [Epub ahead of print]: The crisp domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signalling. PUBMED:16339766 EPMC:16339766
  3. Castaneda O, Sotolongo V, Amor AM, Stocklin R, Anderson AJ, Harvey AL, Engstrom A, Wernstedt C, Karlsson E; , Toxicon. 1995;33:603-613.: Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. PUBMED:7660365 EPMC:7660365


This clan contains the following 2 member families:

Crisp ShK

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ShK (PF01549) 9610 (96.9%) View
Crisp (PF08562) 307 (3.1%) View
Total: 2 Total: 9917 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
CAP Crisp
Crisp CAP


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...