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16  structures 844  species 2  interactions 7208  sequences 2  architectures

Clan: Rotavirus_VP7 (CL0217)


Rotavirus VP7 protein Add an annotation

This clan consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer protein layer [1].

This clan contains 2 families and the total number of domains in the clan is 7208. The clan was built by A Bateman.

Literature references

  1. Ludert JE, Ruiz MC, Hidalgo C, Liprandi F; , J Virol 2002;76:6643-6651.: Antibodies to rotavirus outer capsid glycoprotein VP7 neutralize infectivity by inhibiting virion decapsidation. PUBMED:12050377 EPMC:12050377


This clan contains the following 2 member families:

Rotavirus_VP7 VP7

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
VP7 (PF00434) 7017 (97.4%) View
Rotavirus_VP7 (PF05868) 191 (2.6%) View
Total: 2 Total: 7208 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
VP7 VP4_haemagglut


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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