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1643  structures 854  species 151  interactions 69959  sequences 3219  architectures

Clan: EF_hand (CL0220)

Summary

EF-hand like superfamily Add an annotation

The EF hand is a calcium binding domain found in a wide variety of proteins [1].

This clan contains 22 families and the total number of domains in the clan is 69959. The clan was built by A Bateman.

Literature references

  1. Yap KL, Ames JB, Swindells MB, Ikura M; , Proteins. 1999;37:499-507.: Diversity of conformational states and changes within the EF-hand protein superfamily. PUBMED:10591109 EPMC:10591109

Members

This clan contains the following 22 member families:

Caleosin Cbl_N2 DAG_kinase_N Dockerin_1 EF-hand_1 EF-hand_10 EF-hand_11 EF-hand_2 EF-hand_3 EF-hand_4 EF-hand_5 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_9 EF-hand_like EFhand_Ca_insen IQ IQCJ-SCHIP1 p25-alpha S_100 SPARC_Ca_bdg

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EF-hand_7 (PF13499) 21287 (30.4%) View
IQ (PF00612) 17928 (25.6%) View
EF-hand_5 (PF13202) 7450 (10.6%) View
EF-hand_8 (PF13833) 6862 (9.8%) View
EF-hand_1 (PF00036) 3479 (5.0%) View
EF-hand_4 (PF12763) 3069 (4.4%) View
EF-hand_6 (PF13405) 2240 (3.2%) View
EF-hand_like (PF09279) 1220 (1.7%) View
S_100 (PF01023) 1217 (1.7%) View
EFhand_Ca_insen (PF08726) 724 (1.0%) View
SPARC_Ca_bdg (PF10591) 714 (1.0%) View
EF-hand_2 (PF09068) 681 (1.0%) View
continued
Pfam family Num. domains Alignment
EF-hand_3 (PF09069) 660 (0.9%) View
Dockerin_1 (PF00404) 544 (0.8%) View
Caleosin (PF05042) 430 (0.6%) View
p25-alpha (PF05517) 424 (0.6%) View
DAG_kinase_N (PF14513) 312 (0.4%) View
Cbl_N2 (PF02761) 275 (0.4%) View
EF-hand_11 (PF08976) 204 (0.3%) View
EF-hand_9 (PF14658) 97 (0.1%) View
EF-hand_10 (PF14788) 92 (0.1%) View
IQCJ-SCHIP1 (PF15157) 50 (0.1%) View
Total: 22 Total: 69959 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 151 interactions for this clan. More...

Interacting families
A B
BTB_2 EF-hand_8
C2 EF-hand_like
S_100
Calpain_III EF-hand_8
CaMBD EF-hand_1
EF-hand_7
EF-hand_8
CarboxypepD_reg Dockerin_1
Cbl_N Cbl_N2
Cbl_N2 Cbl_N
Cbl_N2
Cbl_N3
UQ_con
zf-C3HC4
zf-C3HC4_3
Cbl_N3 Cbl_N2
CH EF-hand_1
EF-hand_7
EFhand_Ca_insen
Cohesin Dockerin_1
DAG1 EF-hand_2
EF-hand_3
DAG_kinase_N DAG_kinase_N
Dockerin_1 Cohesin
Dockerin_1
EF-hand_1 ATP_Ca_trans_C
Ca_chan_IQ
CaATP_NAI
CaMBD
Death
EF-hand_1
EF-hand_5
EF-hand_7
EF-hand_8
EnY2
F-actin_cap_A
FGF
IQ
KCNQ_channel
MARCKS
Melittin
PI3Ka
Pik1
S_100
SAC3
Sfi1
Synuclein
EF-hand_10 C2
EF-hand_like
EF-hand_11 EF-hand_11
EF-hand_8
EF-hand_2 EF-hand_3
EF-hand_5 EF-hand_1
EF-hand_5
EF-hand_7
NAF
Pro_isomerase
Shal-type
ubiquitin
EF-hand_6 EF-hand_1
EF-hand_6
EF-hand_7
Spectrin
EF-hand_7 ATP_Ca_trans_C
Ca_chan_IQ
CaMBD
Death
EF-hand_1
EF-hand_5
EF-hand_6
EF-hand_7
EF-hand_8
FKBP_C
IQ
MARCKS
Metallophos
Myosin_head
Pro_isomerase
Shal-type
Troponin
EF-hand_8 BTB_2
Ca_chan_IQ
Calpain_inhib
CaMBD
Death
EF-hand_1
EF-hand_11
EF-hand_5
EF-hand_6
EF-hand_7
EF-hand_8
MARCKS
Shal-type
Troponin
EF-hand_like C2
EF-hand_like
PI-PLC-X
PI-PLC-Y
EFhand_Ca_insen CH
Titin_Z
F-actin_cap_A EF-hand_1
S_100
FGF S_100
FKBP_C EF-hand_7
Flavodoxin_1 EF-hand_7
FOLN SPARC_Ca_bdg
G-alpha EF-hand_like
GFP EF-hand_1
HEAT EF-hand_7
Ig_2 S_100
IL1 S_100
IQ EF-hand_1
EF-hand_6
EF-hand_7
IQ
Kazal_1 SPARC_Ca_bdg
Lectin_leg-like EF-hand_7
Metallophos EF-hand_1
EF-hand_7
Myosin_head EF-hand_1
EF-hand_6
EF-hand_7
EF-hand_8
IQ
Myosin_tail_1 S_100
NADPH_Ox EF-hand_6
Peptidase_C2 EF-hand_8
Pkinase EF-hand_1
EF-hand_5
EF-hand_6
EF-hand_7
EF-hand_8
Pro_isomerase EF-hand_7
S_100 C2
EF-hand_1
F-actin_cap_A
FGF
IL1
Myosin_tail_1
S_100
SGS
Shal-type EF-hand_5
EF-hand_7
EF-hand_8
SPARC_Ca_bdg Collagen
Spectrin EF-hand_6
EFhand_Ca_insen
Troponin EF-hand_1
EF-hand_7
EF-hand_8
WW EF-hand_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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