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2457  structures 4226  species 0  interactions 315258  sequences 9133  architectures

Clan: EF_hand (CL0220)

Summary

EF-hand like superfamily Add an annotation

The EF hand is a calcium binding domain found in a wide variety of proteins [1].

This clan contains 31 families and the total number of domains in the clan is 315258. The clan was built by A Bateman.

Literature references

  1. Yap KL, Ames JB, Swindells MB, Ikura M; , Proteins. 1999;37:499-507.: Diversity of conformational states and changes within the EF-hand protein superfamily. PUBMED:10591109 EPMC:10591109

Members

This clan contains the following 31 member families:

Ca_chan_IQ Caleosin Cbl_N2 Cullin_binding DAG_kinase_N Dockerin_1 EF-hand_1 EF-hand_10 EF-hand_11 EF-hand_12 EF-hand_13 EF-hand_14 EF-hand_2 EF-hand_3 EF-hand_4 EF-hand_5 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_9 EF-hand_like EF_assoc_2 EFhand_Ca_insen Internalin_N IQ IQCJ-SCHIP1 NADPH_Ox p25-alpha S_100 SPARC_Ca_bdg WEF-hand

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EF-hand_7 (PF13499) 91636 (29.1%) View
IQ (PF00612) 82891 (26.3%) View
EF-hand_5 (PF13202) 33086 (10.5%) View
EF-hand_8 (PF13833) 21034 (6.7%) View
EF-hand_4 (PF12763) 14263 (4.5%) View
EF-hand_1 (PF00036) 10997 (3.5%) View
EF-hand_like (PF09279) 6364 (2.0%) View
EF-hand_6 (PF13405) 6345 (2.0%) View
Ca_chan_IQ (PF08763) 4709 (1.5%) View
S_100 (PF01023) 4174 (1.3%) View
Cullin_binding (PF03556) 4102 (1.3%) View
Dockerin_1 (PF00404) 4049 (1.3%) View
EF-hand_2 (PF09068) 3996 (1.3%) View
EF-hand_3 (PF09069) 3975 (1.3%) View
EFhand_Ca_insen (PF08726) 3814 (1.2%) View
SPARC_Ca_bdg (PF10591) 3077 (1.0%) View
continued
Pfam family Num. domains Alignment
EF_assoc_2 (PF08356) 2757 (0.9%) View
EF-hand_13 (PF17958) 2036 (0.6%) View
DAG_kinase_N (PF14513) 1935 (0.6%) View
NADPH_Ox (PF08414) 1891 (0.6%) View
Caleosin (PF05042) 1885 (0.6%) View
p25-alpha (PF05517) 1499 (0.5%) View
EF-hand_14 (PF17959) 1426 (0.5%) View
Cbl_N2 (PF02761) 1235 (0.4%) View
EF-hand_11 (PF08976) 585 (0.2%) View
EF-hand_10 (PF14788) 459 (0.1%) View
EF-hand_9 (PF14658) 403 (0.1%) View
WEF-hand (PF19914) 366 (0.1%) View
IQCJ-SCHIP1 (PF15157) 220 (0.1%) View
EF-hand_12 (PF17901) 27 (0.0%) View
Internalin_N (PF12354) 22 (0.0%) View
Total: 31 Total: 315258 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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