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613  structures 3552  species 36  interactions 119430  sequences 1776  architectures

Clan: RRM (CL0221)

Summary

RRM-like clan Add an annotation

This clan contains families that are related to the RNA recognition motif domains. However, not all these families are RNA binding.

This clan contains 17 families and the total number of domains in the clan is 119430. The clan was built by A Bateman.

Members

This clan contains the following 17 member families:

BRAP2 Calcipressin DUF1866 Limkain-b1 Nup35_RRM Nup35_RRM_2 RNA_bind RRM_1 RRM_2 RRM_3 RRM_5 RRM_6 RRM_7 RRM_occluded Smg4_UPF3 Tap-RNA_bind XS

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RRM_1 (PF00076) 97323 (81.5%) View
RRM_6 (PF14259) 9959 (8.3%) View
RRM_5 (PF13893) 6100 (5.1%) View
RRM_2 (PF04059) 785 (0.7%) View
Smg4_UPF3 (PF03467) 725 (0.6%) View
RRM_7 (PF16367) 676 (0.6%) View
Calcipressin (PF04847) 650 (0.5%) View
BRAP2 (PF07576) 601 (0.5%) View
RRM_3 (PF08777) 498 (0.4%) View
XS (PF03468) 483 (0.4%) View
Nup35_RRM (PF05172) 426 (0.4%) View
Tap-RNA_bind (PF09162) 345 (0.3%) View
DUF1866 (PF08952) 257 (0.2%) View
RRM_occluded (PF16842) 223 (0.2%) View
RNA_bind (PF08675) 137 (0.1%) View
Nup35_RRM_2 (PF14605) 126 (0.1%) View
Limkain-b1 (PF11608) 116 (0.1%) View
Total: 17 Total: 119430 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 36 interactions for this clan. More...

Interacting families
A B
CAF1 RNA_bind
CBFNT RRM_1
La RRM_1
LRR_1 Tap-RNA_bind
Mago_nashi RRM_1
MIF4G_like RRM_1
MIF4G_like_2 RRM_1
NOPS RRM_1
NUDIX_2 RRM_1
RRM_6
Nup35_RRM Nup35_RRM
PHD RRM_1
Pkinase RRM_1
RBM39linker RRM_5
RRM_1 eIF3_subunit
Mago-bind
Mago_nashi
NOPS
RRM_1
RRM_6
SAP18
SF3b1
Xpo1
RRM_5 RBM39linker
RRM_5
RRM_6
SF3b1
RRM_6 NUDIX_2
RRM_1
RRM_6
SF3b1 RRM_1
Smg4_UPF3 MIF4G
Tap-RNA_bind LRR_1
Vinculin RRM_1
RRM_6
zf-RNPHF RRM_6

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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