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348  structures 7406  species 7  interactions 17898  sequences 339  architectures

Clan: MACRO (CL0223)


MACRO domain superfamily Add an annotation

This superfamily includes the Macro domain as well as the amino terminal domain from peptidase M17 proteins.

This clan contains 7 families and the total number of domains in the clan is 17898. The clan was built by A Bateman.

Literature references

  1. Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, Bycroft M, Ladurner AG; , EMBO J 2005;24:1911-1920.: The macro domain is an ADP-ribose binding module. PUBMED:15902274 EPMC:15902274


This clan contains the following 7 member families:

DUF2263 Macro Macro_2 PARG_cat Pdase_M17_N2 Peptidase_M17_N SUD-M

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Macro (PF01661) 8832 (49.3%) View
Peptidase_M17_N (PF02789) 5995 (33.5%) View
DUF2263 (PF10021) 1365 (7.6%) View
PARG_cat (PF05028) 1231 (6.9%) View
Pdase_M17_N2 (PF18295) 336 (1.9%) View
Macro_2 (PF14519) 118 (0.7%) View
SUD-M (PF11633) 21 (0.1%) View
Total: 7 Total: 17898 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
Macro Macro
PARG_cat PARG_cat
Peptidase_M17 Peptidase_M17_N
Peptidase_M17_N Peptidase_M17
Viral_protease Macro


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...