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154  structures 8398  species 3  interactions 27989  sequences 165  architectures

Clan: DHQS (CL0224)


Dehydroquinate synthase-like superfamily Add an annotation

This superfamily includes Dehydroquinate synthase and Iron containing alcohol dehydrogenase which have a similar active site organisation [1].

This clan contains 3 families and the total number of domains in the clan is 27989. The clan was built by A Bateman.

Literature references

  1. Carpenter EP, Hawkins AR, Frost JW, Brown KA; , Nature. 1998;394:299-302.: Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis. PUBMED:9685163 EPMC:9685163


This clan contains the following 3 member families:

DHQ_synthase Fe-ADH Fe-ADH_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fe-ADH (PF00465) 18101 (64.7%) View
DHQ_synthase (PF01761) 8603 (30.7%) View
Fe-ADH_2 (PF13685) 1285 (4.6%) View
Total: 3 Total: 27989 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
DHQ_synthase DHQ_synthase
Fe-ADH_2 Fe-ADH_2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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