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150  structures 8707  species 3  interactions 24567  sequences 111  architectures

Clan: MazG (CL0231)


all-alpha NTP pyrophosphohydrolase superfamily Add an annotation

This superfamily includes MazG, HisE and dimeric dUTPases (Not yet in Pfam) [1].

This clan contains 6 families and the total number of domains in the clan is 24567. The clan was built by A Bateman.

Literature references

  1. Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY; , J Mol Biol. 2005;347:243-255.: Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. PUBMED:15740738 EPMC:15740738


This clan contains the following 6 member families:

DHR10 DUF550 dUTPase_2 MazG MazG-like PRA-PH

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MazG (PF03819) 12428 (50.6%) View
PRA-PH (PF01503) 8098 (33.0%) View
MazG-like (PF12643) 2474 (10.1%) View
dUTPase_2 (PF08761) 968 (3.9%) View
DHR10 (PF18595) 523 (2.1%) View
DUF550 (PF04447) 76 (0.3%) View
Total: 6 Total: 24567 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
dUTPase_2 dUTPase_2
MazG MazG


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...