Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
722  structures 20010  species 16  interactions 164380  sequences 858  architectures

Clan: HD_PDEase (CL0237)

Summary

HD/PDEase superfamily Add an annotation

This clan includes a range of phosphohydrolase enzymes with a common helical fold.

This clan contains 10 families and the total number of domains in the clan is 164380. The clan was built by A Bateman.

Members

This clan contains the following 10 member families:

HD HD_2 HD_3 HD_4 HD_5 HDOD MIOX PDEase_I TraI_2 tRNA_NucTran2_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HD (PF01966) 94574 (57.5%) View
HD_4 (PF13328) 27914 (17.0%) View
HDOD (PF08668) 8086 (4.9%) View
tRNA_NucTran2_2 (PF13735) 7787 (4.7%) View
HD_3 (PF13023) 7373 (4.5%) View
HD_5 (PF13487) 7067 (4.3%) View
HD_2 (PF12917) 4904 (3.0%) View
PDEase_I (PF00233) 4136 (2.5%) View
TraI_2 (PF07514) 1813 (1.1%) View
MIOX (PF05153) 726 (0.4%) View
Total: 10 Total: 164380 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 16 interactions for this clan. More...

Interacting families
A B
GAF PDEase_I
HD HD
HD_assoc
RelA_SpoT
HD_2 HD_2
HD_3 HD_3
HD_4 HD_4
HD_5 HD_5
HDOD HDOD
MIOX MIOX
PDEase_I PDE6_gamma
PDEase_I
PolyA_pol tRNA_NucTran2_2
PolyA_pol_RNAbd tRNA_NucTran2_2
tRNA_edit HDOD
tRNA_NucTran2_2 PolyA_pol

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...