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1199  structures 412  species 11  interactions 1851  sequences 7  architectures

Clan: Insulin (CL0239)

Summary

Insulin-like superfamily Add an annotation

This superfamily includes the insulin like hormones.

This clan contains 2 families and the total number of domains in the clan is 1851. The clan was built by A Bateman.

Members

This clan contains the following 2 member families:

Ins_beta Insulin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Insulin (PF00049) 1725 (93.2%) View
Ins_beta (PF03488) 126 (6.8%) View
Total: 2 Total: 1851 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
CIMR Insulin
fn2 Insulin
IGFBP Insulin
Insulin IGFBP
Insulin
Recep_L_domain
Thyroglobulin_1
Peptidase_M16 Insulin
Peptidase_M16_C Insulin
Recep_L_domain Insulin
Thyroglobulin_1 Insulin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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