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63  structures 20190  species 3  interactions 190837  sequences 339  architectures

Clan: ABC_membrane (CL0241)


ABC transporter membrane domain clan Add an annotation

This clan includes families that are the membrane components of ABC transporter complexes. In general these regions are composed of six transmembrane helices [1].

This clan contains 4 families and the total number of domains in the clan is 190837. The clan was built by A Bateman.

Literature references

  1. Chang G; , J Mol Biol. 2003;330:419-430.: Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation. PUBMED:12823979 EPMC:12823979


This clan contains the following 4 member families:

ABC_membrane ABC_membrane_2 ABC_membrane_3 SbmA_BacA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ABC_membrane (PF00664) 178090 (93.3%) View
ABC_membrane_2 (PF06472) 7488 (3.9%) View
SbmA_BacA (PF05992) 4672 (2.4%) View
ABC_membrane_3 (PF13748) 587 (0.3%) View
Total: 4 Total: 190837 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
ABC_membrane ABC_membrane
ABC_tran ABC_membrane


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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