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279  structures 5233  species 11  interactions 53370  sequences 161  architectures

Clan: ISOCOT_Fold (CL0246)

Summary

Isomerase,CoA transferase & Translation initiation factor Superfamily Add an annotation

This superfamily contains a variety of enzymes and non-enzymatic ligand binding domains.

This clan contains 11 families and the total number of domains in the clan is 53370. The clan was built by A Bateman and V Anantharaman.

Literature references

  1. Anantharaman V, Aravind L;, J Mol Biol. 2006;356:823-842.: Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. PUBMED:16376935 EPMC:16376935

Members

This clan contains the following 11 member families:

5-FTHF_cyc-lig AcetylCoA_hyd_C AcetylCoA_hydro CitF CoA_trans DeoRC DUF162 Glucosamine_iso IF-2B Rib_5-P_isom_A Sugar-bind

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DeoRC (PF00455) 14356 (26.9%) View
CoA_trans (PF01144) 6881 (12.9%) View
Glucosamine_iso (PF01182) 6449 (12.1%) View
5-FTHF_cyc-lig (PF01812) 4810 (9.0%) View
DUF162 (PF02589) 4142 (7.8%) View
Sugar-bind (PF04198) 3935 (7.4%) View
Rib_5-P_isom_A (PF06026) 3557 (6.7%) View
IF-2B (PF01008) 3047 (5.7%) View
AcetylCoA_hydro (PF02550) 2652 (5.0%) View
AcetylCoA_hyd_C (PF13336) 2410 (4.5%) View
CitF (PF04223) 1131 (2.1%) View
Total: 11 Total: 53370 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
CitF CitF
Glucosamine_iso Glucosamine_iso
5-FTHF_cyc-lig 5-FTHF_cyc-lig
CoA_trans CoA_trans
DUF162 DUF162
DeoRC Rib_5-P_isom_A
AcetylCoA_hydro AcetylCoA_hydro
Rib_5-P_isom_A DeoRC
Rib_5-P_isom_A
IF-2B IF-2B
Sugar-bind Sugar-bind

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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