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32  structures 6614  species 4  interactions 7343  sequences 34  architectures

Clan: GAD (CL0250)


GAD domain superfamily Add an annotation

This domain is found as an insert within aspartyl-tRNA synthetase as well as GatB proteins.

This clan contains 3 families and the total number of domains in the clan is 7343. The clan was built by A Bateman.

Literature references

  1. Wolf YI, Aravind L, Grishin NV, Koonin EV; , Genome Res 1999;9:689-710.: Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. PUBMED:10447505 EPMC:10447505


This clan contains the following 3 member families:

DUF4443 GAD GAD-like

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GAD (PF02938) 7081 (96.4%) View
GAD-like (PF08887) 230 (3.1%) View
DUF4443 (PF14544) 32 (0.4%) View
Total: 3 Total: 7343 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
tRNA-synt_2 GAD


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...