Summary
GAD domain superfamily
This domain is found as an insert within aspartyl-tRNA synthetase as well as GatB proteins.
This clan contains 3 families and the total number of domains in the clan is 7343. The clan was built by A Bateman.
Literature references
- Wolf YI, Aravind L, Grishin NV, Koonin EV; , Genome Res 1999;9:689-710.: Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. PUBMED:10447505 EPMC:10447505
Members
This clan contains the following 3 member families:
DUF4443 GAD GAD-likeExternal database links
SCOP: | 55261 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
GAD (PF02938) | 7081 (96.4%) | View |
GAD-like (PF08887) | 230 (3.1%) | View |
DUF4443 (PF14544) | 32 (0.4%) | View |
Total: 3 | Total: 7343 | Clan alignment |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Interactions
There are 4 interactions for this clan. More...
Interacting families | |
---|---|
A | B |
GAD | GAD |
tRNA-synt_2 | |
GatB_N | GAD |
tRNA-synt_2 | GAD |
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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